Cytogenetic monitoring in coke oven workers

Kalina, I; Brezáni, P; Gajdošová, Dagmar; Binková, Blanka; Salagovic, J; Habalová, Viera; Mračková, Gabriela; Dobiáš, L.; Šrám, Radìm J.

doi:10.1016/s1383-5718(98)00089-8

Cited by 45 publications

(29 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relationships to exposure were observed with PAHs (7,13,18,19), acrylonitrile with dimethyl formamide (35), styrene (36), BD (37), epichlorohydrin (40), and Cr and Ni (48). No effects were found with exposure to VOCs (23), hydrocarbons (25), or benzene (22,28).…”

Section: Discussionmentioning

confidence: 97%

“…They were determined in 13 studies. In 11 studies effects of exposure to PAHs in coke ovens (7), hydrocarbons (25), benzene (31,32), acrylonitrile together with dimethyl formamide (35), BD (37,39), pesticides in farmers (41), fluorides (47), cytostatics (49), and cosmic radiation (54) were observed. Only in two studies, greenhouse workers exposed to pesticides (44) and crews exposed to cosmic radiation (55), were no effects of exposure found.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic polymorphisms of CYP2E1, GSTM1, and PONaffected the frequency of CAs using a challenge assay (41). No effects of GSTM1, NAT2, and/or CYPJAJ were observed with exposure to PAHs in coke ovens (6)(7)(8)(9)(10)(11)(12)(13)(14) and oil well fires (20), to organic solvents (34) or to pesticides (44,56).…”

Section: Discussionmentioning

confidence: 99%

“…(14). Coke oven and foundry workers certainly represent a group of subjects highly exposed to PAHs (6)(7)(8)(9)(10)(11)(12)(13). Using biomarkers of exposure such as DNA adducts (6,13) and 1-OHpyrene (9), significantly higher levels of PAHs were seen in these workers compared with levels in control groups.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Molecular Epidemiology Studies on Occupational and Environmental Exposure to Mutagens and Carcinogens, 1997-1999

Srám¹,

Binková²

2000

Environmental Health Perspectives

View full text Add to dashboard Cite

Molecular epidemiology is a new and evolving area of research, combining laboratory measurement of internal dose, biologically effective dose, biologic effects, and influence of individual susceptibility with epidemiologic methodologies. Biomarkers evaluated were selected according to basic scheme: biomarkers of exposure-metabolites in urine, DNA adducts, protein adducts, and Comet assay parameters; biomarkers of effect-chromosomal aberrations, sister chromatid exchanges, micronuclei, mutations in the hypoxanthine-guanine phosphoribosyltransferase gene, and the activation of oncogenes coding for p53 or p21 proteins as measured on protein levels; biomarkers of susceptibility-genetic polymorphisms of genes CYP1A1, GSTM1, GSTT1, NAT2. DNA adducts measured by 32P-postlabeling are the biomarker of choice for the evaluation of exposure to polycyclic aromatic hydrocarbons. Protein adducts are useful as a biomarker for exposure to tobacco smoke (4-aminobiphenyl) or to smaller molecules such as acrylonitrile or 1,3-butadiene. Of the biomarkers of effect, the most common are cytogenetic end points. Epidemiologic studies support the use of chromosomal breakage as a relevant biomarker of cancer risk. The use of the Comet assay and methods analyzing oxidative DNA damage needs reliable validation for human biomonitoring. Until now there have not been sufficient data to interpret the relationship between genotypes, biomarkers of exposure, and biomarkers of effect for assessing the risk of human exposure to mutagens and carcinogens. Key words: air pollution, benzene, biomarkers, coke oven, genotypes, occupational exposure, PAHs, pesticides, tobacco smoke. -Envwron Health Perspect 1 08(suppl 1):57-70 (2000). http.//ehpnetl. niehs. nih.gov/docs/2000/suppl-1/57-70sram/abstract. html A new and evolving area of research termed molecular epidemiology attempts to merge sophisticated and highly sensitive laboratory methods (many of them developed during the recent revolution in molecular biology) with analytical epidemiologic methods. Molecular epidemiology bridges basic research in molecular biology and studies of human cancer causation by combining laboratory measurement of internal dose, biologically effective dose, biologic effects, and the influence of individual susceptibility with epidemiologic methodologies (1). The most common view is that the approach represents a natural convergence of molecular biology and epidemiology (2).The number of biomarkers available for evaluating genetic and cancer risk in humans is quite large. Their utility-for human biomonitoring is suggested by the well-known paradigm of environmentally induced cancer, which represents end points for assessing the entire spectrum of human-genotoxicant interactions (3). These biomarkers begin with exposure and include absorption, metabolism, distribution, critical target interaction (i.e., DNA damage and repair), genetic changes, and finally, disease, which is the province of traditional epidemiology. The development of biomarkers has given rise to the field of ...

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Molecular Epidemiology Studies on Occupational and Environmental Exposure to Mutagens and Carcinogens, 1997-1999

Srám¹,

Binková²

2000

Environmental Health Perspectives

View full text Add to dashboard Cite

show abstract

“…All the cytogenetic markers and sister chromatid exchange were significantly increased in the exposed compared with the control group even when smoking status was taken into account. No effects of GSTM1 or N-acetyltransferase (NAT2) genotypes (individually or in combination) on the cytogenetic markers were observed (Kalina et al, 1998).…”

Section: (E) Coke Ovensmentioning

confidence: 99%

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Hellou¹,

Beach²,

Leonard³

et al. 2012

Polycyclic Aromatic Compounds

View full text Add to dashboard Cite

initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations. The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved.The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications -whether for sale or for noncommercial distribution -should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: permissions@who.int).The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The IARC Monographs Working Group alone is responsible for the views expressed in this publication. IARC Library Cataloguing in Publication Data NOTE TO THE READERThe term 'carcinogenic risk' in the IARC Monographs series is taken to mean that an agent is capable of causing cancer under some circumstances. The Monographs evaluate cancer hazards, despite the historical presence of the word 'risks' in the title.Inclusion of an agent in the Monographs does not imply that it is a carcinogen, only that the published data have been examined. Equally, the fact that an agent has not yet been evaluated in a Monograph does not mean that it is not carcinogenic.The evaluations of carcinogenic risk are made by international working groups of independent scientists and are qualitative in nature. No recommendation is given for regulation or legislation.Anyone who is aware of published data that may alter the evaluation of the carcinogenic risk of an agent to humans is encouraged to make this information available to the Section of IARC Monographs, International Agency for...

show abstract

Toxic and Genotoxic Effects of Mixtures of Polycyclic Aromatic Hydrocarbons

Donnelly

Naufal

2010

Principles and Practice of Mixtures Toxicology

View full text Add to dashboard Cite

Cytogenetic monitoring in coke oven workers

Cited by 45 publications

References 30 publications

Molecular Epidemiology Studies on Occupational and Environmental Exposure to Mutagens and Carcinogens, 1997-1999

Molecular Epidemiology Studies on Occupational and Environmental Exposure to Mutagens and Carcinogens, 1997-1999

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Toxic and Genotoxic Effects of Mixtures of Polycyclic Aromatic Hydrocarbons

Contact Info

Product

Resources

About