Cytogenetic studies of 35 meningiomas and their clinical significance

Poulsgård, L; Rønne, Mogens

doi:10.1016/0165-4608(89)90350-6

Cited by 3 publications

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“…Over the last few decades, an increasing amount of information has accumulated on genetic abnormalities in meningioma patients (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Most of this information has been obtained through conventional cytogenetic studies (3-6,10 -12).…”

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confidence: 99%

Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome‐specific probes

et al. 2002

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Objective: Although information on the cytogenetic characteristics of meningioma tumors has accumulated progressively over the past few decades, information on the genetic heterogeneity of meningiomas is still scanty. The aim of the present study was to analyze by interphase fluorescence in situ hybridization (FISH) the incidence of numerical abnormalities for chromosomes 1, 9, 10, 11, 14, 15, 17, 22, X, and Y in a group of 70 consecutive meningioma tumors. Another goal was to establish the potential associations among the altered chromosomes, as a way to assess both intertumoral and intratumoral heterogeneity. Methods: For the purpose of the study, 70 patients diagnosed with meningioma were analyzed. Interphase FISH for the detection of numerical abnormalities for chromosomes 1, 9, 10, 11, 14, 15, 17, 22, X, and Y was applied to fresh tumor samples from each of the patients studied. Results: The overall incidence of numerical abnormalities was 76%. Chromosome Y in males and chromosome 22 in the whole series were the most common abnormalities (46% and 61%, respectively). Despite the finding that monosomy of chromosome 22/22q -deletions are the most frequent individual abnormality (53%), we have observed that chromosome gains are significantly more common than chromosome losses (60% versus 40%). Chromosome gains corresponded to abnormalities of chromosomes 1 (27%), 9 (25%), 10 (23%), 11 (22%), 14 (33%), 15 (22%), 17 (23%), and X in females (35%) and males (23%) whereas chromosome losses apart from chromosome 22 frequently involved chromosomes 14 (19%), X in males (23%), and Y in males (32%). Although an association was found among most gained chromosomes on one side and chromosome losses on the other side, different association patterns were observed. Furthermore, in the latter group, monosomy 22/22q -was associated with monosomy X in females and monosomy 14/14q -was associated with nulisomy Y in males. In addition, chromosome losses usually involved a large proportion of the tumor cells whereas chromosome gains were restricted to small tumor cell clones, including tetraploid cells. Conclusions: Our results show that meningiomas are genetically heterogeneous tumors that display different patterns of numerical chromosome changes, as assessed by interphase FISH. Cytometry (Clin. Cytometry) 50:153-159, 2002.

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Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome‐specific probes

et al. 2002

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“…45 The most frequent chromosomal abnormality is chromosome 22 monosomy, which occurs in 70-85% of all meningiomas. 47 Transitional and fibrous meningiomas exhibit the above abnormalities more frequently than the meningothelial variant. 47 Transitional and fibrous meningiomas exhibit the above abnormalities more frequently than the meningothelial variant.…”

Section: Cytogeneticsmentioning

confidence: 99%

Atypical and Malignant Meningiomas

Alexiou¹,

Kaba

Kyritsis³

2012

Textbook of Uncommon Cancer

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“…There have been a considerable number of cytogenetic studies of meningioma [4][5][6][7][8]. These have demonstrated the occurrence in 60% of these tumours of monosomy or partial deletion of chromosome 22.…”

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confidence: 99%

The contribution of cytogenetics to the histogenesis of meningeal hemangiopericytoma

Zattara-Cannoni

North

Gambarelli³

et al. 1996

J Neuro-Oncol

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Some controversy has existed regarding the nosology of meningeal hemangiopericytoma. In the WHO's classification of 1979 these tumours were included as a subgroup of meningiomas, but for some authors, they should not be classified as meningiomas. Cytogenetic studies on meningioma demonstrate monosomy or partial deletion of chromosome 22 in 60% of these tumors. There have been few cytogenetic studies about meningeal hemangiopericytoma. We present here the results of cytogenetic studies and fluorescence in situ hybridization in six cases of meningeal hemangiopericytoma. In these tumours we have never found monosomy 22, but all six cases were hyperdiploid. These cytogenetic data might provide additional evidence to differenciate the meningeal hemangiopericytoma from the meningioma.

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Cytogenetic studies of 35 meningiomas and their clinical significance

Cited by 3 publications

References 0 publications

Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome‐specific probes

Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome‐specific probes

Atypical and Malignant Meningiomas

The contribution of cytogenetics to the histogenesis of meningeal hemangiopericytoma

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