ABSTRACT. Serum proteins and RBC enzymes were surveyed in 16 species (183 animals) of African guenons (tribe Cercopithecini) in order to determine their genetic polymorphism and to establish dendrograms on the basis of their allele frequencies. The molecular data obtained were compared with those of mangabeys (16 animals tested) and discussed in the light of our results in Papio and Macaca. The species surveyed were Cercopithecus neglectus, C. hamlyni, C. l'hoesti (C. l'h. l'hoesti, C. l'h. preussi, and C. l'h. solatus), C. nictitans, C. mitis (C. m. kolbi, C. m. albotorquatus, C. m. stuhlmanni, and C. m
. albogularis), C. cephus, C. ascanius, C. erythrotis, C. petaurista, C. mona, C. pogonias, C. wolff, and C. aethiops, Miopithecus talapoin, Allenopithecus nigroviridis and Erythrocebus patas, Lophocebus albigena, and Cercocebus torquatus.Eleven loci (ten systems) were studied in red blood cell enzymes and the Gc, Gin, Km, and Bm systems in DBP and immunoglobulin serum proteins. Most of the loci were polymorphic. Similar and different polymorphisms occur in closely related species or subspecies, particularly in Cercopithecus. Guenons have phenotypes clearly distinct from mangabeys.