Cytogenetic study of pesticides in agricultural work

Högstedt, Benkt; Kolnig, A.-M.; Mitelman, Felix; Skerfving, Staffan

doi:10.1111/j.1601-5223.1980.tb01692.x

Cited by 20 publications

(2 citation statements)

References 5 publications

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“…Kourakis et al [1996] observed a clastogenic effect on human somatic cells. However, positive findings have not been substantiated in other investigations [Rabello et al, 1975;Hogstedt et al, 1980;De Cassia et al, 1982]. Several biomonitoring studies have shown an increase in the micronuclei frequency in workers with occupational exposure to pesticides [Bolognesi et al, 1993[Bolognesi et al, , 2004Joksic et al, 1997] while negative results have been reported in others [Pastor et al, 2003].…”

Section: Discussionmentioning

confidence: 87%

Investigation of the genotoxic effect of pesticides on greenhouse workers' lymphocytes

Piperakis¹,

Kontogianni²,

Karanastasi³

et al. 2008

Environ and Mol Mutagen

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In the present study, the genotoxic effects of commonly applied pesticides were evaluated using the alkaline comet assay (pH > 13). The amount of DNA damage (% DNA in tail) in peripheral lymphocytes of 49 male agricultural workers from Southern Poland were measured and compared to 50 men from the same area who had no previous occupational exposure to pesticides. No statistically significant differences in basal DNA damage were found between the study groups. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide (100 and 150 microM) or gamma-irradiation (2.5 or 4.2 Gy) led to a similar degree of additional DNA damage and subsequent repair (for 2 hr) for all studied populations. In conclusion, our results indicate that the greenhouse workers who participated in this study had no detectable increased DNA damage or alteration in their cellular response to DNA damage in comparison to our control population.

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Section: Discussionmentioning

confidence: 87%

Investigation of the genotoxic effect of pesticides on greenhouse workers' lymphocytes

Piperakis¹,

Kontogianni²,

Karanastasi³

et al. 2008

Environ and Mol Mutagen

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“…Only in a few of these tests was 2,4,5-T (not included in the present study) weakly mutagenic (see Grant 1979 for references). No conclusive chromosomal alterations have been found in the lymphocytes of persons exposed to 2,4,5-T and many other pesticides (Hogstedt et al 1980;Crossen et al 1978;Yoder et al 1973). When 2,4-D and MCPA were tested in different mutagenicity tests, only weakly positive or negative data were obtained (see Seiler 1978 for references).…”

Section: In Test Inal Pn Potmentioning

confidence: 99%

Effects of Phenoxyherbicides and Glyphosate on the Hepatic and Intestinal Biotransformation Activities in the Rat

Hietanen

Linnainmaa

Vainio

1983

Acta Pharmacologica et Toxicologica

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The effects of phenoxyacid herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and MCPA (4-chloro-2methylphenoxyacetic acid), clofibrate, and glyphosate on hepatic and intestinal drug metabolizing enzyme activities were studied in rats intragastrically exposed for 2 weeks. The hepatic ethoxycoumarin 0-deethylase activity increased about 2-fold with MCPA. Both 2,4-D and MCPA increased the hepatic epoxide hydrolase activity and decreased the hepatic glutathione S-transferase activity. MCPA also increased the intestinal activities of ethoxycoumarin 0-deethylase and epoxide hydrolase. Glyphosate decreased the hepatic level of cytochrome P-450 and monooxygenase activities and the intestinal activity of aryl hydrocarbon hydroxylase. Clofibrate decreased the hepatic activities of UDPglucuronosyltransferase with p-nitrophenol or methylumbelliferone as the substrate. Also 2,4-D decreased the hepatic activity of UDPglucuronosyltransferase with pnitrophenol as the substrate. MCPA decreased the intestinal activities of UDPglucuronosyltransferase with either p-nitrophenol or methylumbelliferone as the substrate. The results indicate that phenoxyacetic acids, especially MCPA, may have potent effects on the metabolism of xenobiotics. Glyphosate, not chemically related to phenoxyacids, seems to inhibit monooxygenases. Whether these changes are related to the toxicity of these xenobiotics remains to be clarified in further experiments.

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Genotoxicity studies on the phenoxyacetates 2,4-D and 4-CPA in theDrosophilawing spot test

Kaya

Yanıkoğlu

Marcos

1999

Teratog. Carcinog. Mutagen.

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Cytogenetic study of pesticides in agricultural work

Cited by 20 publications

References 5 publications

Investigation of the genotoxic effect of pesticides on greenhouse workers' lymphocytes

Investigation of the genotoxic effect of pesticides on greenhouse workers' lymphocytes

Effects of Phenoxyherbicides and Glyphosate on the Hepatic and Intestinal Biotransformation Activities in the Rat

Genotoxicity studies on the phenoxyacetates 2,4-D and 4-CPA in theDrosophilawing spot test

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