Cytogenetic study on individuals occupationally exposed to DDT

Rabello, Marco

doi:10.1016/0165-1218(75)90147-0

Cited by 6 publications

(5 citation statements)

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“…Backer (17) noted a statistically significant elevation in the percentage of cells with micronuclei among dogs in Aberdeen compared to those in neighboring communities. Other investigators have found some organochlorines including DDT to be mutagenic (49)(50)(51).…”

Section: Organochlorines and Immune Markersmentioning

confidence: 98%

Effects on the Immune System Associated with Living near a Pesticide Dump Site

Vine¹,

Stein²,

Weigle³

et al. 2000

Environmental Health Perspectives

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Section: Organochlorines and Immune Markersmentioning

confidence: 98%

Effects on the Immune System Associated with Living near a Pesticide Dump Site

Vine¹,

Stein²,

Weigle³

et al. 2000

Environmental Health Perspectives

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“…Many reports have shown the use of cytogenetic biomonitoring in populations exposed to pesticides [4][5][6][7][8][9][10][11][12][13][14][15]. Factors such as age, sex, lifestyle, smoking habits, alcohol consumption, and history of recent illnesses can influence the frequency of genotoxic effects [16].…”

Section: Introductionmentioning

confidence: 99%

Chromosomal aberrations analysis in a Brazilian population exposed to pesticides

Antonucci

Cólus

2000

Teratog. Carcinog. Mutagen.

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In spite of being harmful, pesticides are widely used in Brazil. Their genotoxic effects might be studied through population monitoring by means of the analysis of chromosomal aberrations in occupationally exposed individuals. The aim of this study was to evaluate the chromosomal aberration frequencies in temporary cultures of lymphocytes from periferic blood of 23 workers professionally exposed to a mixture of pesticides. The workers were employed by the Agronomic Institute of Parana (Brazil) and used all of the prevention measures provided. A detailed history of pesticide use, as well as personal data, smoking habits, and history of recent illnesses and medical treatment were collected through a standardized questionnaire administered to each subject. Nonexposed subjects, matched for age, sex, and smoking habits, served as the negative control. A total of 100 cells were analyzed from each individual. A significant increase in chromosomal aberration frequencies was observed in exposed individuals when compared to the control group. Some individual characteristics such as age, sex, time of exposure to the pesticides, and smoking habits showed no correlation with chromosomal aberrations. Therefore, the positive results may be considered true effects of pesticides on human somatic cells.

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“…Environmental toxicology and chemistry in Latin America is a relatively young discipline. Whereas the first international publications in the United States, for example, can be tracked to the 1920s and 1930s 1–4, in Latin America the earliest international publications appeared in the 1970s 5–14 (Fig. 1).…”

Section: How Has Environmental Research Developed In Latin America?mentioning

confidence: 99%