Cytogenetics Findings of Patients With Acute Lymphoblastic Leukemia in West Indian Region.

Gadhia, Pankaj

doi:10.21474/ijar01/6473

Cited by 4 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, Ph + was detected in 30% (36/120) of B-ALL cases. is finding is nearly similar to that reported by Gadhia et al [19] (33.3%) and higher than that reported by Obadiah et al [16] (17.5% (18/103)).…”

Section: Discussionsupporting

confidence: 89%

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients

Aref

Agdar

Khaled

et al. 2020

Advances in Hematology

View full text Add to dashboard Cite

This study aimed to determine the clinical impact of CD25+/CD123+ coexpression in adult B-cell acute lymphoblastic leukemia (B-ALL) cases. One hundred and twenty newly diagnosed B-ALL patients (≤60 years old) were included in this study. CD123 and CD25 expression on leukemic blast cells were assessed using flow cytometry. CD25+/CD123+ coexpression was detected in 40/120 B-ALL patients (33.3%). All B-ALL patients showed CD25+/CD123+ coexpression had lower induction of remission response and shorter overall survival as compared to B-ALL cases lacking coexpression. In conclusion, CD25+/CD123+ positive coexpression is a reliable flow cytometry marker for prediction of the outcome of adult B-ALL patients and could be used as a novel parameter for risk stratification of adult B-ALL cases.

show abstract

Section: Discussionsupporting

confidence: 89%

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients

Aref

Agdar

Khaled

et al. 2020

Advances in Hematology

View full text Add to dashboard Cite

show abstract

“…The cytogenetic abnormalities obtained from karyotyping indicate a better outcome for critical diagnosis and prognostic information [10]. The success rate of this technique depends clearly on the sample condition, sample processing methods, type of disease, and presence of metaphase spreads [11].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the cytogenetic profile in patients with acute leukaemia

Kulkarni¹,

Shetty²,

Hl³

et al. 2023

pjp

View full text Add to dashboard Cite

Acute leukaemia (AL) is a heterogeneous neoplastic disease that occurs by the growth of abnormal lymphoid and myeloid cells in the bone marrow and blood leading to acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL). Conventional cytogenetics is a characteristic technique to hunch chromosomal abnormalities, it helps in the diagnosis and therapeutic approach of the disease by the molecular cytogenetics technique of fluorescence in situ hybridization (FISH). Chromosomal abnormalities in AL are performed by karyotyping to confirm specific chromosomal abnormalities using FISH. The descriptive study included 42 clinically diagnosed AL patients. Karyotyping analysis was performed using the standard Giemsa banding procedure. To confirm specific chromosomal abnormalities and all culture failure (CF) cases, FISH was done. Among 42 cases, 29 (69.4%) males and 13 (30.9%) females, AML comprised 22 (52.38%) cases, ALL 14 (33.33%) cases, and AL 6 (14.2%) cases. Normal karyotype was found in 18 (42.85%), abnormal karyotype in 16 (39.09%), and 8 (19.09%) were CF. Specific abnormalities of t(15;17), hyperdiploidy; t(3;3) with monosomy 7 in; del(9q22); del(2p); del(17p); del(Xq); 1~2 dmin; der(3); +11, +13 and composite karyotype. Hypodiploidy was strongly associated with AL, which signifies the loss of chromosomes causing potential risk. Composite karyotype, rare t(3;3) double minutes, +11,+13, del(9q), and del(Xq) were the novel findings reported in the South Canara region of Karnataka. Despite other molecular techniques, conventional cytogenetics remains the baseline in the diagnosis of malignancies.

show abstract

Systematic Review of the Burden and Treatment Patterns of Adult and Adolescent Acute Lymphoblastic Leukemia in India: Comprehending the Challenges in an Emerging Economy

Radhakrishnan

Agrawal

Bagal

et al. 2021

Clinical Lymphoma Myeloma and Leukemia

View full text Add to dashboard Cite

Cytogenetics Findings of Patients With Acute Lymphoblastic Leukemia in West Indian Region.

Cited by 4 publications

References 14 publications

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients

Clinical Impact of CD25/CD123 Coexpression in Adult B-Cell Acute Lymphoblastic Leukemia Patients

Evaluation of the cytogenetic profile in patients with acute leukaemia

Systematic Review of the Burden and Treatment Patterns of Adult and Adolescent Acute Lymphoblastic Leukemia in India: Comprehending the Challenges in an Emerging Economy

Contact Info

Product

Resources

About