Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from <i>Penicillium citrinum</i>

Filho, José Williams Gomes de Oliveira; Andrade, Teresinha de Jesus Aguiar dos Santos; Lima, Róbson Borges de; Silva, Dulce Helena Siqueira; Reis, Antonielly Campinho dos; Santos, José Victor de Oliveira; Meneses, Ag-Anne Pereira Melo de; Carvalho, Rezanio Martins; Mata, Ana Maria Oliveira da; Alencar, Marcus Viní­cius Oliveira Barros de; Dias, Ana Carolina Soares; Silva, Felipe Cavalcanti Carneiro da; Islam, Muhammad Torequl; Clark, Cain C. T.; Sousa, João Marcelo de Castro e; Melo‐Cavalcante, Ana Amélia de Carvalho

doi:10.1080/01480545.2020.1769642

Cited by 6 publications

(5 citation statements)

References 83 publications

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“…[ 208 ], citrinin (CIT) and dicitrinin-A from Penicillium c . [ 209 ], allantopyrone E from Aspergillus v . [ 210 ], integracin A and B from Cytospora spp.…”

Section: Anticancer Activity Of Endophytic Fungimentioning

confidence: 99%

Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

et al. 2022

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Endophytic fungi are microorganisms that exist almost ubiquitously inside the various tissues of living plants where they act as an important reservoir of diverse bioactive compounds. Recently, endophytic fungi have drawn tremendous attention from researchers; their isolation, culture, purification, and characterization have revealed the presence of around 200 important and diverse compounds including anticancer agents, antibiotics, antifungals, antivirals, immunosuppressants, and antimycotics. Many of these anticancer compounds, such as paclitaxel, camptothecin, vinblastine, vincristine, podophyllotoxin, and their derivatives, are currently being used clinically for the treatment of various cancers (e.g., ovarian, breast, prostate, lung cancers, and leukemias). By increasing the yield of specific compounds with genetic engineering and other biotechnologies, endophytic fungi could be a promising, prolific source of anticancer drugs. In the future, compounds derived from endophytic fungi could increase treatment availability and cost effectiveness. This comprehensive review includes the putative anticancer compounds from plant-derived endophytic fungi discovered from 1990 to 2020 with their source endophytic fungi and host plants as well as their antitumor activity against various cell lines.

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“…[ 208 ], citrinin (CIT) and dicitrinin-A from Penicillium c . [ 209 ], allantopyrone E from Aspergillus v . [ 210 ], integracin A and B from Cytospora spp.…”

Section: Anticancer Activity Of Endophytic Fungimentioning

confidence: 99%

Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

et al. 2022

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“…In another study using yeast cells, CIT (400 µg/mL) induced the strong expression of 68 genes related to oxidative stress, suggesting toxicity triggered by CIT at high concentrations [ 64 ]. De Oliveira-Filho and collaborators [ 65 ] observed that citrinin can exert its toxic, cytotoxic, and mutagenic effects in yeast strains, possibly through oxidative stress induction. CIT’s cytotoxicity can be attributed to its role as an apoptosis inducer.…”

Section: Discussionmentioning

confidence: 99%

Advances in Antitumor Effects Using Liposomal Citrinin in Induced Breast Cancer Model

Moura,

de Menezes,

de Oliveira Filho

et al. 2024

Pharmaceutics

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The study aimed to evaluate the antitumor and toxicogenetic effects of liposomal nanoformulations containing citrinin in animal breast carcinoma induced by 7,12-dimethylbenzanthracene (DMBA). Mus musculus virgin females were divided into six groups treated with (1) olive oil (10 mL/kg); (2) 7,12-DMBA (6 mg/kg); (3) citrinin, CIT (2 mg/kg), (4) cyclophosphamide, CPA (25 mg/kg), (5) liposomal citrinin, LP-CIT (2 μg/kg), and (6) LP-CIT (6 µg/kg). Metabolic, behavioral, hematological, biochemical, histopathological, and toxicogenetic tests were performed. DMBA and cyclophosphamide induced behavioral changes, not observed for free and liposomal citrinin. No hematological or biochemical changes were observed for LP-CIT. However, free citrinin reduced monocytes and caused hepatotoxicity. During treatment, significant differences were observed regarding the weight of the right and left breasts treated with DMBA compared to negative controls. Treatment with CPA, CIT, and LP-CIT reduced the weight of both breasts, with better results for liposomal citrinin. Furthermore, CPA, CIT, and LP-CIT presented genotoxic effects for tumor, blood, bone marrow, and liver cells, although less DNA damage was observed for LP-CIT compared to CIT and CPA. Healthy cell damage induced by LP-CIT was repaired during treatment, unlike CPA, which caused clastogenic effects. Thus, LP-CIT showed advantages for its use as a model of nanosystems for antitumor studies.

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“…MpPhy , a gene encoding the photosensitive pigment phytochrome, is closely related to the growth of Monascus and the synthesis of secondary metabolites, such as CIT. , According to Zhang et al, CIT production in Monascus significantly decreases during liquid fermentation when exposed to blue light, and catalase activity also shows a consistent pattern. Its substrate, hydrogen peroxide, degrades CIT, suggesting that blue light may alter the metabolic pathway in Monascus , thereby controlling CIT . Yang et al.…”

Section: Control Of Cit Contamination In Cheese Productsmentioning

confidence: 99%

“…Its substrate, hydrogen peroxide, degrades CIT, suggesting that blue light may alter the metabolic pathway in Monascus, thereby controlling CIT. 140 Yang et al investigated the molecular mechanism of blue light on CIT and discovered a long noncoding RNA called AOANCR, which does not encode protein, however, it plays an important regulatory role in physiological and metabolic processes. 141 Additionally, Wang et not have a significant impact on CIT synthesis, and with the increase in light source intensity, an inhibitory effect began to appear, while low-intensity green light showed different effects that could stimulate CIT production.…”

Section: Use Of Essential Oilsmentioning

confidence: 99%

Occurrence, Risk Implications, Prevention and Control of CIT in Monascus Cheese: A Review

Zhang,

Cheng,

Qin

et al. 2024

J. Agric. Food Chem.

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Monascus is a filamentous fungus that has been used in the food and pharmaceutical industries. When used as an auxiliary fermenting agent in the manufacturing of cheese, Monascus cheese is obtained. Citrinin (CIT) is a well-known hepatorenal toxin produced by Monascus that can harm the kidneys structurally and functionally and is frequently found in foods. However, CIT contamination in Monascus cheese is exacerbated by the metabolic ability of Monascus to product CIT, which is not lost during fermentation, and by the threat of contamination by Penicillium spp. that may be introduced during production and processing. Considering the safety of consumption and subsequent industrial development, the CIT contamination of Monascus cheese products needs to be addressed. This review aimed to examine its occurrence in Monascus cheese, risk implications, traditional control strategies, and new research advances in prevention and control to guide the application of biotechnology in the control of CIT contamination, providing more possibilities for the application of Monascus in the cheese industry.

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Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum

Abstract: This document is the author's post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Cited by 6 publications

References 83 publications

Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

Putative Anticancer Compounds from Plant-Derived Endophytic Fungi: A Review

Advances in Antitumor Effects Using Liposomal Citrinin in Induced Breast Cancer Model

Occurrence, Risk Implications, Prevention and Control of CIT in Monascus Cheese: A Review

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