Cytogenotoxicity of the aqueous extract of Parquetina nigrescens leaf using Allium cepa assay

Alabi, Okunola A.; Atanda, Halimat Chisom; Olumurewa, John Alaba Victor

doi:10.1007/s00709-022-01741-6

Cited by 10 publications

(2 citation statements)

References 25 publications

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“…Volatile organic compounds isolated from the aqueous leaf extract of P. nigresens include 1, 2-benzenediol; 4H-pyran-4-one; 2, 3-dihydro-3,5-dihydroxy-6-methyl, and 5-hydroxymethylfurfural. These compounds have been found to produce cytogenotoxicity in some in-vitro studies [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

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“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Adase

Ankutse²,

Kumadoh

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The development of herbal medicines as a remedy for several illnesses has been recognized and accepted worldwide by health experts. Parquetina nigrescens is a perennial evergreen woody climber from the Apocynaceae family, widely used in Africa for the treatment of many diseases. The current study is intended to review and put together information available on this ethno-medicinal plant, which will improve scientific knowledge about the plant and also identify research areas that need to be investigated further. The information related to the plant was obtained using scientific databases such as Google scholar, WebMD, Wiley, Science direct, Cochrane database, student thesis, PubMed, and Scopus to obtain relevant literature regarding the botanical descriptions and distribution of the plant, traditional uses, phytochemicals, active compounds isolated from the plant, and pharmacological properties of P. nigrescens. Several traditional uses for different parts of the plant (leaves, stem bark, roots, leaf sap, flowers, and latex) have been presented. A review of the phytochemical composition of different plant parts revealed the presence of reducing sugars, flavonoids, tannins, alkaloids, cardiac glycosides, steroids, coumarin, anthraquinones, terpenoids, and saponins. Many studies also highlighted pharmacological activities related to P. nigrescens, including antianemic and haematological activity, antidiabetic, anti-inflammatory, antipyretic, analgesic, antiasthmatic, antimicrobial, insecticidal, neurotoxic, cytotoxic, antityphoid, antipolycystic ovarian syndrome activity, antilipidemic, and memory-enhancing activity. It is recommended that further in-vivo and clinical studies be conducted on the plant for the development of novel drugs.

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Section: Resultsmentioning

confidence: 99%

“…Cytogenotoxicity activity of P. nigrescens. Aqueous leaf extract of P. nigrescens has been investigated by Alabi and colleagues [ 46 ] on the root meristematic cells of Allium cepa for cytotoxic and genotoxic effects. Allium cepa was exposed to extract concentrations ranging from 1, 5, 10, 20, and 50%.…”

Section: Resultsmentioning

confidence: 99%

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Adase

Ankutse²,

Kumadoh

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Allium cepa as a Toxicogenetic Investigational Tool for Plant Extracts: A Systematic Review

Melo,

da Silva Pinheiro,

Costa

et al. 2024

Chemistry & Biodiversity

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Toxicological studies are important to investigate the genotoxic effects of various substances. Allium cepa can be used as test model for this purpose. This review summarizes the scope and applications for this A. cepa test model. For this, an up‐to‐date (April 2023) literature search was made in the Science Direct, PubMed, and Web of Science databases to find published evidence on studies performed using A. cepa as a test model. Out of 3,748 studies, 74 fit the inclusion criteria. The results showed that the use of the test model A. cepa contributed considerably to measuring the toxicological potential of plant extracts, proving the efficacy of the test as a potent bioindicator of toxic effects. In addition, 27 studies used more than one test system to verify the toxicological potential of extracts and fractions. Studies have shown that the A. cepa model has the potential to replace other test systems that make use of animals and cell cultures, besides having other advantages such as low cost, ease of execution, and good conditions for the observation of chromosomes. In conclusion, the A. cepa test can be considered one of the potential biomonitoring systems in toxicological studies of crude extracts.

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Cellular toxicity and DNA damage induced by Newbouldia laevis used for male infertility treatment in prokaryotic and eukaryotic models

et al. 2023

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Cytogenotoxicity of the aqueous extract of Parquetina nigrescens leaf using Allium cepa assay

Cited by 10 publications

References 25 publications

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Allium cepa as a Toxicogenetic Investigational Tool for Plant Extracts: A Systematic Review

Cellular toxicity and DNA damage induced by Newbouldia laevis used for male infertility treatment in prokaryotic and eukaryotic models

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