Cytoglobin attenuates melanoma malignancy but protects melanoma cells from ferroptosis
Zuquan Zou,
Qingyao Yu,
Yong Yang
et al.
Abstract:Cutaneous malignant melanoma is the most aggressive and the deadliest form of skin cancer. There are two types of limitations which universally exist in current melanoma therapy: Adverse effects and reduced efficiency. Cytoglobin (CYGB), an iron hexacoordinated globin, is highly enriched in melanocytes and frequently epigenetically silenced during melanoma genesis. The present study aimed to explore its potential role as a biomarker for ferroptosis treatment. It was observed that B16F10 and A375 melanoma cells… Show more
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