Cytographic changes on BC-6800 Haematological Analyzer related to the presence of<i>Candida albicans</i>in peripheral blood. A new tool to suspect candidemia?

Gioia, Antonio La; Devito, Alessandra; Fiorini, Fabiana; Bombara, M; Isola, Patrizia; Spinale, Barbara; Francioni, Lucia; Salamone, Domenico; Marelli, P; Buoro, Sabrina; Fiorini, Marcello

doi:10.1136/jclinpath-2016-204078

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…1,2 Accordingly, diagnostic support tools such as microscopic blood smear reviews (MBSR) and cytographic changes caused by yeasts in the counting channels of the automated hematology analyzers can be of great utility, since they can enable the rapid diagnosis of a fungemia when compared to the time-consuming blood cultures. 3,4 The cytographic information derived from the counting channels scattergrams of the Sysmex XN-3000 hematology analyzer may have a possible correlation with the morphological findings in the peripheral blood smear in cases of Candida parapsilosis sepsis.…”

Section: E T T E R T O T H E E D I T O R Early Detection Of Candida Parapsilosis Sepsis In Peripheral Blood As a Results Of Cytografic Chmentioning

confidence: 99%

Early detection of Candida parapsilosis sepsis in peripheral blood as a result of cytografic changes on the Sysmex XN‐3000 hematology analyzer

Comar

Spiri

Ferreira

et al. 2021

Int J Lab Hematology

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Section: E T T E R T O T H E E D I T O R Early Detection Of Candida Parapsilosis Sepsis In Peripheral Blood As a Results Of Cytografic Chmentioning

confidence: 99%

Early detection of Candida parapsilosis sepsis in peripheral blood as a result of cytografic changes on the Sysmex XN‐3000 hematology analyzer

Comar

Spiri

Ferreira

et al. 2021

Int J Lab Hematology

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Pseudo‐NRBC in the Mindray BC‐6800Plus analyzer: A clue for diagnostic anticipation of fungemia. Experimental and preliminary clinical reports

Zheng,

La Gioia,

Fiorini

et al. 2024

Int J Lab Hematology

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IntroductionCandidemia can be a significant cause of death in immunosuppressed or debilitated patients particularly. Abnormalities of the instrumental cytograms of some hematological analyzers, such as Mindray BC‐6800Plus, can be related to circulating Candida. We studied the possible diagnostic usefulness of this information.MethodsA fungal bloodstream infection has been simulated by adding aliquots of Candida albicans, Candida parapsilosis, and Candida glabrata to 75 leftovers and anonymized peripheral blood samples. Cytographic abnormalities like those of experimental samples were used to select patients with possible fungemia. The microscopic review of peripheral blood smears constituted the confirmatory method.ResultsIn all experimental samples, the various Candida types caused pseudo‐NRBC and morphological abnormalities of WNB and DIFF cytograms. Circulating blastospores, free or engulfed by neutrophils, were the microscopic findings in the peripheral blood smears.In the clinical verification, 72 patients were recruited based on the presence of an evocative cluster in the WNB and DIFF cytograms. The microscopic review of 39 out of 72 samples was positive for NRBC. According to blood cultures, light microscopy revealed fungal forms of several Candida or non‐Candida types in the remaining 33 samples. Nine of these cases were not yet known to suffer from bloodstream infection.ConclusionsAlthough further confirmatory clinical studies are required for these diagnostic abilities, the BC 6800Plus cytographic abnormalities related to fungemia have proven helpful in rapidly monitoring persistent fungemia in already diagnosed patients. In unknown or undiagnosed cases, they could be the trigger point for the subsequent diagnostic‐therapeutic pathway.

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Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review

Gioia¹,

Basile

Fiorini

et al. 2022

Clinical Chemistry and Laboratory Medicine (CCLM)

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Cytographic changes on BC-6800 Haematological Analyzer related to the presence ofCandida albicansin peripheral blood. A new tool to suspect candidemia?

Abstract: Our observations suggest that the results of the BC-6800, which are due to ' presence, might be useful to speculate earlier diagnosis of sepsis.

Cited by 4 publications

References 20 publications

Early detection of Candida parapsilosis sepsis in peripheral blood as a result of cytografic changes on the Sysmex XN‐3000 hematology analyzer

Early detection of Candida parapsilosis sepsis in peripheral blood as a result of cytografic changes on the Sysmex XN‐3000 hematology analyzer

Pseudo‐NRBC in the Mindray BC‐6800Plus analyzer: A clue for diagnostic anticipation of fungemia. Experimental and preliminary clinical reports

Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review

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