Cytokeratin Profile of Extrahepatic Pancreaticobiliary Epithelia and Their Carcinomas

Alexander, J. H.; Krishnamurthy, Savitri; Kovacs, Douglas; Dayal, Yogeshwar

doi:10.1097/00022744-199712000-00002

Cited by 19 publications

(16 citation statements)

References 19 publications

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“…The morphological findings are consistent with pancreatic adenocarcinoma with lymph node metastasis [21]. The immunohistochemical stains performed on the pancreatic biopsy and peripancreatic lymph node (Table I) show no neuroendocrine differentiation and are compatible with ductal adenocarcinoma [22]. Biopsies from omental metastases in 1997 (Fig.…”

Section: Pathologysupporting

confidence: 52%

Twelve-year survival after the diagnosis of locally advanced carcinoma of the pancreas: A case report

et al. 2000

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The long-term survival rate of patients with carcinoma of the pancreas is low. Even more so, long-term survival of patients with metastatic pancreatic carcinoma is extremely rare. In this case report, we describe a patient with an unusual course of disease. This patient was diagnosed with locoregional carcinoma of the pancreas and therefore underwent gastroenterostomy and cholecystojeojenostomy without resection of the primary tumor. Later he was treated with radiotherapy and chemotherapy and survived 12 years, during 11 of which he had no evidence of disease. He died 12 years after the initial diagnosis from peritoneal dissemination of poorly differentiated carcinoma complicated with obstructive jaundice and sepsis. To our knowledge, this patient had the longest reported survival with locally advanced pancreas carcinoma that was not resected. The case is presented and discussed in this article.

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Section: Pathologysupporting

confidence: 52%

Twelve-year survival after the diagnosis of locally advanced carcinoma of the pancreas: A case report

et al. 2000

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“…Various immunohistochemical markers have been advocated for the identification of hepatobiliary and pancreatic neoplasms and include ␣-fetoprotein, carcinoembryonic antigen (1), albumin (4), CKs 7,8,18,19,and 20 (1,5-7), MOC31 (12), and HepPar 1 (13,14). These markers are most useful when applied as a part of a panel, and some have limitations.…”

Section: Discussionmentioning

confidence: 99%

“…Another widely used marker, polyclonal carcinoembryonic antigen, has been shown to demonstrate a bile can-alicular pattern in HCC and a diffuse cytoplasmic pattern without canalicular accentuation in adenocarcinomas (16). Various cytokeratins have also been used to help differentiate between HCC and adenocarcinomas and determine the site of tumor origin (7,18,19). Also, occasional cases of HCC that exhibited an overall bile canalicular pattern have been shown to demonstrate foci of cytoplasmic or luminal (pseudoglandular areas) staining, whereas some cases of adenocarcinoma can have foci that resemble a bile canalicular pattern (12).…”

Section: Discussionmentioning

confidence: 99%

“…Various immunohistochemical markers have been advocated for the separation of hepatobiliary and pancreatic neoplasms and include ␣-fetoprotein, ␣-1-antitrypsin, carcinoembryonic antigen (1), factor XIIIa (2), ferritin (3), albumin (4), and CKs 7,8,18,19,and 20 (1,[5][6][7]. Cytokeratin 5/6 antibody, which recently became commercially available, has been found useful in the diagnosis of mesothelioma.…”

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confidence: 99%

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Vlasoff¹,

Baschinsky²,

Frankel³

2002

APPL. IMMUNOHISTOCHEM.

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“…Thus, the possibility of intraductal-type pTis cancers, in the papillary region, should always be considered when searching for the cause of Based on the assumption that the main lesion location is also the primary tumor site, our immunohistochemical investigation showed that the primary site may be predicted based on the morphological features determined from the endoscopic appearance. Recently, CK staining has been widely used to locate the primary cancer site; CKs often reveal the nature of the primary site, even after the lesion has become cancerous, so the identification of the primary cancer site using these traits has been examined (15,16). Based on immunohistochemical staining for CKs, intestinal epithelial and pancreatobiliary duct epithelial origins of papillary cancers have been reported.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic papillectomy for carcinoma of the ampulla of Vater: Possible standardization based on endoscopy and immunohistochemistry

Hamada

Maeshiro²,

Nakayama³

2014

Turk J Gastroenterol

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Background/Aims: Clinicopathological investigation of the indications for the use of endoscopic papillectomy as a treatment for carcinoma in situ of the ampulla of Vater (CAV). Materials and Methods: Of 97 patients diagnosed with CAV in our department over the last 15 years, the 5 patients who received a carcinoma in situ diagnosis and were included in this retrospective study. Results: The lesions in the patients were classified as either the superficial or luminal type, based on endoscopic findings. Histological findings showed that the major duodenal papilla (Ad) was the main site of CAV in the superficial type and that the common duct into the duodenal lumen (Ac) was the primary site in the luminal type. Immunohistochemical staining showed that the superficial-type lesions were positive for cytokeratin 20, suggesting development of the cancer from the Ad. The luminal-type lesion was positive for cytokeratin 7 and negative for cytokeratin 20, suggesting an origin in the pancreatobiliary duct. Mucin-2 was expressed in the superficial type, and mucin-1 in the luminal type. Conclusion: Superficial-type lesions, which are principally located in the Ad, exhibit little tendency to invade surrounding tissues, whereas the luminal-type lesions, which are predominantly located in the Ac, may tend to be more invasive. Although endoscopic papillectomy might be indicated for the superficial-type lesions, caution is needed in the determination of the extent of luminal-type lesions.

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Cytokeratin Profile of Extrahepatic Pancreaticobiliary Epithelia and Their Carcinomas

Cited by 19 publications

References 19 publications

Twelve-year survival after the diagnosis of locally advanced carcinoma of the pancreas: A case report

Twelve-year survival after the diagnosis of locally advanced carcinoma of the pancreas: A case report

Untitled

Endoscopic papillectomy for carcinoma of the ampulla of Vater: Possible standardization based on endoscopy and immunohistochemistry

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