Cytokeratins 8, 18 and 19 in endometrial epithelial cells during the normal menstrual cycle and in women receiving Norplant®

Expression of Cytokeratin 8 (CK8) in Human Endometrium and Endometriosis

“…On the other hand, it is also known for example that the keratin 8/18 dimer has a key function in tumor necrosis factor (TNF)-mediated apoptosis [12]. Previously published data concerning cytokeratin expression in eutopic endometrium, like the results of the present study, have not demonstrated any dependency on the phase of the menstrual cycle [2,3]. The reduction of cytokeratin expression by levonorgestrel reported by Wonodirekso et al is not necessarily in contradiction with this.…”

“…The reduction of cytokeratin expression by levonorgestrel reported by Wonodirekso et al is not necessarily in contradiction with this. The more complex activity profile of the synthetic gestagen levonorgestrel -as a nortestosterone derivative that also has a partial androgenic effect in comparison with natural progesterone -may be the reason for the different effect on cytokeratin expression [3]. On the other hand, the sufficiently well-known discrepancy in hormone receptor expression between eutopic endometrium, adenomyosis, and peritoneal endometriosis may explain the differences in cytokeratin expression observed in this study.…”

“…The cytokeratin (CK) isotypes depend on the cell type and localization in the cytoplasm [1]. Although cytokeratin expression does not appear to be influenced by the natural menstrual cycle, synthetic progestogens appear to reduce cytokeratin expression in human endometrium [2,3]. In endometrial cancer and cervical intraepithelial neoplasia/cervical squamous cell carcinoma, the expression of cytokeratins correlates with aggressive tumor features, lesion grade, and the International Federation of Gynecology and Obstetrics (FIGO) stage [4,5].…”

Complications of Subcutaneous Contraception: A Review

“…The progesterone-exposed endometrium has less vascular support from the pericytes because the vascular smooth muscle is reduced [ 15 ]. Norplant also interacts with cytokeratin in the endometrial epithelium, making the blood vessels more fragile, causing them to leak into the endometrial cavity [ 16 ].…”

Expression of kisspeptin and matrix metalloproteinases in human endometrial culture: a study of invasive and migratory properties

“…По данным s. Wonodirekso, цитокератин-8 -это цитоплазматический белок, являющийся специфическим маркером клеток однослойного плоского эпителия. Число железистых клеток варьировало от образца к образцу (S экссK-8 = 5,72-38,29 %) [22].…”