1997
DOI: 10.1093/gerona/52a.2.b93
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Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity

Abstract: Host responses to infectious and inflammatory stimuli are altered with aging. Because cytokines and their antagonists are significant factors in these host responses, the present research on aged subjects was designed to investigate plasma concentrations of the cytokines interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) and those of their antagonists IL-1 receptor antagonist (IL-1ra) and soluble TNF receptor (sTNFr). For this research, 122 apparently healthy aged subjects (79.6 +/- 5.8… Show more

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Cited by 74 publications
(36 citation statements)
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“…Nevertheless, the lack of any significant change in the resting concentration of these cytokines could be due to the fact that the cytokine concentrations were not as high as those reported in other older populations. 23,24 It was interesting to note that IL-6 and TNF-a did not change after the acute bout of resistance exercise at week 10, whereas these cytokines increased after the acute bout at week 20. It is likely that the inclusion of eccentric muscle contractions during the second bout of exercise caused more muscle damage, resulting in greater synthesis of IL-6 and TNF-a.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, the lack of any significant change in the resting concentration of these cytokines could be due to the fact that the cytokine concentrations were not as high as those reported in other older populations. 23,24 It was interesting to note that IL-6 and TNF-a did not change after the acute bout of resistance exercise at week 10, whereas these cytokines increased after the acute bout at week 20. It is likely that the inclusion of eccentric muscle contractions during the second bout of exercise caused more muscle damage, resulting in greater synthesis of IL-6 and TNF-a.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, studies have reported increased circulating levels of neopterin (8), TNF-␣ (4), sTNFR (4,8), and acute-phase proteins (1) in elderly persons as well as increased unstimulated production of IL-1␤ (13), IL-6, and IL-1ra (14) in vitro.…”
Section: Discussionmentioning
confidence: 99%
“…Blood was drawn before and 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h after injection for differential WBC counts and hemoglobin as well as for isolation of serum and plasma. Blood for other chemical analyses of liver and kidney function was drawn before and 4,8,12, and 24 h after injection.…”
Section: Methodsmentioning
confidence: 99%
“…These possibilities are now beginning to be explored (for factors in addition to sIL 2R mentioned above). Thus, Catania et al (253) reported a study of 122 healthy aged compared to 39 unhealthy (urinary tract infections) and 100 young controls regarding plasma levels of IL 1R-antagonist and sTNF-R. These were higher in the healthy old than in young controls, and were even higher in the infected subjects.…”
Section: Cytokine Production and Responsementioning
confidence: 99%
“…These findings were more extreme in patients with infections. It was therefore suggested that subclinical infections may have been responsible for this even in apparently healthy elderly donors (253). Indeed, the production of factors such as IL 6 is clearly influenced by health status, even in "near-SENIEUR" donors (254).…”
Section: Cytokine Production and Responsementioning
confidence: 99%