2021
DOI: 10.3390/pathogens10050527
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Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia

Abstract: Nephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic of Tatarstan (RT) and the Republic of Mordovia (RM), is a mild form of hemorrhagic fever with renal syndrome caused by infection with rodent-borne orthohantaviruses. Although NE cases have been reported for decades, little is known about the hantavirus strains associated with human infection in these regions. There is also limited understanding of the pathogenesis of NE in the RT and the RM. To address these knowled… Show more

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Cited by 13 publications
(9 citation statements)
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“…Simultaneous activation of the adaptive immune response through T H and T C cells, and subsequent secretion of interleukin (IL)‐12 and IL‐4‐dependent signaling provides effective Th1/Th2 balance against invading pathogens (Nash & Dutia, 2010). However, the dysregulated immune response has been reported in several viral infections such as influenza, Ebola, hantavirus, and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) which leads to severe symptoms such as anaphylactic shock, trauma, local tissue damage, and multi‐organ failure (Jain, Khaiboullina, & Baranwal, 2020; Martynova et al, 2021; Tang et al, 2020; Tisoncik et al, 2012; Younan et al, 2017). Subjects with comorbidities such as obesity, cardiometabolic diseases, type II diabetes, and non‐alcoholic fatty liver disease with underlying chronic “low‐grade” inflammation are at higher risk of hyperimmune response during viral infections.…”
Section: Introductionmentioning
confidence: 99%
“…Simultaneous activation of the adaptive immune response through T H and T C cells, and subsequent secretion of interleukin (IL)‐12 and IL‐4‐dependent signaling provides effective Th1/Th2 balance against invading pathogens (Nash & Dutia, 2010). However, the dysregulated immune response has been reported in several viral infections such as influenza, Ebola, hantavirus, and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) which leads to severe symptoms such as anaphylactic shock, trauma, local tissue damage, and multi‐organ failure (Jain, Khaiboullina, & Baranwal, 2020; Martynova et al, 2021; Tang et al, 2020; Tisoncik et al, 2012; Younan et al, 2017). Subjects with comorbidities such as obesity, cardiometabolic diseases, type II diabetes, and non‐alcoholic fatty liver disease with underlying chronic “low‐grade” inflammation are at higher risk of hyperimmune response during viral infections.…”
Section: Introductionmentioning
confidence: 99%
“…This retrospective PUUV patient cohort study aimed to identify biomarkers associated with more severe disease in terms of platelet count and kidney injury. IL-18 is an important pro-inflammatory cytokine often found to be upregulated in PUUV patients compared to healthy controls, indicating a role in pathogenesis [ 12 , 13 , 14 , 15 ]. In the current study, IL-18 was significantly higher in patients in the low platelet group.…”
Section: Discussionmentioning
confidence: 99%
“…Cellular antiviral response may account for differences in infection kinetics and may influence the clinical course and disease severity of viral infections. Differences in the individual immune response in patients infected with PUUV were observed [ 60 , 61 ]. Behavioral factors (e.g.…”
Section: Discussionmentioning
confidence: 99%