Cytokine database of stress and metabolic disorders (CdoSM): a connecting link between stress and cardiovascular disease, hypertension, diabetes and obesity

Bhasin, Eshan; Mishra, Shivam; Pathak, Geetansh; Chauhan, Param Singh; Kulshreshtha, Akanksha

doi:10.1007/s13205-022-03375-0

Cited by 4 publications

(2 citation statements)

References 75 publications

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“…In line with the dendritic count results, when assessing the overall length of the dendrites [F (3,196)…”

Section: Effects Of Avs and Emdr Stimulation On Hippocampal Dendritic...mentioning

confidence: 56%

“…Stress represents a significant health challenge, triggering physiological responses that encompass various bodily systems, including metabolism, immune response, and reproduction (1)(2)(3)(4). The brain exhibits remarkable adaptive capabilities through neuroplastic changes, including modifications in dendritic and synaptic morphology, allowing for dynamic responses to internal and external stimuli (5).…”

Section: Introductionmentioning

confidence: 99%

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Visual EMDR stimulation mitigates acute varied stress effects on morphology of hippocampal neurons in male Wistar rats

Ruvalcaba-Delgadillo,

Martínez-Fernández,

Luquin

et al. 2024

Front. Psychiatry

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IntroductionStress is a pervasive health concern known to induce physiological changes, particularly impacting the vulnerable hippocampus and the morphological integrity of its main residing cells, the hippocampal neurons. Eye Movement Desensitization and Reprocessing (EMDR), initially developed to alleviate emotional distress, has emerged as a potential therapeutic/preventive intervention for other stress-related disorders. This study aimed to investigate the impact of Acute Variable Stress (AVS) on hippocampal neurons and the potential protective effects of EMDR.MethodsRats were exposed to diverse stressors for 7 days, followed by dendritic morphology assessment of hippocampal neurons using Golgi-Cox staining.ResultsAVS resulted in significant dendritic atrophy, evidenced by reduced dendritic branches and length. In contrast, rats receiving EMDR treatment alongside stress exposure exhibited preserved dendritic morphology comparable to controls, suggesting EMDR’s protective role against stressinduced dendritic remodeling.ConclusionsThese findings highlight the potential of EMDR as a neuroprotective intervention in mitigating stress-related hippocampal alterations.

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“…In line with the dendritic count results, when assessing the overall length of the dendrites [F (3,196)…”

Section: Effects Of Avs and Emdr Stimulation On Hippocampal Dendritic...mentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Visual EMDR stimulation mitigates acute varied stress effects on morphology of hippocampal neurons in male Wistar rats

Ruvalcaba-Delgadillo,

Martínez-Fernández,

Luquin

et al. 2024

Front. Psychiatry

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Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases)

Ullah,

Singla,

Batool

et al. 2024

Rev Endocr Metab Disord

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Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets

Chen,

Ullah,

Chen

et al. 2024

Mol Med

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Pelvic organ prolapse (POP) and urinary incontinence (UI) are common disorders that significantly impact women’s quality of life. Studies have demonstrated that cytokines, including pro- and anti-inflammatory immune mediators, play a role in illness genesis and progression. Research on the inflammatory milieu of the pelvic floor has shown that POP patients have increased inflammation in vaginal tissues. This evidence revealed that significant changes in the inflammatory milieu of the pelvic floor are an aspect of the pathogenesis of POP. POP patients exhibit increased levels of inflammatory cytokines (IL-1, TNF, IFN, and others) in the front vaginal wall, which may alter collagen metabolism and contribute to POP. Studies indicate that cytokines such as IL-6, IL-10, and TGF, which are involved in inflammation, remodelling, and repair, have dual effects on POP and UI. They can promote tissue healing and regeneration but also exacerbate inflammation and fibrosis, contributing to the progression of these conditions. Understanding the dual roles of these cytokines could help us improve the vaginal microenvironment of women and treat POP and UI. Given the considerable changes in these cytokines, this review addresses studies published between 2000 and 2024 on the molecular mechanisms by which pro- and anti-inflammatory cytokines affect women with POP and UI. Furthermore, we explain novel therapeutic strategies for cytokine regulation, emphasizing the possibility of personalized treatments that address the underlying inflammatory milieu of the vagina in POP and UI patients. This thorough analysis aims to establish a foundation for future research and clinical applications, ultimately improving patient outcomes via designed cytokine-based therapies.

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Cytokine database of stress and metabolic disorders (CdoSM): a connecting link between stress and cardiovascular disease, hypertension, diabetes and obesity

Cited by 4 publications

References 75 publications

Visual EMDR stimulation mitigates acute varied stress effects on morphology of hippocampal neurons in male Wistar rats

Visual EMDR stimulation mitigates acute varied stress effects on morphology of hippocampal neurons in male Wistar rats

Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases)

Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets

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