Cytokine diagnosis of pleural TB: will it stand the test of time?

Tebruegge, Marc; Elkington, Paul

doi:10.1136/thoraxjnl-2017-210918

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Meanwhile, although the performance of other biochemical indexes, such as adenosine deaminase (ADA), seems to show a great value particularly in specificity, there are still a certain number of missed and misdiagnosed cases (Gui and Xiao, 2014;Valdes et al, 1996). Besides, evidence from recent studies suggested that interleukin-27 (IL-27) and other cytokines had a potential value in this field (Klimiuk et al, 2015;Qin et al, 2005;Wang et al, 2018;Wong et al, 2003), but they were only evaluated in a small scale and the true value is controversial (Tebruegge and Elkington, 2018). These all lead to delayed or missed diagnosis with increasing morbidity and mortality, or over diagnosis leading to unnecessary anti-TB treatment.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of pleural fluid T-SPOT and interferon-gamma for tuberculous pleurisy: A two-center prospective cohort study in China

Luo

Feng²,

Xue

et al. 2020

International Journal of Infectious Diseases

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Background: Early and accurate diagnosis of tuberculous pleurisy (TP) remains a challenge. The aim of the present study is to evaluate the performance of the pleural fluid (PF) T-SPOT and interferon-gamma (IFNg) for TP diagnosis in high tuberculosis (TB) burden settings. Methods: In total, 214 and 217 subjects suspected of TP were prospectively enrolled in the Wuhan (training) cohort and Changchun (validation) cohort, respectively. All patients were examined with PF T-SPOT, IFN-g, and other traditional tests simultaneously. Results: The receiver-operating characteristic (ROC) curve analysis showed that the area under the curve (AUC), sensitivity, and specificity of TB-specific antigen (TBAg) spot-forming cells (SFC) (the larger of early secreted antigenic target 6 and culture filtrate protein 10 SFC in PF T-SPOT assay) for TP diagnosis were 0.972, 92.86%, and 92.16%, respectively, with a cutoff value of 35 in the Wuhan cohort. Meanwhile, when a threshold value of 95 ng/mL was set, the AUC, sensitivity, and specificity of IFN-g to diagnose TP were 0.951, 86.61%, and 90.20%, respectively. Moreover, the diagnostic model based on the combination of TBAg SFC and IFN-g showed an AUC of 0.983 for differentiating TP from non-TP, with 95.54% sensitivity and 95.10% specificity when a cutoff value of 0.32 was used in the Wuhan cohort. Excellent diagnostic accuracy was also observed in the Changchun cohort. When applying the cutoff value obtained from the Wuhan cohort, the AUC, sensitivity, and specificity of the diagnostic model were 0.995, 95.08%, and 97.89%, respectively. Conclusions: The performance of PF T-SPOT was comparable to IFN-g in diagnosing TP. However, using the diagnostic model established by the combination of these two assays can achieve a more accurate diagnosis of TP.

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Section: Introductionmentioning

confidence: 99%

Diagnostic utility of pleural fluid T-SPOT and interferon-gamma for tuberculous pleurisy: A two-center prospective cohort study in China

Luo

Feng²,

Xue

et al. 2020

International Journal of Infectious Diseases

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Pleural Diseases: Pleurodesis via Indwelling Pleural Catheter, Dasatinib-induced Pleural Effusion, and IL-27 in Tuberculosis Pleural Effusion

Sagar

Dodge

Salahuddin

et al. 2019

Am J Respir Crit Care Med

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ЗНАЧЕНИЕ ОТДЕЛЬНЫХ Клинико-Анамнестических ДАННЫХ В ФОРМИРОВАНИИ ТУБЕРКУЛЕЗА ВНЕЛЕГОЧНЫХ ЛОКАЛИЗАЦИЙ У ДЕТЕЙ, "Вестник Центрального Научно-Исследовательского Института Туберкулеза"

Поркулевич¹

2019

Вестник ЦНИИТ

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К основным факторам риска заболевания детей туберкулезом (ТБ) относят: выраженную и гиперергическую чувствительность к туберкулину, проживание в социопатических семьях и семьях медико-демографического риска, контакт с больными ТБ, наличие сопутствующих заболеваний, первичное инфицирование, отсутствие или некачественную вакцинацию БЦЖ. В то же время практически отсутствуют работы, отражающие значение отдельных факторов риска в формировании ТБ внеторакальных локализаций. В статье на основании анализа анамнестических и клинических данных, социального статуса семей и эпидемиологического анамнеза выделены наиболее важные факторы риска развития внелегочных форм ТБ среди детского населения Омской области.

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Cytokine diagnosis of pleural TB: will it stand the test of time?

Cited by 3 publications

References 19 publications

Diagnostic utility of pleural fluid T-SPOT and interferon-gamma for tuberculous pleurisy: A two-center prospective cohort study in China

Diagnostic utility of pleural fluid T-SPOT and interferon-gamma for tuberculous pleurisy: A two-center prospective cohort study in China

Pleural Diseases: Pleurodesis via Indwelling Pleural Catheter, Dasatinib-induced Pleural Effusion, and IL-27 in Tuberculosis Pleural Effusion

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