Cytokine gene polymorphisms in patients infected with hepatitis B virus

Ben‐Ari, Ziv; Mor, Eytan; Papo, Orit; Kfir, B.; Sulkes, Jaqueline; Tambur, Anat R.; Tur–Kaspa, Ran; Klein, Tirza

doi:10.1111/j.1572-0241.2003.07179.x

Cited by 201 publications

(130 citation statements)

References 35 publications

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“…Combined therapy with ribavirin and IFN-a for chronic hepatitis B not only significantly reduces viremia levels but also induces lasting CD4 + T cell proliferation and Th1 cytokine release at the site of infection [14]. It was also suggested that healthy individuals who recovered from HBV infection had a distribution of IFN-c gene polymorphism similar to healthy controls; however, the majority of the chronic patients exhibited the potential to produce low levels of IFN-c [2]. The e protein triggers a T cell-dependent immune response, while the core protein triggers both T cell-independent and T cell-dependent immune responses.…”

Section: Discussionmentioning

confidence: 96%

Anti-hepatitis B surface antigen IgG1 subclass is predominant in individuals who have recovered from hepatitis B virus infection, chronic carriers and vaccinees

Wang

Lin

Tsai

et al. 2004

Med Microbiol Immunol

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Patterns of each IgG-specific subclass for hepatitis B virus (HBV) core antigen (anti-HBc) are remarkably different among individuals with different infection status, i.e., completely recovered or chronic carrier. Each of the IgG-specific subclasses of HBV surface antigen (anti-HBs) was tested for ELISA sensitivity using four commercially available hepatitis B surface antigen (HBsAg) kits and one self-prepared plate. The specificity in 18 serum samples obtained from chronic HBV carriers, recovered individuals, vaccinees and non-infected individuals was investigated. Differences in absorbance values were obtained by comparing results from these different plates. Data on the absorbance values of anti-HBs IgG subclasses obtained indicated that one to four subjects had a false-negative or false-positive result using the four commercial plates. Only the self-prepared plate demonstrated 100% specificity and sensitivity for anti-HBs subclasses. Moreover, the results indicate that anti-HBs subclass IgG1 was predominant in cured patients, chronic carriers and vaccinees. The samples from both chronic carriers and vaccinees exhibited a significantly higher concentration of total IgG and IgG1 than samples in recovered individuals (P<0.05).

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Section: Discussionmentioning

confidence: 96%

Anti-hepatitis B surface antigen IgG1 subclass is predominant in individuals who have recovered from hepatitis B virus infection, chronic carriers and vaccinees

Wang

Lin

Tsai

et al. 2004

Med Microbiol Immunol

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“…Cytokines play a key role in the regulation of the immune response and the capacity of cytokine production differs among individuals and correlates with the polymorphism in the cytokine gene promoters (Ben-Ari et al, 2003). Host resistance to Brucella has been mainly studied in mice and shown that cytokines control the immune response and influence the outcome of the disease (Baldwin and Parent, 2002).…”

Section: Discussionmentioning

confidence: 99%

Study the Impact of T-helper 1 Cytokine (TNF-α) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah Region

Ismael¹,

Mergani²,

Mostafa³

et al. 2016

American Journal of Infectious Diseases

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Polymorphisms in the regulatory regions of cytokine genes may not only increase susceptibility to some infectious diseases but also affect the course and prognosis of the disease. TNF-α is considered an important Th1 cytokines that plays critical roles in control of Brucella infection and in macrophage activation. In this study, we are going to analyze the relationship of two polymorphisms in TNF-α and the inherited susceptibility/resistance to brucellosis in population of Makkah region. A cases-control association study was conducted in 69 individuals with human Brucellosis and 112 healthy individuals. Genotyping of TNF-308G>A and -857C>T polymorphism in both patients and healthy controls was done by PCR-RFLP method and were assessed for potential associations with susceptibility for human brucellosis and their mode of penetrance. The findings indicate an increased risk of TNF-α-308 A allele for human brucellosis reliable with the recessive genetic model of penetrance (Odd Ratio: 3.222, 95% CI: 1.008-5.702, P = 0.018). There is no association between susceptibility of human brucellosis and TNF-α-857 C/T polymorphism was observed. The protective role of TNF-α-857 C/T polymorphism against human brucellosis in this study population could not be excluded.

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“…Tseng et al (2006) demonstrated that the -592G/A variant affects HCC risk, while Qiu et al (2011) reported that certain genotypes of the -819 and -592 SNPs increase and decrease susceptibility, respectively. Furthermore, Truelove et al (2008) suggested that IL-10 gene sequence variations influence HBV infection outcome, although Ben-Ari et al (2003) reported that the polymorphisms investigated in the current study are not associated with development of chronic HBV infection and related diseases. Finally, Heneghan et al (2003) conducted a study among the Hong Kong Chinese population, finding that IL-10 polymorphisms do not contribute to HCC susceptibility.…”

Section: Discussionmentioning

confidence: 75%

“…Yang and Fa (2015) indicated that IL-10 -1082A/G constitutes a candidate biomarker for the prediction of susceptibility to esophageal cancer, while Vinod et al (2015) suggested that the AA genotype of this SNP correlates with breast cancer oncogenesis in the South Indian population. Several previous studies have examined the association between IL-10 gene polymorphisms and development of HCC (Ben-Ari et al, 2003;Heneghan et al, 2003;Tseng et al, 2006;Truelove et al, 2008;Qiu et al, 2011;Wei et al, 2011). Tseng et al (2006) demonstrated that the -592G/A variant affects HCC risk, while Qiu et al (2011) reported that certain genotypes of the -819 and -592 SNPs increase and decrease susceptibility, respectively.…”

Section: Discussionmentioning

confidence: 99%

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/ C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain reaction-restriction fragment length polymorphism assay was applied to assess the sequence variants of interest. Compared with control subjects, HCC patients were more likely to be older (t = 1.94, P = 0.03), have a family history of cancer (chi square = 17.86, P < 0.001), and exhibit higher alanine transaminase (t = 13.32, P < 0.001) and aspartate transaminase (t = 12.63, P < 0.001) levels. Using unconditional logistic regression analyses, we found that the GG genotype of -592G/A was associated with increased risk of HCC [odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.12-4.38], compared to the AA genotype. Under a dominant model, the AG+GG genotype correlated with HBV-related HCC susceptibility compared to the AA genotype, with an OR (95%CI) of 1.56 (1.02-2.48). Moreover, a recessive model showed the GG genotype to be associated with elevated risk of HCC compared to the AA+AG genotype (OR = 1.85, 95%CI = 1.01-3.47). However, no significant association between the -819T/C and -1082A/C variants and development of HBV-related HCC was observed under codominant, dominant, and recessive models. We conclude that the IL-10 -592G/A polymorphism does play a role in susceptibility to HBV-related HCC under codominant, dominant, and recessive models.

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Cytokine gene polymorphisms in patients infected with hepatitis B virus

Abstract: These findings suggest an association between the genetic ability to produce low levels of IFN-gamma and the susceptibility to develop chronic HBV infection.

Cited by 201 publications

References 35 publications

Anti-hepatitis B surface antigen IgG1 subclass is predominant in individuals who have recovered from hepatitis B virus infection, chronic carriers and vaccinees

Anti-hepatitis B surface antigen IgG1 subclass is predominant in individuals who have recovered from hepatitis B virus infection, chronic carriers and vaccinees

Study the Impact of T-helper 1 Cytokine (TNF-α) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah Region

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

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Cytokine gene polymorphisms in patients infected with hepatitis B virus

Abstract: These findings suggest an association between the genetic ability to produce low levels of IFN-gamma and the susceptibility to develop chronic HBV infection.

Cited by 201 publications

References 35 publications

Anti-hepatitis B surface antigen IgG1 subclass is predominant in individuals who have recovered from hepatitis B virus infection, chronic carriers and vaccinees

Anti-hepatitis B surface antigen IgG1 subclass is predominant in individuals who have recovered from hepatitis B virus infection, chronic carriers and vaccinees

Study the Impact of T-helper 1 Cytokine (TNF-&alpha;) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah Region

Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma

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Study the Impact of T-helper 1 Cytokine (TNF-α) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah Region