Cytokine gene polymorphisms in periodontal disease: a meta‐analysis of 53 studies including 4178 cases and 4590 controls

Nikolopoulos, Georgios K.; Dimou, Niki; Hamodrakas, Stavros J.; Bagos, Pantelis G.

doi:10.1111/j.1600-051x.2008.01298.x

Cited by 159 publications

(171 citation statements)

References 103 publications

(142 reference statements)

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“…A recent study also reviewed the association between the IL-6 −174 G/C polymorphism and periodontitis (Nikolopoulos et al, 2008). It is difficult to compare their results directly with ours for three reasons.…”

Section: Discussionmentioning

confidence: 79%

Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis

Shao

Huang

Cheng

et al. 2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. Material and methods: We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 −174 G/C and −572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 −6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well. Results and conclusion: The present meta-analysis indicates that the IL-6 −174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And −572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.

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Section: Discussionmentioning

confidence: 79%

Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis

Shao

Huang

Cheng

et al. 2009

J. Zhejiang Univ. Sci. B

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“…Among the principal genetic variants pointed out from literature, 2,46 for the present study, we decided to focus our attention on the 28 candidate gene polymorphisms, located within 14 different genes, described in Table 2, and to investigate their relation with AgP susceptibility.…”

Section: Genotyping and Snps Selectionmentioning

confidence: 99%

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

et al. 2011

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Aggressive periodontitis (AgP) is a multifactorial disease. The distinctive aspect of periodontitis is that this disease must deal with a large number of genes interacting with one another and forming complex networks. Thus, it is reasonable to expect that gene-gene interaction may have a crucial role. Therefore, we carried out a pilot case-control study to identify the association of candidate epistatic interactions between genetic risk factors and susceptibility to AgP, by using both conventional parametric analyses and a higher order interactions model, based on the nonparametric Multifactor Dimensionality Reduction algorithm. We analyzed 122 AgP patients and 246 appropriate periodontally healthy individuals, and genotyped 28 polymorphisms, located within 14 candidate genes, chosen among the principal genetic variants pointed out from literature and having a role in inflammation and immunity. Our analyses provided significant evidence for gene-gene interactions in the development of AgP, in particular, present results: (a) indicate a possible role of two new polymorphisms, within SEPS1 and TNFRSF1B genes, in determining host individual susceptibility to AgP; (b) confirm the potential association between of IL-6 and Fc g-receptor polymorphisms and the disease; (c) exclude an essential contribution of IL-1 cluster gene polymorphisms to AgP in our Caucasian-Italian population.

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“…6 Interleukin (IL)-6 is a pleiotropic cytokine released by many cell types, and its secretion levels are determined by the producing cell type and the genetic background of the source cells. 8 Among several kinds of cytokines, IL-6 was found to be increased in gingival crevicular fluid (GCF) and gingival tissues of patients with periodontal disease. 9 A recent study reported that chronic periodontitis(CP) and generalized aggressive periodontitis (GAgP) patients had significantly higher GCF IL-6 levels in comparison with the healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

et al. 2017

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Cytokine gene polymorphisms in periodontal disease: a meta‐analysis of 53 studies including 4178 cases and 4590 controls

Cited by 159 publications

References 103 publications

Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis

Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters

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