Cytokine gene promoter polymorphisms and mortality in acute renal failure

Jaber, Bertrand L.; Madhumathi, R; Guo, Daoxia; Balakrishnan, Vaidyanathapuram S.; Perianayagam, Mary C.; Freeman, Richard B.; Pereira, Brian J.G.

doi:10.1016/j.cyto.2003.11.004

Cited by 106 publications

(79 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While a future, higher-powered study may find a role of APO E in AKI, current evidence is inadequate to make such a claim. Of the gene-gene interactions studied, the association between the TNF-␣ Ϫ308 AA and IL-10 Ϫ1082 AA/AG genotypes with dialysis or mortality demonstrated by Jaber et al is the most promising (16). While this association has yet to be replicated, the individual polymorphisms had small but significant associations with poor outcomes, and the combined gene-gene interaction was associated with a much higher risk than either polymorphism individually.…”

Section: Discussionmentioning

confidence: 92%

“…Jaber et al (16), in a study of 61 patients with AKI requiring hemodialysis, found that high producers of TNF-␣ (Ϫ308 A-allele carriers) possessed an increased risk of death after adjustment for APACHE II score (adjusted hazard ratio [HR] ϭ 2.5, P ϭ 0.04). However, three other studies searched for an association between this polymorphism and AKI incidence, but found none (11,15,17).…”

Section: Inflammatory and Anti-inflammatory Genesmentioning

confidence: 99%

“…No association was demonstrated between the Catalase gene and AKI. This study was unique in that it is one of two studies that examined associations with firm outcomes, i.e., dialysis or mortality (16,33).…”

Section: Oxidative Stress Genesmentioning

confidence: 99%

“…This has been seen in other complex diseases, such as the discovery of a single nucleotide polymorphism (SNP) in complement factor H as a risk factor for macular degeneration (13). In AKI, genetic variation in inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-␣) and Interleukin-6 (IL-6) have recently been proposed as risk factors (11,(14)(15)(16)(17). This is due to the role of inflammatory mediators in the pathophysiology of AKI, especially with ischemia and sepsis (1,18,19).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Searching for Genes That Matter in Acute Kidney Injury

Coca

Patel

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and Objectives: Identifying patients who may develop acute kidney injury (AKI) remains challenging, asclinical determinants explain only a portion of individual risk. Another factor that likely affects risk is intrinsic genetic variability. Therefore, a systematic review of studies was performed that related the development or prognosis of AKI to genetic variation.Design, setting, participants, and measurements: MEDLINE, EMBASE, HuGEnet, SCOPUS, and Web of Science were searched for articles from 1950 to Dec 2007. Two independent researchers screened articles using predetermined criteria. Studies were assessed for methodological quality via an aggregate scoring system. Results: The 16 included studies were of cohort or case-cohort design and investigated 35 polymorphisms in 21 genes in association with AKI. Fifteen gene-gene interactions were also investigated in four separate studies. Study populations were primarily premature infants or adults who were critically ill or postcardiac bypass patients. Among the studies, five different definitions of AKI were used. Only one polymorphism, APO E e2/e3/e4, had greater than one study showing a significant impact (P < 0.05) on AKI incidence. The mean quality score of 5.8/10 (range four to nine), heterogeneity in the studies, and the dearth of studies precluded additional meta-analysis of the results.Conclusions: Current association studies are unable to provide definitive evidence linking genetic variation to AKI. Future success will require a narrow consensus definition of AKI, rigorous epidemiologic techniques, and a shift from a priori hypothesis-driven to genome-wide association studies.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Inflammatory and Anti-inflammatory Genesmentioning

confidence: 99%

Section: Oxidative Stress Genesmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Searching for Genes That Matter in Acute Kidney Injury

Coca

Patel

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…In our study, individuals with the AA genotype of rs1800629 had a nonsignificant higher risk of AVF failure. This SNP has been the focus of several previous studies, focusing on a wide variety of endpoints, including cardiovascular events in rheumatoid arthritis patients (33), irritable bowel syndrome (34), life expectancy (35), tuberculosis susceptibly (36), mortality after ARF (37), and comorbidity and functional status scores in hemodialysis patients (38). The other analyzed SNP in the TNF gene (rs361525) was also not associated with AVF failure in our study, although it was previously associated with coronary restenosis (39).…”

Section: Discussionmentioning

confidence: 99%

Candidate Gene Analysis of Arteriovenous Fistula Failure in Hemodialysis Patients

Verschuren

Ocak²,

Dekker³

et al. 2013

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryBackground and objectives Arteriovenous fistula (AVF) failure remains an important cause of morbidity in hemodialysis patients. The exact underlying mechanisms responsible for AVF failure are unknown but processes like proliferation, inflammation, vascular remodeling, and thrombosis are thought to be involved. The current objective was to investigate the association between AVF failure and single nucleotide polymorphisms (SNPs) in genes related to these pathophysiologic processes in a large population of incident hemodialysis patients.Design, setting, participants, & measurements A total of 479 incident hemodialysis patients were included between January 1997 and April 2004. Follow-up lasted 2 years or until AVF failure, defined as surgery, percutaneous endovascular intervention, or abandonment of the vascular access. Forty-three SNPs in 26 genes, related to proliferation, inflammation, endothelial function, vascular remodeling, coagulation, and calcium/ phosphate metabolism, were genotyped. Relations were analyzed using Cox regression analysis.Results In total, 207 (43.2%) patients developed AVF failure. After adjustment, two SNPs were significantly associated with an increased risk of AVF failure. The hazard ratio (95% confidence interval) of LRP1 rs1466535 was 1.75 (1.15 to 2.66) and patients with factor V Leiden had a hazard ratio of 2.54 (1.41 to 4.56) to develop AVF failure. The other SNPs were not associated with AVF failure. ConclusionsIn this large cohort of hemodialysis patients, only 2 of the 43 candidate SNPs were associated with an increased risk of AVF failure. Whether other factors, like local hemodynamic circumstances, are more important or other SNPs play a role in AVF failure remains to be elucidated.

show abstract

Bicarbonate versus lactate solutions for acute haemodialysis

Tian

Liu

et al. 2007

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Cytokine gene promoter polymorphisms and mortality in acute renal failure

Cited by 106 publications

References 28 publications

Searching for Genes That Matter in Acute Kidney Injury

Searching for Genes That Matter in Acute Kidney Injury

Candidate Gene Analysis of Arteriovenous Fistula Failure in Hemodialysis Patients

Bicarbonate versus lactate solutions for acute haemodialysis

Contact Info

Product

Resources

About