Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Arora, Vivek; Verma, Jyotsna; Marwah, Vishal; Kumar, Ashok; Anand, Devyani; Das, Nibhriti

doi:10.1177/0961203311434937

Cited by 33 publications

(21 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly to our data, Tabarkiewicz et al 27 also showed that increased plasma IL‐17 concentrations were associated with severity in SLE patients. Finally, in accordance with others studies, we also found that increased levels of IL‐10 (a Treg cytokine) strongly predicted SLE and severity of the illness 20 , 28 . This cytokine may play a key role in the pathogenesis of SLE because IL‐10 enhances antibody secretion, regulates growth and differentiation of B‐cells and blunts T‐cell activation and TNF‐α secretion.…”

Section: Discussionsupporting

confidence: 91%

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles

et al. 2017

View full text Add to dashboard Cite

The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed. IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE. The Th1/Th2 and Th1+Th17/Th2 profiles were significantly higher in SLE than in healthy controls, whereas there were no significant differences in the proinflammatory cytokine profile (TNFα+IL-6+IL-1β). In total, 90.4% of all subjects were correctly classified using Th1+Th17 profile and IL-10 (positively associated) and IL-4 (negatively associated) as predictor variables (sensitivity=66.7% and specificity=96.9%). In all, 20.9% of the variance in the SLE Disease Activity Index was predicted by the Th1+Th17/Th2 ratio, IL-10 and BMI (all positively) and proinflammatory profile (inversely associated). B1/B1 genotype is accompanied by increased IL-17 and Th17/Th2 ratio, while B1/B2 genotype is accompanied by higher IL-4 and IFNγ values. 25-OH vitamin D was inversely associated with IFN-γ levels. SLE is accompanied by Th1, Th17 and Treg profile and lowered IL-4 production. Lowered vitamin D levels and B1/B1 genotype, but not BMI, contribute to changes in cytokines profiles. Future treatments should target Th1, Th2 and Th17 profiles rather than inflammatory cytokines.

show abstract

Section: Discussionsupporting

confidence: 91%

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Herein, the level of IL-4 was compared with the controls as reported in previous studies [20,27]. Also, it has been found that the percentage of IL-4+ cells within the CD4+T-cells from SLE patients is not statistically different in comparison to healthy controls [14].…”

Section: Discussionmentioning

confidence: 96%

“…Plasma levels of IL-10 were consistently reported to be increased in SLE [8,19,27,28]. It has been found to be over produced by the B cells and monocytes [29].…”

Section: Discussionmentioning

confidence: 97%

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

et al. 2015

View full text Add to dashboard Cite

“…However, in MRL/lpr mice, an increased expression of TNF was observed in the serum and in the kidney tissue (35). Human studies involving adult patients showed increased serum levels of TNF with (10,11) or without (36) association with disease activity. Another study presented high levels of TNF in patients with inactive disease, suggesting a protective effect of this cytokine in SLE (9).…”

Section: Discussionmentioning

confidence: 99%

Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study

Cavalcanti

Santos

Mesquita

et al. 2017

Braz J Med Biol Res

View full text Add to dashboard Cite

Childhood-onset systemic lupus erythematosus (cSLE) exhibits an aggressive clinical phenotype and severe complications. This could be due to a pro-inflammatory cytokine milieu. Therefore, we determined plasma levels of Th1 (IL-2, IFN-γ, TNF), Th2 (IL-4), Th17 (IL-17A, IL-6), and Treg (IL-10) cytokines in a cohort of cSLE patients and healthy controls, and we evaluated the association between these cytokines and disease activity. We conducted a cross-sectional study with 51 cSLE patients from two pediatric rheumatology services. Ten cSLE patients participated in a longitudinal follow-up study. Blood samples were collected from the same patient during active and inactive disease. Disease activity was evaluated according to SLE Disease Activity Index 2000 (SLEDAI-2K). Cytokines levels were measured by cytometric bead array technique. cSLE patients had higher IL-6 (P<0.001) and IL-10 (P<0.001) levels than healthy controls. Patients with active disease had higher IL-6 and IL-10 levels than patients with inactive disease (P=0.001 and P=0.014, respectively) and the control group (both P<0.001). IL-6 (P=0.022), IL-10 (P=0.013), and IL-17A (P=0.041) levels were significantly higher during active than inactive disease. Linear regression analysis revealed IL-6 (P=0.002, 95%CI=0.006-0.025) and IL-10 (P=0.01 95%CI=0.021-0.150) as independent factors for increased SLEDAI-2K. IL-6, IL-10, and IL-17A are candidate biomarkers for disease activity in cSLE patients. This is the first longitudinal study to support their pivotal role in the pathogenesis of the disease.

show abstract

Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects

Cited by 33 publications

References 59 publications

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles

Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study

Contact Info

Product

Resources

About