Cytokine-induced killer (CIK) cells in cancer immunotherapy: report of the international registry on CIK cells (IRCC)

Abstract

Due to their easy availability and potent antitumor activity, CIK cells emerged as a promising immunotherapy approach in oncology and may gain major importance on the prognosis of cancer.

Influence of autologous dendritic cells on cytokine-induced killer cell proliferation, cell phenotype and antitumor activity in vitro

“…CD3 + CD8 + T cells play an essential role in the immune response against cancers (30). CD3 + CD56 + T cells are a subset of type II NKT cells with non-major histo compatibility complex-restricted tumor-killing activity (20,31). Collectively, these findings revealed that DC-CIKs were more effective as antitumor agents than CIKs.…”

Immunotherapy of DC-CIK cells enhances the efficacy of chemotherapy for solid cancer: a meta-analysis of randomized controlled trials in Chinese patients

“…Fever (1), arrest of bone-marrow, gastrointestinal reactions, peripheral neurotoxicity DcRen2013B (Ren et al, 2013) Vomiting (1), diarrhea (1), hepatic complications (2) Neuritis (1), vomiting (9), diarrhea (12), hepatic complications (4) DcYuan2013L (Yuan et al, 2013) Anemia, skin petechiae, fatigue, oral pain, constipation, peripheral neuropathy Fever, anemia, skin petechiae, fatigue, oral pain, constipation, peripheral neuropathy DcNi2013B (Ni et al, 2013) None Fever (3) DcGao2014G (Gao et al, 2014) None Fever (9) None: no adverse effects and reporting standards, which will benefit patients on condition that there is more registration (Schmeel et al, 2014). Meta-analysis is an optimal choice to analyze dozens of clinical studies.…”

Cytokine-induced killer cell transplantation: an innovative adoptive therapy

“…There are now over 45 studies present in the database reported on 22 different tumor entities altogether enrolling around 3,000 patients. CIK cells have gained major strides as a promising immunotherapy platform in oncology (Schmeel et al, 2015).…”