"Cytokine-Induced Neurogenesis and Gut Microbiota in Alzheimer’s Disease"

Abstract

Alzheimer's Disease (AD) is a progressive neurodegenerative disease for which no curative treatment has yet been established. We applied cytokine-induced neurogenesis treatment to a 73-year-old female AD patient carrying APOE ε4/ε4 alleles to regenerate residual neuronal stem cells, resulting in the successful regeneration of the atrophied hippocampus, which was associated with improved cognitive functions and the resolution of electrophysiological abnormalities. We also investigated the gut microbiota to clarify the modifiers that influence the progression of AD. Microbiota analysis showed the specific dysbiosis signature of Mild Cognitive Impairment (MCI), but this patient had milder dysbiosis than other MCI patients, which may modify the progression of AD pathology.