1993
DOI: 10.1016/0896-6273(93)90225-g
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Cytokine-induced programmed death of cultured sympathetic neurons

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Cited by 101 publications
(44 citation statements)
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“…Thus, the decrease in pancreatic catecholamines may reflect cholinergic differentiation but could also be due to degeneration of sympathetic fibers. In support of the latter possibility, Kessler et al (25) reported that cultured sympathetic neurons exposed to high levels of LIF undergo apoptosis and that NGF can ameliorate this effect.…”
Section: Discussionmentioning
confidence: 71%
“…Thus, the decrease in pancreatic catecholamines may reflect cholinergic differentiation but could also be due to degeneration of sympathetic fibers. In support of the latter possibility, Kessler et al (25) reported that cultured sympathetic neurons exposed to high levels of LIF undergo apoptosis and that NGF can ameliorate this effect.…”
Section: Discussionmentioning
confidence: 71%
“…Bone morphogenetic proteins such as BMP4 can influence early developmental events by inducing apoptosis (Graham et al, 1994) and LIF can cause sympathetic neuron cell death in culture (Kessler et al, 1993). The prominent role of cytokines in inducing apoptosis is underscored by TNF and Fas receptors.…”
Section: Discussionmentioning
confidence: 99%
“…In several studies, NF-B activation has been shown to be either proapoptotic 13,[33][34][35] or antiapoptotic. 36 -41 Furthermore, a recent study of global cerebral ischemia found that transient activation of NF-B may be neuroprotective, while more persistent activation could be responsible for the induction of proteins that lead to neuronal cell death.…”
Section: Hickenbottom Et Al Nf-b Activation and Cell Death After Expementioning
confidence: 99%