Cytokine induction by a linear 1,3-glucan, curdlan-oligo, in mouse leukocytes in vitro

Abstract

Taken together, these results suggest that CRDO stimulated mouse leukocytes to induce the production of cytokines, and the mechanism of the effect of CRDO on leukocytes is different from that of SCG.

Fungal cell wall agents suppress the innate inflammatory cytokine responses of human peripheral blood mononuclear cells challenged with lipopolysaccharide in vitro

“…ZYM was a less potent cytokine inducer than curdlan, which was also the case in our experiments. Hida et al suggested that the difference in affinity for dectin-1 influenced the ability of these β-glucans to induce the production of cytokines [29]. They demonstrated that the branched glucan oligosaccharides were recognized by dectin-1 with higher affinity than the comparable linear glucan, which resulted in a greater production of cytokines.…”

An insight into anti-inflammatory effects of fungal beta-glucans

“…In bone marrow-derived dendritic cells, bglucan induced productions of TNF-a and IL-6. Taken together, these results suggested that b-glucan stimulated mouse leukocytes to induce the productions of cytokines (Hida et al, 2009). LPS-stimulated NO production in RAW 264.7 cells was reported to be an effective approach for evaluating the anti-inflammatory activity of b-glucan.…”

Gut microbiota, the pharmabiotics they produce and host health

“…β-Glucan is a water-soluble fibre found in cereals, as well as in yeast, bacteria, algae and mushrooms (145) . The EPS β-glucan has been reported to have many health promoting properties, including immunomodulatory effects (146)(147)(148)(149) , lowering serum cholesterol levels (145,150) , antiosteoporotic (151) , antitumourigenic, anticytotoxic and antimutagenic effects (152,153) . Furthermore, oat β-glucan has also been associated with the ability to modulate satiety, thus controlling appetite (154,155) .…”