“…In contrast, high levels of IL-8 have been detected during acute inflammatory reactions (Garner et al, 1994;Ono et al, 1995;Strickland et al, 1997;Zweiman et al, 1997); in chronic skin diseases such as psoriasis vulgaris (Gearing et al, 1990;Nickoloff et al, 1991;Anttila et al, 1992;Schrö der et al, 1992;Schulz et al, 1993;Gillitzer et al, 1991;Gillitzer et al, 1996), palmoplantar pustulosis (Anttila et al, 1992), and bullous pemphigoid (Schmidt, 1996); and in nonmelanoma and melanoma skin tumors (Hansen et al, 1991;Ciotti et al, 1995;Bornscheuer et al, 1996). However, the role of IL-8 in the pathogenesis of skin diseases has been difficult to elucidate because of the abundance of other cytokines that can induce IL-8 expression.…”