Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time

Weckmann, Markus; Thiele, Dominik; Liboschik, L.; Bahmer, Thomas; Pech, Martin; Dittrich, Anna-Maria; Fuchs, Oliver; Happle, Christine; Schaub, Bianca; Ricklefs, Isabell; Rabe, Klaus F.; Mutius, Erika von; Hansen, Gesine; König, Inke R.; Kopp, Matthias

doi:10.1111/cei.13550

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…Several reasons could account for the discrepancy in findings; for example, concomitant diseases in the participants could partially explain formerly reported higher cytokine levels. Bronchial asthma is associated with heightened cytokine levels 19 ; analogously, these patients had higher cytokine levels in our study. Therefore, these conditions must be considered when interpreting cytokine levels in general.…”

Section: Discussionsupporting

confidence: 82%

Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19

Fleischer,

Szepanowski,

Mausberg

et al. 2024

Ther Adv Neurol Disord

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Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge. Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words. Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 ( n = 13), infected but had no PASC ( n = 34), infected with former PASC that resolved ( n = 40) and patients with ongoing PASC after infection ( n = 91). Methods: Cytokine and cortisol serum levels were determined in patients’ blood samples. Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed. Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.

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Section: Discussionsupporting

confidence: 82%

Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19

Fleischer,

Szepanowski,

Mausberg

et al. 2024

Ther Adv Neurol Disord

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“…Seasonal variations of serum TNF-α were reported in conditions with seasonal variability, though not for healthy individuals. The highest TNF-α values were observed during summer-fall, and the lowest from January to spring ( Spath et al, 2017 ; Weckmann et al, 2021 ). This pattern is contrary to our findings, suggesting that seasonal variations may not have influenced the results.…”

Section: Discussionmentioning

confidence: 99%

Urinary TNF-α as a potential biomarker for chronic primary low back pain

Gevers-Montoro,

Puente-Tobares,

Monréal

et al. 2023

Front. Integr. Neurosci.

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IntroductionOver two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic low back pain and who will recover from an acute episode. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated with poor recovery and persistent pain following an acute episode of LBP. Inflammatory cytokines may also mediate mechanisms involved in nociplastic pain, and thus, have significant implications in chronic primary low back pain (CPLBP).MethodsThis study aimed to investigate the potential of urinary TNF-α levels for predicting outcomes and characterizing clinical features of CPLBP patients. Twenty-four patients with CPLBP and 24 sex- and age-matched asymptomatic controls were recruited. Urinary TNF-α concentrations were measured at baseline and after 4 weeks, during which CPLBP patients underwent spinal manipulative therapy (SMT).ResultsConcentrations of TNF-α were found to be elevated in baseline urine samples of CPLBP patients compared to asymptomatic controls. Moreover, these values differed among patients depending on their pain trajectory. Patients with persistent pain showed higher levels of TNF-α, when compared to those with episodic CPLBP. Furthermore, baseline TNF-α concentrations and their changes after 4 weeks predicted alterations in pain intensity and disability following SMT in patients with CPLBP.DiscussionThese findings warrant further research on the potential use of urinary TNF-α concentrations as a prognostic biomarker for CPLBP.

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“…Furthermore, in this study we continuously recruited over several years as compared to a single season in our previous study. As it is known that cytokine levels differ significantly in between seasons this might influence comparability ( Weckmann et al, 2021 ). Another limitation is that despite the elevated levels of Th1 cytokines, we did not investigate severe childhood asthmatics.…”

Section: Discussionmentioning

confidence: 99%

In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

et al. 2022

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Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocytes (NGs) from asthmatics exhibit decreased chemotaxis towards leukotriene B4 (LTB4), a chemoattractant involved in inflammation response. We hypothesized that this pattern is driven by asthma in general and aggravated in a Th1-high phenotype.Methods: NGs from asthmatic nd healthy children were stimulated with 10 nM LTB4/100 nM N-formylmethionine-leucyl-phenylalanine and neutrophil migration was documented following our prior SiMA (simplified migration assay) workflow, capturing morphologic and dynamic parameters from single-cell tracking in the images. Demographic, clinical and serum cytokine data were determined in the ALLIANCE cohort.Results: A reduced chemotactic response towards LTB4 was confirmed in asthmatic donors regardless of inhaled corticosteroid (ICS) treatment. By contrast, only NGs from ICS-treated asthmatic children migrate similarly to controls with the exception of Th1-high donors, whose NGs presented a reduced and less directed migration towards the chemokines. ICS-treated and Th1-high asthmatic donors present an altered surface receptor profile, which partly correlates with migration.Conclusions: Neutrophil migration in vitro may be affected by ICS-therapy or a Th1-high phenotype. This may be explained by alteration of receptor expression and could be used as a tool to monitor asthma treatment.

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Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time

Cited by 6 publications

References 42 publications

Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19

Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19

Urinary TNF-α as a potential biomarker for chronic primary low back pain

In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

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