Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy

Costa, Fernando Oliveira; Cortelli, Sheila Cavalca; Silva, Tarcı́lia Aparecida; Costa, Amanda Almeida; Lima, Rafael Paschoal Esteves; Cortelli, José Roberto; Cota, Luís Otávio Miranda

doi:10.1007/s00784-018-2770-x

Cited by 14 publications

(15 citation statements)

References 47 publications

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“…This line of evidence is fundamental to identifying the effects of dysbiosis on mucosal inflammation throughout the digestive tract. Significantly higher levels of IL1β , IL6, IL8, and IL10 were found in constipated subjects with gingival bleeding from this study ( Figure 5), indicating an ongoing inflammatory process and the progression of periodontal disease [36][37][38][39][40]. Since the use of these medications cause CP subjects to present a reduced salivary flow rate, an increased value of salivary osmolality, dry mouth and gingivitis, which is represented by higher levels of inflammatory cytokines in quadriplegics [17].…”

Section: Discussionmentioning

confidence: 59%

“…IL-10 acts as an anti-inflammatory cytokine, inhibiting proinflammatory cytokines IL-1 and IL-6 associated with improvements in periodontal clinical parameters [57]. However, the degree of mucosal inflammation of constipated CP subjects represented by gingival bleeding was so high that IL-10 action did not reduce inflammatory process of dysbiosis [40]. Only one study reported the effect of mechanical treatment on gingivitis control measures by cytokines levels, and the results showed that, although occurs reduction of inflammatory process, the levels of IL-1β, I6 and IL-8 remain high compared to subjects without CP [8].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Inflammatory Factors Influencing Constipation and Quality of Life in Cerebral Palsy

Acf

Freire

et al. 2019

Preprint

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Introduction: Intestinal constipation is a clinical consequence, secondary to neuromotor disturbances, which acts on subjects with cerebral palsy (CP). The aim of this study was to investigate the factors influencing constipation and the quality of life (QOL) of CP subjects. Materials and methods: We recruited a total of 63 subjects aging from 5-17 years with spastic CP who received physical rehabilitation. The subjects were divided into two groups including with and without constipation. Subjects were assigned into one of the 4 groups (G1-4) based on the prevalence of 1) CP and 2) Constipation. Subjects were assigned as CP with constipation (G1), CP without constipation (G2), and controls without CP with constipation (G3) and without CP and without constipation (G4). Subject demographics, use of antiepileptic drugs (AEDs), motor function, caregiver priorities and child health index of life with disabilities (CPCHILD) were included. In addition to medical metadata, a subset of subjects was evaluated for oral and systemic inflammation through gingival bleeding and serum cytokine levels (TNF-alpha, IL-1 beta, IL-6, IL-8, IL-10) respectively. Statistical significance was evaluated by ANOVA One-Way (parametric data) and Kruskal Wallis (non-parametric data). Results: A significant relationship was found between the type of medication and constipation. Subjects taking GABA and GABA+ (GABA in association with other medication) were more likely to be constipated than the other groups (P < 0.01). Additionally, quality of life was directly correlated with constipation; subjects in G1 presented the lower mean score of CPCHILD (49.0 SD13.1) compared to G2 (71.5 SD 16.7) when compared to G3 (88.9 SD 7.5), and G4 (95.5 SD5.0) (P < 0.01). Inflammation was more severe for patients in G1 (P < 0.001). There were no differences among groups regarding gender (P = 0.332) and age (P = 0.292). Conclusions: Our results suggest that constipation was mostly affected by the use of certain antiepileptic drugs, namely GABA. This showed a direct detrimental effect on CP quality of life, which was influenced by inflammatory cytokines and the dosage and type of AEDs.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Clinical and Inflammatory Factors Influencing Constipation and Quality of Life in Cerebral Palsy

Acf

Freire

et al. 2019

Preprint

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“…Diversas citocinas são produzidas no processo da doença periodontal, e as mais frequentemente encontradas são: IL-1, IL-6, IL-8 e TNF-α. Todas estas citocinas desempenham um papel fundamental nas respostas imunes e inflamatória, e o resultado da infecção, susceptibilidade e extensão, podem ser atribuído ao equilíbrio na taxa relativa entre todos eles, sendo de suma importância para o desencadeamento e perpetuação das periodontites (Nicolau, Rapoport & Selski, 2003;Franco et al, 2015;Costa et al, 2019). Os perfis de citocinas são de considerável valor ao estudar a destruição do tecido periodontal, pois estas não permanecem exclusivamente no interior da bolsa periodontal, mas atingem a corrente sanguínea, justificando as relações entre doença periodontal e alterações sistêmicas, podendo induzir ou perpetuar os efeitos sistêmicos, sendo o exemplo mais conhecido o risco de desenvolvimento de endocardite bacteriana após procedimentos cirúrgicos bucais em pacientes com algumas alterações cardíacas (Gowen, et al, 1983;McCauley & Nohutcu, 2002;Lima et al, 2008).…”

Section: Resultsunclassified

“…Tanto a gengivite quanto a periodontite possuem como fator etiológico a placa bacteriana (Honda et al, 2006;Junior, Nomura, & Politano, 2007;Gupta et al, 2018;Costa et al, 2019) que pode ser definida como uma película não calcificada fortemente aderida às superfícies dentais, resistindo à presença do fluxo salivar, composta por bactérias grampositivas (Actinomyces viscosus e Streptococcus sanguis) dispostas sob a forma de biofilmes microbianos que se aderem à película através de adesinas e interagem com receptores específicos na película dental possibilitando a retenção de substâncias produzidas pela própria bactéria e protegendo-as de fatores de defesa do organismo hospedeiro e agentes antimicrobianos externos. O crescente acúmulo de microrganismos no biofilme dental em íntima proximidade aos tecidos periodontais faz com que ocorra alterações no microambiente Research, Society and Development, v. 9, n. 7, e674974773, 2020 (CC BY 4. (Gomes et al, 2016;Budneli, 2019).…”

Section: Introductionunclassified

O papel da interleucina-1beta na fisiopatogenia da doença periodontal: uma revisão de literatura

Fróes

Pasquinelli

Quintela

et al. 2020

RSD

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The bacteria involved in the gingival inflammatory process induce inflammatory responses characterized by the release of mediators, for example, interleukins, the cytokines involved in the course of development of periodontal disease are not yet fully established. The increase in the amount of interleukin-1beta (IL-1β) is correlated, in the periodontal lesion, with the progression from the stable lesion to the progressive lesion. The purpose of this literature review was to evaluate IL-1β and its influence on the development of periodontal disease. Initially, 860 articles from the following databases were evaluated in this literature review: Pubmed, Lilacs, Scielo, Web of Science, Embase and Cochrane. The search terms were: periodontal disease and IL-1β; periodontitis and IL-1β; oral health and IL-1β; gingivitis and IL-1β. With the adopted criteria, 28 articles were included in this literature review. The observed results showed that IL-1β is the one that most relates to the activity of the disease, since patients with periodontitis have a higher frequency of a genotype associated with increased production. These cytokines can be generated by immune cells, such as lymphocytes and monocytes in the medullary cavity or by other bone cells, particularly cells of the osteoblastic lineage. We conclude that IL-1β is directly related to the progression of periodontal disease, promoting the entry of inflammatory cells to the sites of infection and high levels of IL-1β are related to bleeding rates, probing depth and clinical level of insertion changed.

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“…Por el contrario, otras investigaciones realizadas por Konopka et al 28 y Costa et al 29 observaron que la terapia no quirúrgica a corto plazo mejoró de forma significativa los índices periodontales y disminuyó los niveles en fluido gingival crevicular de la IL-1β, IL-8 y MMP-8.…”

Section: Discussionunclassified

Evaluación de los mediadores IL-1α, IL-1β y TNF-α, en fluido gingival crevicular de pacientes con periodontitis

Simone

Escalona

Ávila

et al. 2019

Odontol. sanmarquina

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Objetivo. Evaluar los niveles de mediadores químicos inflamatorios como la interleucina- 1α (IL-1α), interleucina-1β (IL-1β), factor de necrosis tumoral-α (TNF-α) y los parámetros clínicos en pacientes diagnosticados con periodontitis crónica o agresiva, antes y después de la terapia periodontal no quirúrgica (TPNQ). Métodos. Se tomaron muestras de fluido gingival crevicular (FGC) en 11 pacientes diagnosticados con periodontitis y 11 controles sanos para evaluar niveles de IL-1α, IL-1β, TNF-α antes y después de la TPNQ, mediante la técnica de ELISA (Enzyme-Linked Immuno Sorbent Assay). Resultados. En el grupo con periodontitis se observó disminución significativa de los parámetros clínicos después del tratamiento (p<0,05). En FGC, IL-1β presentó los niveles más elevados, seguido de IL-1α y TNF-α. Posterior a la TPNQ, IL-1β disminuyó 17 veces su concentración e IL-1α 4 veces en relación a los valores iniciales, sin embargo, solo se observó una relación estadísticamente significativa para TNF-α. Las mayores correlaciones con los parámetros clínicos de la enfermedad periodontal se observaron para IL-1β (p<0,01), seguido por IL-1α (p<0,05) y una baja correlación con TNF-α. Conclusiones. En este trabajo, el grupo de pacientes con periodontitis presentó mayores niveles de IL-1α, IL-1β y TNF-α en FGC, siendo IL-1β la citocina más elevada. Posterior al TPNQ, se observó disminución significativa de los valores clínicos periodontales. Así mismo, las interleucinas redujeron sus valores promedios, sin alcanzar los del grupo control. Las correlaciones observadas entre los índices periodontales y los mediadores sugieren mayor correlación de IL-1β con los signos clínicos de la enfermedad periodontal.

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Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy

Cited by 14 publications

References 47 publications

Clinical and Inflammatory Factors Influencing Constipation and Quality of Life in Cerebral Palsy

Clinical and Inflammatory Factors Influencing Constipation and Quality of Life in Cerebral Palsy

O papel da interleucina-1beta na fisiopatogenia da doença periodontal: uma revisão de literatura

Evaluación de los mediadores IL-1α, IL-1β y TNF-α, en fluido gingival crevicular de pacientes con periodontitis

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