Cytokine levels in Crimean-Congo hemorrhagic fever

Papa, Anna; Bino, Silva; Velo, Enkelejda; Harxhi, Arjan; Kota, Majlinda; Ántoniadis, Antonis

doi:10.1016/j.jcv.2006.04.007

Cited by 138 publications

(126 citation statements)

References 18 publications

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“…In a very recent study, Papa et al [23] from Greece also reported similar findings regarding cytokine storm in Albanian patient seen in the outbreak of 2003. In the study population, statistically significant differences between the groups were obtained for TNF-a and IL-6 [23]. These findings also support the distinctive role of cytokine storm in the pathophysiology of the infection, and TH1 response and lack of viral clearance are shown to be the key factors of the pathophysiology resulting the cytokine storm in primary and some sHPS including macrophage activating syndrome (MAS) in systemic Juvenile rheumatoid arthritis.…”

Section: Discussionsupporting

confidence: 62%

“…However, levels of IL-10 were not significantly different between these two groups [3]. In a very recent study, Papa et al [23] from Greece also reported similar findings regarding cytokine storm in Albanian patient seen in the outbreak of 2003. In the study population, statistically significant differences between the groups were obtained for TNF-a and IL-6 [23].…”

Section: Discussionsupporting

confidence: 53%

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Crimean‐Congo hemorrhagic fever: Five patients with hemophagocytic syndrome

Fışgın

Tanyel

et al. 2007

American J Hematol

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Three pediatric and two adult Turkish patients with Crimean Congo Hemorrhagic Fever (CCHF) induced hemophagocytic syndrome (HPS) were admitted to Ondokuz Mayis University Hospital, which is in the Middle Black Sea Region of Turkey. All of them had remarkable hemophagocytosis in the bone marrow with severe bleeding symptoms along with the other known clinical and laboratory findings of CCHF. We would like to present these patients and to discuss the pathophysiology and the effect of acquired HPS on the severity of the disease. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 53%

Crimean‐Congo hemorrhagic fever: Five patients with hemophagocytic syndrome

Fışgın

Tanyel

et al. 2007

American J Hematol

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“…These cytokines were also implicated as a marker of CCHF disease severity in patients (16,28,29,33). We could not detect any TNF-␣ or IL-1␤ in supernatants collected from CCHFV-infected endothelial cells.…”

Section: Fig 2 Activation Of Endothelial Cells Is Virus Dose Dependmentioning

confidence: 99%

“…on April 8, 2019 by guest http://jvi.asm.org/ CCHF disease severity (16,28). Conditioned medium from CCHFV-infected (MOI, 10) or noninfected moDCs harvested at 48 h p.i.…”

Section: Vol 85 2011 Cchfv Activates Endothelial Cells 7769mentioning

confidence: 99%

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Crimean-Congo Hemorrhagic Fever Virus Activates Endothelial Cells

Connolly‐Andersen

Moll

Andersson

et al. 2011

J Virol

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Crimean-Congo hemorrhagic fever virus (CCHFV) causes viral hemorrhagic fever with high case-fatality rates and is geographically widely distributed. Due to the requirement for a biosafety level 4 (BSL-4) laboratory and the lack of an animal model, knowledge of the viral pathogenesis is limited. Crimean-Congo hemorrhagic fever (CCHF) is characterized by hemorrhage and vascular permeability, indicating the involvement of endothelial cells (ECs). The interplay between ECs and CCHFV is therefore important for understanding the pathogenesis of CCHF. In a previous study, we found that CCHFV-infected monocyte-derived dendritic cells (moDCs) activated ECs; however, the direct effect of CCHFV on ECs was not investigated. Here, we report that ECs are activated upon infection, as demonstrated by upregulation of mRNA levels for E-selectin, vascular cell adhesion molecule 1 (VCAM1), and intercellular adhesion molecule 1 (ICAM1). Protein levels and cell surface expression of ICAM1 responded in a dose-dependent manner to increasing CCHFV titers with concomitant increase in leukocyte adhesion. Furthermore, we examined vascular endothelial (VE) cadherin in CCHFVinfected ECs by different approaches. Infected ECs released higher levels of interleukin 6 (IL-6) and IL-8; however, stimulation of resting ECs with supernatants derived from infected ECs did not result in increased ICAM1 expression. Interestingly, the moDC-mediated activation of ECs was abrogated by addition of neutralizing tumor necrosis factor alpha (TNF-␣) antibody to moDC supernatants, thereby identifying this soluble mediator as the key cytokine causing EC activation. We conclude that CCHFV can exert both direct and indirect effects on ECs.

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Bunyaviridae

Taylor¹,

Altamura²,

Schmaljohn³

2009

Encyclopedia of Life Sciences

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The family Bunyaviridae is a large and diverse group of enveloped viruses with ribonucleic acid (RNA) genomes. The family consists of over 300 species that are divided into 5 genera. All bunyavirus genomes are comprised of three negative‐sense RNA segments, but they differ in their coding strategies to generate the structural and nonstructural proteins required for replication. Viruses are transmitted by infected vectors that include mosquitoes, phlebotomine flies, ticks and rodents. Bunyaviruses are distributed worldwide and are responsible for a variety of illnesses in human hosts ranging from mild to haemorrhagic fevers or fatal encephalitis. Thus, bunyaviruses are important infectious agents and vector control, precautionary measures, and education are needed to prevent future outbreaks in endemic areas. Key Concepts Bunyavirus replication occurs in the cytoplasm via a viral RNA‐dependent RNA polymerase. All bunyavirus genomes consist of three negative‐sense RNA segments that encode for structural and/or nonstructural proteins. Structural proteins are required for replication and nonstructural proteins generally play a role in evading host cellular responses. Vectors that transmit bunyaviruses to humans include mosquitoes, phelobotomine flies, ticks and rodents. Symptoms of bunyavirus infection include mild febrile illness, haemorrhagic fever and encephalitis. Bunyaviruses can be found worldwide, so precautionary measures should be taken when travelling to endemic areas.

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Cytokine levels in Crimean-Congo hemorrhagic fever

Cited by 138 publications

References 18 publications

Crimean‐Congo hemorrhagic fever: Five patients with hemophagocytic syndrome

Crimean‐Congo hemorrhagic fever: Five patients with hemophagocytic syndrome

Crimean-Congo Hemorrhagic Fever Virus Activates Endothelial Cells

Bunyaviridae

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