Cytokine Levels in Neural Pain in Leprosy

Dbm, Angst; Ro, Pinheiro; Jsds, Vieira; Cobas, Roberta Arnoldi; Mav, Hacker; Ijr, Pitta; Lm, Giesel; En, Sarno; Mr, Jardim

doi:10.3389/fimmu.2020.00023

Cited by 22 publications

(28 citation statements)

References 62 publications

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“…Backryd et al have also demonstrated that patients with neuropathic pain have a higher level of IL-6 ( 30 ). A study by Angst et al has also been reported that increased IL-6 concentration was noted in the patients with painful DPN ( 31 ).Data also show that IL-6 is a proinflammatory cytokine that has a significant effect on glial cells and neurons and trigger the onset of DPN in motion ( 32 ). Ma et al have performed SC144 to block the IL-6-mediated signal transduction and demonstrate the function of IL-6 in the mechanical hyperalgesia induced by DM.…”

Section: Discussionmentioning

confidence: 91%

“…Spearman correlations of serum vitamin D levels with clinical and biochemical parameters.Backryd et al have also demonstrated that patients with neuropathic pain have a higher level of IL-6(30). A study by Angst et al has also been reported that increased IL-6 concentration was noted in the patients with painful DPN(31).Data also show that IL-6 is a proinflammatory cytokine that has a significant effect on glial cells and neurons and trigger the onset of DPN in motion(32).…”

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confidence: 91%

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Severe Vitamin D Deficiency Is Associated With Increased Expression of Inflammatory Cytokines in Painful Diabetic Peripheral Neuropathy

et al. 2021

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Background: The exact pathogenic mechanism of the painful diabetic peripheral neuropathy (DPN) is poorly understood. Our study aimed to evaluate the association amongst vitamin D status, inflammatory cytokines, and painful DPN.Methods: A total of 483 patients were divided into three groups, i.e., diabetes without DPN (no-DPN, n = 86), diabetes with painless DPN (painless DPN, n = 176) and diabetes with painful DPN (painful DPN, n = 221) groups. Basic information and laboratory results were collected. The concentrations of vitamin D (25-hydroxyvitamin D), high-sensitivity C-reactive protein, interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were also measured.Results: The prevalence of severe vitamin D deficiency (<10 ng/mL) was more common in the painful DPN group than in the painless DPN and no-DPN groups (25.8,12.5, and 8.1%, respectively, P < 0.01). Cases in the painful DPN group had significantly higher concentrations of IL-6 (P < 0.01) and TNF-α (P < 0.01) than those in the two other groups. The multivariate logistic analysis showed that severe vitamin D deficiency, IL-6, and TNF-α were independent risks for painful DPN after adjusting for confounding factors. Furthermore, the vitamin D status had significantly negative correlations with IL-6 (r = −0.56, P < 0.01) and TNF-α (r = −0.47, P < 0.01) levels.Conclusion: Severe vitamin D deficiency was an independent risk factor for the painful DPN. Severe vitamin D deficiency status may play a role in the painful DPN pathogenesis through elevated IL-6 and TNF-α levels.

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Section: Discussionmentioning

confidence: 91%

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confidence: 91%

Severe Vitamin D Deficiency Is Associated With Increased Expression of Inflammatory Cytokines in Painful Diabetic Peripheral Neuropathy

et al. 2021

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“…Níveis aumentados de TNFα, TGF-β e IL-17 em pacientes com hanseníase e dor neural também foram detectados. Um estudo demonstrou que, na hanseníase, o TNFα e o TGF-β induzem apoptose nas células de Schwann, com consequente dano ao nervo periférico (Angst et al, 2020).…”

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Lesão neural hansênica: Papel da neurotrofina NGF e da citocina TNFα

Carneiro

Souza

Silva

et al. 2021

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Os mecanismos imunopatológicos envolvidos no desenvolvimento de lesão neural hansênica ainda não são completamente esclarecidos. Sendo assim, o objetivo deste trabalho foi realizar uma revisão integrativa a fim de identificar o envolvimento da neurotrofina NGF e da citocina TNFα na patogênese da lesão neural hansênica. Esta revisão foi realizada mediante a busca de artigos nas plataformas indexadoras PubMed, SciELO e Google Acadêmico com os Descritores em Ciências da Saúde (DeCS) “Leprosy Reaction”, “Nerve Growth Factor (NGF)”, “Tumor Necrosis Factor- alpha (TNFα)”, sendo selecionados 28 artigos. Os resultados evidenciaram que durante a reação do tipo 1 há expressão tecidual de IL-2, IFN-g, TNFα, IL-12 e IL-1b. Já a reação do tipo 2 ou ENH tem sido associada com altas concentrações de TNFα, infiltração neutrofílica e ativação do sistema complemento. Altos níveis de NGF foram observados na forma lepromatosa e baixos níveis na forma tuberculoide da doença, pois nesta há estímulo da expressão de TNFα o que contribui para a evolução de lesões neurais. Parece haver uma interação entre NGF e TNFα, uma vez que o NGF induz a expressão endógena de TNFα e esse feedback positivo promove uma sobrevida das células neurais saudáveis.

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“…Il-1β is produced and secreted by immune cells such as macrophages, microglia, and monocytes; and is secreted under conditions of stress. 22 An increase in the concentration of IL-1β has been implicated in various diseases which include neuropathic pain due to diabetes, rheumatoid arthritis, type 2 diabetes, inflammatory bowel disease, leprosy neuropathy, and other inflammatory diseases. 22,23 It was observed from our studies that the concentration of IL-1β was © 2020 the authors.…”

Section: Effect Of Aqueous and Butanol Leaf Fractions Of Olax Subscormentioning

confidence: 99%

“…22 An increase in the concentration of IL-1β has been implicated in various diseases which include neuropathic pain due to diabetes, rheumatoid arthritis, type 2 diabetes, inflammatory bowel disease, leprosy neuropathy, and other inflammatory diseases. 22,23 It was observed from our studies that the concentration of IL-1β was © 2020 the authors. This work is licensed under the Creative Commons Attribution 4.0 International License increased in the fractions treated groups; the observed increase may be due to direct stimulation of IL-1 receptor antagonist (IL-1ra) by the fractions or indirectly via the IL-6 (and/or other anti-inflammatory cytokines).…”

Section: Effect Of Aqueous and Butanol Leaf Fractions Of Olax Subscormentioning

confidence: 99%

Effects of Aqueous and Butanol Leaf Fractions of Olax subscorpioidea Oliv. on Inflammatory Cytokines in Wistar Rats

2020

TJNPR

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Inflammation is regarded as the primary physiologic defense mechanism that helps protect the body against allergens, infection, toxic chemicals, burns, or other noxious stimuli. 1 It has been demonstrated as the root cause of almost all chronic diseases, such as cardiovascular diseases, cancer, inflammatory bowel syndrome, atherosclerosis, arthritis, and autoimmune diseases. 2,3 Likewise, inflammatory and oxidative processes have been implicated in the pathological features associated with the central nervous system in Alzheimer's disease. 4 Inflammation is caused by a variety of soluble factors; which include lipoxins, platelet activating factor (PAF), leukotrienes, prostaglandins, and cytokines. 5 Cytokines are the major determinants of the systemic responses to inflammation. 5 They are small proteins that are secreted and released by cells and they have a specific effect on the communications and interactions between cells. 6 They are divided into

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Cytokine Levels in Neural Pain in Leprosy

Cited by 22 publications

References 62 publications

Severe Vitamin D Deficiency Is Associated With Increased Expression of Inflammatory Cytokines in Painful Diabetic Peripheral Neuropathy

Severe Vitamin D Deficiency Is Associated With Increased Expression of Inflammatory Cytokines in Painful Diabetic Peripheral Neuropathy

Lesão neural hansênica: Papel da neurotrofina NGF e da citocina TNFα

Effects of Aqueous and Butanol Leaf Fractions of Olax subscorpioidea Oliv. on Inflammatory Cytokines in Wistar Rats

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