2013
DOI: 10.1016/j.bbadis.2012.09.014
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Cytokine mediated tissue fibrosis

Abstract: Acute inflammation is a recognised part of normal wound healing. However, when inflammation fails to resolve and a chronic inflammatory response is established this process can become dysregulated resulting in pathological wound repair, accumulation of permanent fibrotic scar tissue at the site of injury and the failure to return the tissue to normal function. Fibrosis can affect any organ including the lung, skin, heart, kidney and liver and it is estimated that 45% of deaths in the western world can now be a… Show more

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Cited by 326 publications
(297 citation statements)
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References 273 publications
(221 reference statements)
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“…Fibrosis refers to the laying down of pathological variants of a variety of proteins in an insoluble form, 500 and also occurs in response to inflammation. Although we are concentrating here on events in blood, it is not a coincidence that 'fibrosis' shares the same etymological root as fibrin(oge)n. Most pertinently, fibrosis can be seen under the same hypercoagulable conditions as discussed here, [501][502][503][504][505][506] and may be considered to have a common cause (and, potentially, cure).…”
Section: Relationship Between Inflammation and Fibrosismentioning
confidence: 99%
“…Fibrosis refers to the laying down of pathological variants of a variety of proteins in an insoluble form, 500 and also occurs in response to inflammation. Although we are concentrating here on events in blood, it is not a coincidence that 'fibrosis' shares the same etymological root as fibrin(oge)n. Most pertinently, fibrosis can be seen under the same hypercoagulable conditions as discussed here, [501][502][503][504][505][506] and may be considered to have a common cause (and, potentially, cure).…”
Section: Relationship Between Inflammation and Fibrosismentioning
confidence: 99%
“…Previous studies showed that CTGF promotes inflammatory response [21]. Chronic inflammatory response can result in pathological wound repair and the accumulation of permanent fibrotic scar tissue at the site of injury and this fibrosis may lead to a decrease in organ function and, in some cases, organ failure and death [22]. Summarily, another possible hypothesis could be given that the TGF-β1/CTGF pathway may also be involved in the CNP.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies showed that CTGF promotes inflammatory response [26]. Chronic inflammatory response can result in pathological wound repair and the accumulation of permanent fibrotic scar tissue at the site of injury and this fibrosis may lead to a decrease in organ function and, in some cases, organ failure and death [27]. Summarily, another possible hypothesis could be given that the TGF-β1/CTGF pathway may also be involved in the CNP.…”
Section: Discussionmentioning
confidence: 99%