Cytokine Milieu in Infectious Disease: A Sword or a Boon?

Soni, Bhavnita; Singh, Shailza

doi:10.1089/jir.2019.0089

Cited by 5 publications

(5 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once the human cells are infected, cytokines can kill pathogens by stimulating the human immune system, clear the damaged cells, and repair the damaged tissues. [ 5 ] In most circumstances, cytokines can defect the aggravations of pathogens and protect our health system. [ 6 ] However, when the balance is broken, the fatal cytokine storm will occur.…”

Section: Introductionmentioning

confidence: 99%

Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T_x MXene

et al. 2021

View full text Add to dashboard Cite

During the global outbreak of COVID‐19 pandemic, “cytokine storm” conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D Ti3C2Tx MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin‐6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular‐level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin‐6 molecules, which is different from activated carbon absorbents. MXene sheet also demonstrates excellent blood compatibility without any deleterious side influence on the composition of human blood. This work can open a new avenue to use MXene sheets as an ultraefficient hemoperfusion absorbent to eliminate the cytokine storm syndrome in treatment of severe COVID‐19 patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T_x MXene

et al. 2021

View full text Add to dashboard Cite

show abstract

“…They are usually produced by different cell types in response to bacterial products and other pathogens. Besides the promotion of immune cells chemotaxis to the site of infection, they regulate a variety of biological processes related to cellular activation, differentiation and survival 61 , such as those found in our study (Supplementary File 1: Table S3). In mice, it has been shown that in the presence of bacterial infection, there is an increase of inflammatory cytokines, which can lead to osteocyte apoptosis and consequently osteonecrosis 62 63 , while CCR5 has already been identified as biomarker for osteonecrosis of the femoral head in human plasma 64 .…”

Section: Discussionmentioning

confidence: 53%

Differentially expressed genes in the femur cartilage transcriptome clarify the understanding of femoral head separation in chickens

Hul

Ibelli

Savoldi

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Locomotor problems are among one of the main concerns in the current poultry industry, causing major economic losses and affecting animal welfare. The most common bone anomalies in the femur are dyschondroplasia, femoral head separation (FHS), and bacterial chondronecrosis with osteomyelitis (BCO), also known as femoral head necrosis (FHN). The present study aimed to identify differentially expressed (DE) genes in the articular cartilage (AC) of normal and FHS-affected broilers by RNA-Seq analysis. In the transcriptome analysis, 12,169 genes were expressed in the femur AC. Of those, 107 genes were DE (FDR < 0.05) between normal and affected chickens, of which 9 were downregulated and 98 were upregulated in the affected broilers. In the gene-set enrichment analysis using the DE genes, 79 biological processes (BP) were identified and were grouped into 12 superclusters. The main BP found were involved in the response to biotic stimulus, gas transport, cellular activation, carbohydrate-derived catabolism, multi-organism regulation, immune system, muscle contraction, multi-organism process, cytolysis, leukocytes and cell adhesion. In this study, the first transcriptome analysis of the broilers femur articular cartilage was performed, and a set of candidate genes (AvBD1, AvBD2, ANK1, EPX, ADA, RHAG) that could trigger changes in the broiler´s femoral growth plate was identified. Moreover, these results could be helpful to better understand FHN in chickens and possibly in humans.

show abstract

“…The activation of innate and adaptive immune cells and the strength of initiated immune responses rely on cytokine and chemokine milieus [ 55 , 56 ]. Using the Mouse Anti-Virus Response Panel (13-plex, Legendplex TM ; BioLegend, San Diego, CA, USA), soluble cytokines and chemokines were analyzed in plasma samples at 6 h, 10 d and 21 d after the first injection ( Figure S6 ).…”

Section: Resultsmentioning

confidence: 99%

Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice

Weissfuss

Wienhold

Bürkle

et al. 2023

Viruses

View full text Add to dashboard Cite

Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern. In this study, we investigated the innate and adaptive immune responses to two different phage cocktails targeting either Pseudomonas aeruginosa or Escherichia coli—two VAP-associated pathogens—in naïve mice without the confounding effects of a bacterial infection. Active or UV-inactivated phage cocktails or buffers were injected intraperitoneally daily for 7 days in C57BL/6J wild-type mice. Blood cell analysis, flow cytometry analysis, assessment of phage distribution and histopathological analysis of spleens were performed at 6 h, 10 days and 21 days after treatment start. Phages reached the lungs and although the phage cocktails were slightly immunogenic, phage injections were well tolerated without obvious adverse effects. No signs of activation of innate or adaptive immune cells were observed; however, both active phage cocktails elicited a minimal humoral response with secretion of phage-specific antibodies. Our findings show that even repetitive injections lead only to a minimal innate and adaptive immune response in naïve mice and suggest that systemic phage treatment is thus potentially suitable for treating bacterial lung infections.

show abstract

Cytokine Milieu in Infectious Disease: A Sword or a Boon?

Cited by 5 publications

References 108 publications

Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T_x MXene

Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T_x MXene

Differentially expressed genes in the femur cartilage transcriptome clarify the understanding of femoral head separation in chickens

Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice

Contact Info

Product

Resources

About

Cytokine Milieu in Infectious Disease: A Sword or a Boon?

Cited by 5 publications

References 108 publications

Ultraefficiently Calming Cytokine Storm Using Ti3C2Tx MXene

Ultraefficiently Calming Cytokine Storm Using Ti3C2Tx MXene

Differentially expressed genes in the femur cartilage transcriptome clarify the understanding of femoral head separation in chickens

Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice

Contact Info

Product

Resources

About

Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T_x MXene

Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T_x MXene