Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa

Kahl, Kai G.; Kruse, Nils; Rieckmann, Peter; Schmidt, Martin H.

doi:10.1016/s0306-4530(02)00131-2

Cited by 55 publications

(47 citation statements)

References 29 publications

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“…Several authors reported normal [11,17,18], decreased [25], or increased IL-1β levels [10,14]; normal [11,15,[17][18][19] or increased IL-6 concentrations [1,9,12] as well as normal [11,[17][18][19] or increased TNF-α levels [12,13,16], compared to healthy weight controls. Our female adolescents with AN exhibited a significant in- crease in serum IL-1β (similar to the study participants of Allende et al [10] and Ziora et al [14]), IL-6 (similar to the study participants of Pomeroy et al [9], Kahl et al [12], and Misra & Klibansky [1]), and TNF-α (similar to study participant of Nakai et al [11], Kahl et al [12], and Angello et al [13]). The above-mentioned inter-study discrepancies in IL-1β, IL-6, or TNF-α levels in patients with AN might be due to differences in group size; the number of participants was often quite small [3], which clearly affected the results of statistical analyses.…”

Section: Discussionmentioning

confidence: 99%

“…The most significant differences were reported regarding the levels of circulating pro-inflammatory cytokines. Some researchers found an increase in circulating IL-1β, IL-6, or TNF-α in patients with AN compared to healthy individuals [9][10][11][12][13][14]. Others did not find significant differences in the concentrations of these cytokines between the study and control groups [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Wybrane cytokiny prozapalne, metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u dziewcząt z jadłowstrętem psychicznym

Ostrowska

Ziora

Oświęcimska

et al. 2015

Endokrynologia Polska

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Wybrane cytokiny prozapalne, metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u dziewcząt z jadłowstrętem psychicznym

Ostrowska

Ziora

Oświęcimska

et al. 2015

Endokrynologia Polska

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“…Studies focusing on changes in gene expression in psychiatric patients most often regard diseases such as schizophrenia (Freudenreich et al, 2010;Chase et al, 2015), depression (Horowitz et al, 2014), and anorexia (Kahl et al, 2004). According to Arion et al (2007) overexpression of HSPA1A and HSPB1 during the developmental process might be related to occurrence of schizophrenia, whereas Freudenreich et al (2010) reported immune response disorders in patients suffering from this illness.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on gene expression in patients suffering from depression have begun relatively recently (Kahl et al, 2004). One of the hypotheses that explains the biological background of depression suggests that it may be the result of chronic inflammatory processes (Devorak et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

CASE-REPORT Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker

Trystuła

Żychowska²,

Wilk-Frańczuk³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-"warning stroke" depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patient was tested for seven genes associated with the stress reaction: HSPA1A, HSPB1, IL6, IL10, CRP, and HSF-1 along with NF-κB, compared to gene expression in health controls. A 54-year-old patient with a past history of schizophrenia (at the age of 20), and of transient ischemic attack (at the age of 53) and depressive disorder confirmed by functional, cognitive, emotional, and affectional diagnostics underwent additional testing for expression of the genes associated with stress response. The expression of genes coding for heat shock protein (HSPA1A, HSPB1), interleukins (IL6, IL10), and C-reactive protein was tested along with factors that regulate their expression. The results of the tests conducted on this patient were compared with 42 healthy control subjects. Diagnostic testing revealed upregulation in expression of these genes, presenting as increased expression of the target genes and of the regulatory genes. A post-"warning stroke" depressive disorder appears to be associated with overexpression of the genes coding for HSP and interleukins. Further research on larger groups of people may provide grounds for treatment modification.

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“…Interestingly, all values were reversible and normalized after weight gain. Kahl et al [29] observed increased levels of TNF-␣ and IL-6 mRNA expression in AN patients at admission as compared to healthy controls: the TNF-␣ remained significantly higher in formerly anorectic patients, while the IL-6 mRNA expression decreased.…”

mentioning

confidence: 96%

Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders

Ahrén-Moonga¹,

Lekander²,

Blixen³

et al. 2010

Neuropsychobiology

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Background: The underlying pathophysiology of eating disorders (ED) is dependent on complex interactions between psychological, biological and social factors. The purpose of the present study was to examine a possible increase in cytokines indicating inflammation, as measured by tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in ED patients, and to explore possible relationships between cytokines and self-reported personality traits. Methods: Female patients with severe ED (n = 26) were recruited consecutively from an inpatient clinic and were compared to age-matched healthy females (n = 12). Commercial ELISA tests developed for the measurement of serum levels of TNF-α and IL-6 were employed. Personality traits were measured using Karolinska Scales of Personality. Results: The patient group displayed increased levels of the cytokine TNF-α and a tendency towards increased IL-6 levels. Spearman’s rank correlation coefficient was used to examine possible relationships between levels of cytokines and personality traits. The results showed that IL-6 levels were positively related to both somatic and psychic anxiety and to aggression scales, such as irritability and suspicion. Increased levels of TNF-α, in turn, were significantly correlated with high scores on the depression-related anxiety scale Inhibition of Aggression. However, increased levels of cytokines in the ED group did not seem to be mainly associated with symptoms of depression. Conclusion: We cannot rule out the possibility that comorbid conditions in the group contribute to the higher cytokine values. Further studies need to explore the possible influence of cytokines on the severity of ED and whether this might be mediated or moderated by specific personality traits.

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Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa

Cited by 55 publications

References 29 publications

Wybrane cytokiny prozapalne, metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u dziewcząt z jadłowstrętem psychicznym

Wybrane cytokiny prozapalne, metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u dziewcząt z jadłowstrętem psychicznym

CASE-REPORT Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker

Levels of Tumour Necrosis Factor-Alpha and Interleukin-6 in Severely Ill Patients with Eating Disorders

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