Cytokine mRNA Profile in Lipoid Nephrosis: Evidence for Increased IL-8 mRNA Stability

Laflam, Paul; Haraguchi, Soichi; Garin, Eduardo H.

doi:10.1159/000065022

Cited by 15 publications

(9 citation statements)

References 20 publications

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“…Elevated IL-2 and IL-10 mRNA levels were documented in patients during relapse, by Shimoyama and colleagues [33]. In our studies, we were unable to detect IL-2 or IL-4 mRNA in the same types of patients [49]. In contrast, Cho et al found elevated spontaneous mRNA expression of IL-4 in IMLNS patients in relapse [28].…”

Section: Cytokine Pattern According To Mrna Expression In Imlns Patiecontrasting

confidence: 80%

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A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome

et al. 2006

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Idiopathic minimal lesion nephrotic syndrome (IMLNS) was proposed to be a disorder of T-cell dysfunction by Shalhoub in 1974. The mechanisms by which T-cells increase glomerular permeability have remained elusive (and unproven). There is evidence that IMLNS may be due to a circulating factor released from activated T-cells. In recent years, efforts have been made to identify this pathogenetic cytokine as well as to understand the mechanism(s) for the increased release of this factor. This review attempts to critically analyze the available published data. Using different methodologies, investigators have focused on the production of cytokines in patients with IMLNS during relapse and remission. This has resulted in a plethora of data without definitive conclusions. The pathogenetic cytokine has not been identified, and it is questionable whether there is a Th2 dominance in IMLNS. The review of the available data illustrates the difficulties encountered when one is studying the cytokine secretory pattern in patients with IMLNS. Differences in patient population, type of cells studies, sample preservation, and methodology used to measure cytokines are some of the factors that could account for the disparity of observed results.

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Section: Cytokine Pattern According To Mrna Expression In Imlns Patiecontrasting

confidence: 80%

“…[36] ↑/N Laflam et al [49] N D ↑/N N/N N/N N/N No biopsy data Bustos et al [37] ↑/N Cho et al [28] ↑ Yap et al [29] N/N N/N N/N ↑/N Shimoyama et al [33] ↑/N N/N N/N ↑/N N/N Intracellular cytokine detection in IMLNS patients in relapse…”

Section: Cytokine Pattern According To Mrna Expression In Imlns Patiementioning

confidence: 99%

A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome

et al. 2006

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“…However, the Northern blot technique does not allow the accurate quantitation of signals and the data might be less reliable than ours. Laflam et al [20] used a ribonuclease protection assay to measure the mRNA expression of IL-4, IL-8, TNF-a, TGFb1, VPGF, IFN-g, Rantes, and MCP-1 in children with INS. They reported that only IL-8 expression was significantly higher in relapse than in remission, but this was not based on paired data.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of interleukin-2 mRNA in children with idiopathic nephrotic syndrome

et al. 2004

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The current hypothesis for the pathogenesis of childhood idiopathic nephrotic syndrome (INS) favors the involvement of a T cell-mediated immune response. Various cytokines derived from T cells may play a critical role in INS. Previous studies have measured serum or urine cytokine levels and suggest an imbalance of the T cell-mediated immune response. To elucidate the true profile of T cell-derived cytokines, we determined interleukin (IL)-2, interferon (IFN)-gamma, IL-4, IL-10, and tumor necrosis factor (TNF)-alpha mRNA expression in children with INS. We collected mRNA from peripheral blood mononuclear cells together with plasma and urine from nine children in the acute and remission phases of INS. Expression of IL-2, IFN-gamma, IL-4, IL-10, and TNF-alpha mRNA was determined by a quantitative real-time PCR assay. Plasma and urine cytokine concentrations were measured using a specific enzyme-linked immunosorbent assay. These data were compared between the acute and remission phase in the same patients. The IL-2 mRNA levels were significantly higher in the acute phase than in the remission phase, whilst no significant difference was found in the other cytokines investigated. There was no significant difference in the plasma and urine cytokine concentrations between the acute and remission phase. Our results indicate increased expression of IL-2 mRNA in the acute phase of INS, suggesting that IL-2, at least in part, might be involved in the pathophysiology of childhood INS.

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“…It has also been shown that the serum level of IL-8 and the stability of IL-8 mRNA increase in patients with minimal change disease [8]. It has been reported that patients with polycythemia vera have high serum and bone marrow plasma levels of IL-8 and IL-11 and also increased secretion of these two interleukins from the bone marrow stromal cells [9].…”

Section: Discussionmentioning

confidence: 99%

A Unique Form of Polycythemia Associated with Minimal Change Disease

Balal¹,

Seyrek²,

Karayaylalı³

et al. 2004

Med Princ Pract

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Objective: To present a case with nephrotic syndrome due to minimal change disease and polycythemia. Clinical Presentation and Intervention: A 20-year-old female was admitted to our clinic for edema and severe proteinuria present with minimal change disease since the age of 7 years. Polycythemia was found during the last activation of nephrotic syndrome. The patient was placed on glucocorticoid therapy that caused disappearance of edema, proteinuria and polycythemia. Ten months later both hemoglobin and hematocrit levels were within normal range. Conclusion: This patient with nephrotic syndrome due to minimal change disease and polycythemia was successfully treated with glucocorticoid.

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Cytokine mRNA Profile in Lipoid Nephrosis: Evidence for Increased IL-8 mRNA Stability

Cited by 15 publications

References 20 publications

A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome

A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome

Up-regulation of interleukin-2 mRNA in children with idiopathic nephrotic syndrome

A Unique Form of Polycythemia Associated with Minimal Change Disease

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