Cytokine production against common dietary proteins in patients with autism spectrum disorder and developmental regression in comparison with patients with dietary protein intolerance

Jyonouchi, Harumi; Sun, Sining; Le, Hoa; Itokazu, Nanae

doi:10.1016/s0091-6749(02)81802-4

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Environmental Factors1

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2008

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“…A few reports have described overproduction of proinflammatory cytokines in children with RASD (Jyonouchi et al 2001;Jyonouchi et al 2002), which may relate to sensitivity to common dietary proteins and leading to GI inflammation and aggravation of some behavioral symptoms.…”

Section: Environmental Factorsmentioning

confidence: 99%

Regression in Autistic Spectrum Disorders

2008

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A significant proportion of children diagnosed with Autistic Spectrum Disorder experience a developmental regression characterized by a loss of previously-acquired skills. This may involve a loss of speech or social responsitivity, but often entails both. This paper critically reviews the phenomena of regression in autistic spectrum disorders, highlighting the characteristics of regression, age of onset, temporal course, and long-term outcome. Important considerations for diagnosis are discussed and multiple etiological factors currently hypothesized to underlie the phenomenon are reviewed. It is argued that regressive autistic spectrum disorders can be conceptualized on a spectrum with other regressive disorders that may share common pathophysiological features. The implications of this viewpoint are discussed.

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Section: Environmental Factorsmentioning

confidence: 99%