Cytokine Production from Peripheral Blood Mononuclear Cells in Patients with Ankylosing Spondylitis and Their First-Degree Relatives

Chou, Chen‐Te; Huo, An-Ping; Chang, Hsiao-Ning; Tsai, Chang‐Youh; Chen, Weisheng; Wang, Hon-Pin

doi:10.1016/j.arcmed.2006.09.008

Cited by 20 publications

(13 citation statements)

References 30 publications

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“…In our study, IL-10 levels were statistically lower in AS patients than in controls. Therefore, our findings are more in agreement with those of Chou et al [31] in terms of low levels of IL-10 in AS patients compared to the controls. However, we did not observe any negative correlation between BASDAI and IL-10 levels in the AS group.…”

Section: Discussionsupporting

confidence: 93%

“…The role of IL-10 in the pathogenesis of AS has also been well-studied [10,[31][32][33]. Interleukin-10 is known to inhibit the release of MIF and has been described as a potent macrophage deactivator via the inhibition of cytokine production by activated macrophages [11].…”

Section: Discussionmentioning

confidence: 99%

“…These researchers suggested that IL-10 and MIF are parts of a negative regulatory circuit in which IL-10 counteracts MIF-induced inflammatory processes [7]. Chou et al [31] recently reported a negative correlation between BASDAI and IL-10 levels produced by PBMCs in AS patients, whereas Vazquez-Del et al [35] showed no difference in the median levels of TNF-a or IL-10 between AS and controls. In our study, IL-10 levels were statistically lower in AS patients than in controls.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

et al. 2009

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Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Mediators such as macrophage migration inhibitory factor (MIF) and interleukin-10 (IL-10) are thought to be involved in several inflammatory conditions, including AS. Proinflammatory cytokines regulate the production of oxidative stress markers, such as nitric oxide (NO) and malondialdehyde (MDA). Although oxidative stress and lipid peroxidation have been reported in AS, the association of AS with commonly known oxidative stress markers and cytokines remains uncertain. We have therefore studied whether serum MIF levels are elevated in patients with AS and whether the levels correlate with oxidative stress markers and disease activity parameters. Twenty-five AS patients and 18 healthy controls participated in this study; subjects with hypertension, diabetes, hyperlipidemia, and obesity were excluded. The levels of acute phase reactants, serum levels of glucose, lipids, MIF, IL-10, NO and MDA were studied. Spinal mobility was assessed by the Bath Ankylosing Spondylitis Metrology Index (BASMI). Patients were also assessed using with the Bath Ankylosing Spondylitis Functional Index and the Bath Ankylosing Spondylitis Disease Activity Index. Age and sex distribution were found to be comparable between AS patients and controls (p > 0.05). Acute phase reactants and MIF levels were significantly higher (p < 0.05) and IL-10 levels were significantly lower (<0.001) in the AS patients than in controls. There was a significant correlation between BASMI and MIF levels in AS patients (r = 0.714, p < 0.001). Based on these results, MIF may be involved in the pathogenesis of the chronic inflammation in AS and, consequently, targeting MIF may be beneficial in preventing complications or in initiating early treatment of the disease.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

et al. 2009

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“…Clinical symptoms include the pain in areas including the lumbar, back, shoulder and neck, with or without spasticity. Furthermore, these can include heel pain, pain aggravation at night, even nocturnal awakening, turning difficult and obvious spasticity on waist in the early morning or after sedentary state (2). AS is a systemic autoimmune disease, with final outcomes including ossification of the ligaments around the spine and intervertebral disk, and the fibrosis of axial joints and bony ankylosis, leading to the disability of joint movement (3).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Liu

Shi

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Naringin is an abundant flavanone in pomelo, grapefruit as well as lime and its variants, has been shown to exhibit certain antioxidative, anti-inflammatory, anti-cancer and hypoglycemic effects. The aim of the current study was to evaluate the protective effects of naringin against ankylosing spondylitis (AS) and to elucidate the potential underlying mechanism. Firstly, a mouse model of ankylosing spondylitis (AS) was established. Next, osteocalcin (OC), alkaline phosphatase (ALP) and triglyceride (TG) activity values, inflammatory factor and oxidative stress were evaluated in the AS mice. Then, the Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) protein expression levels in the AS mice were investigated using western blot analysis. The results showed that naringin increased OC, ALP and TG activity values in the AS mouse model. Furthermore, inflammatory factor and oxidative stress levels in the AS mice were restrained by treatment with naringin. Furthermore, JAK2 and STAT3 protein expression levels were reduced by treatment with naringin. In conclusion, the present results indicated that the protective effects of naringin against AS are exerted via the induction of ossification, suppression of inflammation and oxidative stress and the downregulation of JAK2/STAT3 in mice.

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“…This cytokine is known to be present at higher concentrations in patients with AS, RA, and PsA. The important role of TNF in these diseases has been proven by their successful treatment with anti-TNF drugs [166–168], particularly AS patients respond well to TNF- α antagonist therapy [169]. …”

Section: Molecules Their Genes and Asmentioning

confidence: 99%

Ankylosing Spondylitis: From Cells to Genes

Zambrano‐Zaragoza

Agraz‐Cibrián

González-Reyes

et al. 2013

International Journal of Inflammation

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Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it is considered an autoimmune disease. HLA-B27 is the risk factor most often associated with AS, and although the mechanism of involvement is unclear, the subtypes and other features of the relationship between HLA-B27 and AS have been studied for years. Additionally, the key role of IL-17 and Th17 cells in autoimmunity and inflammation suggests that the latter and the cytokines involved in their generation could play a role in the pathogenesis of this disease. Recent studies have described the sources of IL-17 and IL-23, as well as the characterization of Th17 cells in autoimmune diseases. Other cells, such as NK and regulatory T cells, have been implicated in autoimmunity and have been evaluated to ascertain their possible role in AS. Moreover, several polymorphisms, mutations and deletions in the regulatory proteins, protein-coding regions, and promoter regions of different genes involved in immune responses have been discovered and evaluated for possible genetic linkages to AS. In this review, we analyze the features of HLA-B27 and the suggested mechanisms of its involvement in AS while also focusing on the characterization of the immune response and the identification of genes associated with AS.

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Cytokine Production from Peripheral Blood Mononuclear Cells in Patients with Ankylosing Spondylitis and Their First-Degree Relatives

Cited by 20 publications

References 30 publications

Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor

Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice

Ankylosing Spondylitis: From Cells to Genes

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