Cytokine production in children outgrowing hen egg allergy

Noma, Takeshi; Yoshizawa, Izumi; Aoki, Kazutoshi; Yamaguchi, Kouichi; Baba, Minoru

doi:10.1111/j.1365-2222.1996.tb00527.x

Cited by 29 publications

(15 citation statements)

References 40 publications

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“…However, what is less clear is whether the depressed Th1 responses remain depressed during early childhood. Thus, some studies have revealed depressed IFN-γ responses [8], whereas others have shown that IFN-γ responses are increased [9][10][11] in young atopic children compared to their non-atopic counterparts.…”

Section: Introductionmentioning

confidence: 99%

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Larsson

Nilsson

Höglind

et al. 2006

Clinical and Experimental Immunology

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SummaryLittle is known at present about the relation between parental and child cytokine profiles. In this study we aimed to investigate the cytokine profile of 2-year-old children and their corresponding mothers, 2 years after delivery. Peripheral blood mononuclear cells (PBMC) were isolated from IgEsensitized ( n = = = = 15) and non-sensitized ( n = = = = 58) 2-year-old children and their mothers. The responses to ovalbumin, cat and phytohaemagglutinin (PHA) were investigated using the enzyme-linked immunospot (ELISpot) technique. Interferon (IFN)-γ γ γ γ -, interleukin (IL)-4-, IL-10-and IL-12-producing cells were enumerated. At 2 years of age, IgE-sensitized children exhibited increased numbers of IL-4-producing cells in response to PHA and also showed an increase in IL-10-and IL-12-producing cells to allergen that was more pronounced in response to ovalbumin than to cat. A statistically significant increase in the numbers of IFN-γ γ γ γ -, IL-10-and IL-12-producing cells to the allergens, but not to PHA, was found in the mothers of IgE-sensitized children irrespective of their own atopic status. IgE levels and cytokine responses were correlated between the mothers and their children, indicating that cytokine responses to both allergen and PHA might be governed by genetic factors. We speculate that the increased cytokine response to allergen, as opposed to the allergic status of the mother, might be a better predictor and/or a risk factor for the child to develop IgE-sensitization in early life.

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Section: Introductionmentioning

confidence: 99%

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Larsson

Nilsson

Höglind

et al. 2006

Clinical and Experimental Immunology

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“…9 Studies that determined cytokine production in food antigenstimulated PBMCs showed that patients with food allergy have a T H 2-skewed response compared with nonatopic control subjects. [10][11][12][13][14] In these studies, however, cytokines were measured in bulk cultures of T cells, making it difficult to extrapolate these results to the individual T cell. Food-reactive T H 2 cells have been cloned from blood of patients with food allergy, [15][16][17] but the food-specific Tcell response in food-tolerant subjects has not been evaluated at the clonal level.…”

mentioning

confidence: 99%

Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines

Schade

Dijk²,

Reijsen³

et al. 2000

Journal of Allergy and Clinical Immunology

102

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“…Shek et al [26] reported that the rate of decrease in food-specific IgE levels over time was predictive for the likelihood of developing tolerance in both milk and egg allergy. Another study reported that the trigger for outgrowing hen egg allergy and peanut allergy may be due to the induction of Th1 type cells to produce IFN-γ resulting in suppression of the Th2 type response [15,18]. Thus, many studies emphasize that long-lasting (Th2 response) IL-4 and IgE levels are vital for the persistence of food allergies.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, those who remained allergic maintained a Th2-dominated profile [15]. In milk and egg allergy, there are similar reports implicating either Th1/Th2 imbalance or involvement of CD4+ CD25+T regulatory cells in outgrowing clinical sensitivity [16,17,18]. In contrast to these food allergies, the mechanism underlying the persistence of tree nut allergies in general and hazelnut allergy in particular is largely unknown.…”

Section: Introductionmentioning

confidence: 98%

Long-Term Characteristics of Hazelnut Allergy in an Adjuvant-Free Mouse Model

Gonipeta

Parvataneni

Paruchuri

et al. 2010

Int Arch Allergy Immunol

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Background: Clinically it is recognized that tree nut allergies such as hazelnut allergy are not usually outgrown. Specific mechanisms underlying the persistence of such food allergies are incompletely understood. Here we studied the natural history and the long-term immune and clinical characteristics of hazelnut allergy in an adjuvant-free mouse model. Methods: BALB/c mice were sensitized to hazelnut protein using a transdermal sensitization protocol that does not use adjuvant. After establishing sensitization, exposure to hazelnut was withdrawn for 3, 5 or 8 months. The fate of circulating IgE antibodies was monitored. Subsequently, mice were given booster exposures and examined for memory IgE antibody and spleen cell IL-4 responses. Clinical characteristics and hypothermia responses upon oral allergen challenge were studied. Results: Upon allergen withdrawal, circulating hazelnut-specific IgE antibody levels began to drop. Nevertheless, IgE responses once established remained at significantly high levels for up to 8 months (the last time point studied) despite withdrawal of allergen exposure. Memory IgE responses to booster exposures were robust after 3, 5 or 8 months of allergen withdrawal. Furthermore, significant clinical reactivity to oral hazelnut challenge, and hypothermia responses were demonstrable at each of these time points. Long-lasting spleen cell memory IL-4 responses to hazelnut were detectable in these mice explaining the mechanism of sustenance of IgE responses and clinical sensitization. Conclusions: Hazelnut allergy once established persists for long periods, despite withdrawal of allergen exposure, due to long-lasting, memory IgE and IL-4 responses.

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Cytokine production in children outgrowing hen egg allergy

Cited by 29 publications

References 40 publications

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Relationship between maternal and child cytokine responses to allergen and phytohaemagglutinin 2 years after delivery

Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow’s milk allergy: Relevance of TH2 cytokines

Long-Term Characteristics of Hazelnut Allergy in an Adjuvant-Free Mouse Model

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