Cytokine profile in chronic hepatitis C: An observation

Baskić, Dejan; Vuković, Vuk R.; Popović, Suzana; Djurdjević, Predrag; Zarić, Milan; Nikolić, Ivana; Zelen, Ivanka; Mitrović, Marina; Avramovic, Dusko; Mijailović, Željko

doi:10.1016/j.cyto.2017.04.008

Cited by 23 publications

(19 citation statements)

References 12 publications

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“…Our study also confirms that the production of inflammatory cytokines and chemokines is enhanced in patients with chronic HCV infection and is downregulated by viral eradication . Indeed, antiviral therapy significantly improved IL1‐ra, IL2, IL5, FGF‐basic, GM‐CSF, IFN‐gamma, CCL2, CCL3, CCL4, CCL11, CXCL10, PDGF‐BB, and TNF‐alpha plasma levels.…”

Section: Discussionsupporting

confidence: 83%

“…Indeed, this result may be affected by the relatively short follow-up period, as the evaluation of these parameters was performed 1 year after the end of the DAA treatment, and also by the fact that only patients with well-compen- Our study also confirms that the production of inflammatory cytokines and chemokines is enhanced in patients with chronic HCV infection and is downregulated by viral eradication. [28][29][30][31][32][33][34][35][36][37] Indeed, antiviral therapy significantly improved IL1-ra, IL2, IL5, FGF-basic, , faecal calprotectin) before and 1 y after the end of direct-acting antiviral (DAA) treatment. IL: interleukin; ra:receptor agonist; FGF: fibroblast growth factor; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocytemacrophage colony-stimulating factor; IFN: interferon; CCL: C-C motif chemokine ligand; CXCL: C-X-C motif chemokine ligand; PDGF: plateletderived growth factor; TNF: tumour necrosis factor GM-CSF, IFN-gamma, CCL2, CCL3, CCL4, CCL11, CXCL10, PDGF-BB, and TNF-alpha plasma levels.…”

Section: P-value (Hcv Post-daa Vs Controls)mentioning

confidence: 99%

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Influence of hepatitis C virus eradication with direct‐acting antivirals on the gut microbiota in patients with cirrhosis

Ponziani

Putignani

Sterbini

et al. 2018

Aliment Pharmacol Ther

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Summary Background The cure of hepatitis C virus (HCV) infection may contribute to the reduction of liver fibrosis progression and potentially influence the gut‐liver axis. Aim To investigate the influence of HCV infection eradication with direct‐acting antivirals (DAAs) on the gut microbiota composition as well as on intestinal and systemic inflammatory parameters in patients with cirrhosis. Methods Consecutive patients with HCV‐related cirrhosis receiving DAA treatment were included. The gut microbiota composition, intestinal permeability, and inflammation were assessed before treatment and after 1 year. Clinical outcomes such as episodes of decompensation and markers of liver fibrosis were evaluated over a 2‐year follow‐up period. Results The gut microbiota alpha diversity in cirrhotic patients, which was lower than that in healthy subjects, was significantly improved by the cure of HCV infection and a shift in the overall gut microbiota composition was observed compared to baseline. The abundance of potentially pathogenic bacteria (Enterobacteriaceae, Enterococcus, and Staphylococcus) was decreased after treatment. The gut microbiota composition was associated with the inflammatory profile and markers of liver fibrosis. Although a significant reduction in the serum levels of cytokines and chemokines was observed post‐DAA treatment, measures of intestinal permeability and inflammation remained unchanged. Conclusions Cure of HCV infection with DAAs in patients with cirrhosis is associated with a modification of the gut microbiota, which correlates with fibrosis and inflammation but does not improve intestinal barrier function.

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Section: Discussionsupporting

confidence: 83%

Section: P-value (Hcv Post-daa Vs Controls)mentioning

confidence: 99%

Influence of hepatitis C virus eradication with direct‐acting antivirals on the gut microbiota in patients with cirrhosis

Ponziani

Putignani

Sterbini

et al. 2018

Aliment Pharmacol Ther

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“…Also, immune and hepatic cells contribute to viral control, establishment and maintenance of inflammation, and progression to liver fibrosis or tissue regeneration [ 8 ]. Overall, studies describe an increase in serum cytokine levels in chronic hepatitis C patients, when compared with healthy individuals [ 9 – 12 ]. Therefore, exploiting circulating cytokine array and noninvasive fibrotic biomarkers after interferon- (IFN-) free antiviral therapy with second-generation DAA may contribute to a better understanding about the pattern of these mediators in chronic hepatitis C pathogenesis, progression of liver disease, therapeutic responses, and even persistent infection pathways.…”

Section: Introductionmentioning

confidence: 99%

Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C

Saraiva

Rosário

Medeiros

et al. 2018

Mediators of Inflammation

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This study aimed at analyzing circulating levels of inflammatory and profibrogenic cytokines in patients with hepatitis C virus (HCV) chronic infection undergoing therapy with direct-acting antiviral agents (DAA) and correlating these immune biomarkers with liver disease status. We studied 88 Brazilian monoinfected chronic hepatitis C patients receiving interferon- (IFN-) free sofosbuvir-based regimens for 12 or 24 weeks, followed-up before therapy initiation and three months after the end of treatment. Liver disease was determined by transient elastography, in addition to APRI and FIB-4 indexes. Analysis of 30 immune mediators was carried out by multiplex or enzymatic immunoassays. Sustained virological response rate was 98.9%. Serum levels of cytokines were increased in HCV-infected patients when compared to control group. CCL-2, CCL-3, CCL-4, CXCL-8, CXCL-10, IL-1β, IL-15, IFN-γ, IL-4, IL-10, TGF-β, FGFb, and PAI-1 decreased significantly after antiviral therapy, reaching values similar to noninfected controls. TGF-β and suPAR levels were associated with fibrosis/cirrhosis. Also, we observed amelioration in hepatic parameters after DAA treatment. Together, our results suggest that viral control induced by IFN-free DAA therapy restores inflammatory mediators in association with improvement in liver function.

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“…This response can inhibit or limit microbial growth but also can cause host damage, and so it is necessary to keep this response under control; to achieve this, the host performs some strategies, including the production of cytokines. These molecules play an important role in intercellular communication and coordinate the innate and adaptive response [35].…”

Section: Cytokine Profile In Bacterial Infectionsmentioning

confidence: 99%

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

Muñoz‐Carrillo¹,

Contreras-Cordero²,

Gutiérrez-Coronado³

et al. 2019

Immune Response Activation and Immunomodulation

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Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response that recognizes pathogenassociated molecular patterns (PAMPs) and an antigen-specific adaptive immune response. In both responses, there are several activated cells of the immune system, which play a key role in establishing the environment of cytokines, thus directing their differentiation either suppressing or promoting the immune response. This immune response is crucial against pathogen infections. In this chapter, we will describe the crucial role played by different families of cytokines during activation of the immune system to eliminate infectious pathogens.

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Cytokine profile in chronic hepatitis C: An observation

Cited by 23 publications

References 12 publications

Influence of hepatitis C virus eradication with direct‐acting antivirals on the gut microbiota in patients with cirrhosis

Influence of hepatitis C virus eradication with direct‐acting antivirals on the gut microbiota in patients with cirrhosis

Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

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