Cytokine Profile in Piglets With Actinobacillus Pleuropneumonia and Its Correction With Tsipropig

Shakhov, A. G.; Sashnina, L. Yu.; Vladimirova, Yu.Yu.; Adodina, M.I.

doi:10.17238/issn2072-2419.2021.3.60

Cited by 2 publications

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“…Attaching special attention to the development mechanism of severe course of the Perfringens disease it can be stated that it is endowed with high morbidity and mortality. According to the authors, in the pig-breeding farms of Hungary massive losses of piglets occurred due to Perfringens, which is followed by annual outbreaks for a long period (Altukhov and Dushenin, 1987;Urguev, 1987;Kudryashov, 1990;Satio, 1990;Czanderlova, et al, 2006;Salimov, 2006;Kudryashov and Svyatkovskiy, 2007;Sargsyan, 2012;Sidorchuk and Masimov, 2024). Complications of enteritis in newborn piglets can be caused by opportunistic bacteria, viruses and endoparasites belonging to the genera Escherichia coli and Salmonella.…”

Section: A R T I C L E I N F Omentioning

confidence: 99%

Epidemiological Analysis of the Swine Perfringens Disease in the Aragatsotn Region

Sargsyan

2024

AgriScience and Technology

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Over the recent 20 years, for the first time, the disease of swine perfringens has been studied in the Aragatsotn region of RA and related epidemiological analysis has been conducted. To identify A, C, and D serological types of Cl. Perfringens and special diagnostic sera produced by the Kursk biofactory were used. It has been found that the main serological infection type of swine perfringens is C and sometimes A and D subtypes. In the pig breeding farms of the mentioned region about 6887 heads of swine (aging from 3 days to 1 year old) were registered. Per the research results, about 45 out of 72 communities were recognized as insecure/vulnerable. As to the above-stated animal number, it should be mentioned, that 1722 heads of swine fell down, whereas 5510 were considered bacteria carriers. Thus, as a result of epidemiological analysis, the morbidity (bacteria carrying rate), mortality, insecurity/vulnerability, and focality coefficients (indicators) have made 0.80 (80 %), 0.25 (25 %), 0.63 (63 %), and 122 animals, respectively.

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Section: A R T I C L E I N F Omentioning

confidence: 99%

Epidemiological Analysis of the Swine Perfringens Disease in the Aragatsotn Region

Sargsyan

2024

AgriScience and Technology

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Formation of specific immunity in piglets during vaccination against circovirus infection

Shakhov,

Sashnina,

Vladimirova

et al. 2023

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The article presents the results of studying the formation of specific immunity in piglets during vaccination against circovirus infection. Circovirus diseases of pigs, manifested by the defeat of many body systems, are widespread and cause great economic damage in industrial pig farms. The study of the formation of specific immunity during vaccination of piglets against circovirus infection is of scientific and practical interest. The purpose of the research is to study the formation of specific immunity in piglets during vaccination against circovirus infection. It was found that vaccination is accompanied by activation of the innate immunity system, which initiated the launch and formation of an antigen-specific adaptive immune response. In animals 6 days after the introduction of the vaccine, compared with intact piglets, an increase in the content of pro-inflammatory cytokines IL-1ß, TNF-α, IFN-α and IFN-γ and the anti-inflammatory mediator IL-4 was found, indicating a cellular and humoral immune response. An increase in the indices of inflammatory activity of mediators and the ratio of pro- and anti-inflammatory cytokines indicates an increase in the activity of T-helper I and the prevalence of cellular immune response. Under the influence of technological stress caused by weaning from sows and transfer to rearing, animals 14 days after vaccination showed a decrease in the level of IL-2, IFN-α and IFN-γ, inducing cellular immunity, as well as cytokine index, the ratio of pro- and anti-inflammatory mediators, which indicates a shift in the direction of the immune response in the side of activation of the functioning of T-helper II, indicating the predominant formation of humoral immunity.

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Cytokine Profile in Piglets With Actinobacillus Pleuropneumonia and Its Correction With Tsipropig

Cited by 2 publications

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Epidemiological Analysis of the Swine Perfringens Disease in the Aragatsotn Region

Epidemiological Analysis of the Swine Perfringens Disease in the Aragatsotn Region

Formation of specific immunity in piglets during vaccination against circovirus infection

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