Cytokine profile, metabolic syndrome and cardiovascular disease risk in women with late-onset gestational diabetes mellitus

López-Tinoco, Cristina; Roca, M.; Fernández-Deudero, Álvaro; Garcia-Valero, Amor; Bugatto, Fernando; Diosdado, Manuel Aguilar; Bartha, José Luis

doi:10.1016/j.cyto.2011.12.004

Cited by 85 publications

(59 citation statements)

References 42 publications

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“…Several studies have investigated the inflammatory response and cytokine production of women with GDM compared with healthy pregnant controls. While some authors report increased TNF-A levels in GDM, [16][17][18][19][20][21][22] others do not confirm this association. [23][24][25][26][27][28] Similar controversies also exist regarding IL-10, with study showing lower levels of this anti-inflammatory cytokine in patients with GDM 29 whereas others do not confirm these findings.…”

Section: Introductionmentioning

confidence: 64%

“…Most of the studies assessed cytokine levels in serum (11/22) 16,18,21,24,26,28,[39][40][41][42]46 or plasma (9/22) 17,19,20,22,25,27,29,44,45 samples. Commercial immunoenzymatic assay (ELISA) kits were used for cytokine analyses in almost all studies (18/22).…”

Section: Resultsmentioning

confidence: 99%

“…After screening titles and abstracts, 31 references were selected for full-text reading [16][17][18][19][20][21][22][23][24][25][26][27][28][29][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] and 23 citations reporting on 22 studies were included in this review (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…Only seven studies provided description of sample collection (i.e., tubes, anticoagulant) and storage (temperature, time) details. [23][24][25][26][27][28]44 Cytokines Nine cytokines were analyzed in the 22 included studies, TNF-A was the most frequently investigated cytokine [16][17][18][19][20][21][22][23][24][25][26][27][28]40,41 followed by IL-6 17,23,27,29,39,42,45 and IL-10. 23,25,27,29 Almost 70% of the studies assessed only one cytokine.…”

Section: Resultsmentioning

confidence: 99%

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Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

100

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CitationGomes CP, Torloni MR, Gueuvoghlanian-Silva BY, Alexandre SM, Mattar R, Daher S. Cytokine levels in gestational diabetes mellitus: a systematic review of the literature. Am J Reprod Immunol 2013; 69: 545-557 doi:10.1111/aji.12088 Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of StudyThree electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. ResultsTwenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD = 0.45, 95% CI À0.34-1.23). ConclusionsNew studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.

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Section: Introductionmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

100

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“…This is also the case for diabetes in pregnancy -gestational diabetes mellitus (GDM) (1,2). The association between GDM and adverse pregnancy outcomes is well documented (3,4,5,6). The linear association between increasing maternal blood glucose levels and adverse pregnancy outcomes has raised the question of which criteria should be used for GDM diagnosis (7).…”

Section: Introductionmentioning

confidence: 99%

Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria

Helseth

Salvesen

Carlsen

2013

European Journal of Endocrinology

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Objective: The consequences of the recently proposed International Association of Diabetes in Pregnancy Study Group (IADPSG) criteria for gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) are not known. We compared the prevalence rates and risk factors for GDM in PCOS women according to both the WHO and the modified IADPSG criteria. Design: Post hoc analyses from a randomized, multicenter study were used. Methods: Fasting and 2-h plasma glucose levels were measured using a 75 g oral glucose tolerance test. GDM was diagnosed according to both the WHO and the modified IADPSG criteria.Results: The prevalence rates of GDM according to the WHO and the modified IADPSG criteria were 9.2 and 15.0% at week 12, 18.7 and 18.7% at week 19, and 25.6 and 24.2% at week 32. Shorter stature and increased insulin levels were correlated with WHO-GDM, but not with modified IADPSG-GDM at weeks 12 and 19. Less weight gain in pregnancy predicted GDM according to both sets of criteria. GDM diagnosis was correlated with less maternal weight loss the first year post-partum. Conclusions: No difference was found in the prevalence of GDM between the two sets of criteria used. Less weight gain in pregnancy was associated with GDM, independent of the diagnostic criteria used. Reduced weight loss the first year post-partum in women with GDM raises the question of whether GDM diagnosis per se or the fact that these women lose less weight after pregnancy predicts later diabetes mellitus.

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Obesity and Diabetes in Pregnancy

McIntyre

Nitert

Barrett

et al. 2017

A Practical Manual of Diabetes in Pregnancy

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Cytokine profile, metabolic syndrome and cardiovascular disease risk in women with late-onset gestational diabetes mellitus

Cited by 85 publications

References 42 publications

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gestational diabetes mellitus among Norwegian women with polycystic ovary syndrome: prevalence and risk factors according to the WHO and the modified IADPSG criteria

Obesity and Diabetes in Pregnancy

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