Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis

Ruiz-Cruz, Matilde; Ávila‐Ríos, Santiago; Ormsby, Christopher E.; Ablanedo-Terrazas, Yuria; Barrera, Claudia Alvarado-de la; Kuri-Cervantes, Leticia; Reyes‐Terán, Gustavo

doi:10.1080/09273948.2016.1268170

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…Detectable CMV DNA in the intraocular fluid is crucial for CMV retinitis diagnosis and differentiation from primary FBA or other infections. The elevated levels of IL-8 and IL-6 (principal cellular sources from monocytes and macrophages) in the AqH, as an indicator of active retinitis, obviously decreased following the anti-CMV treatment [ 3 – 5 ]. In this case, anti-CMV treatment monotherapy decreased the CMV DNA load as well as IL-8 and IL-6 levels in the AqH.…”

Section: Discussionmentioning

confidence: 99%

Frosted branch angiitis due to cytomegalovirus-associated unmasking immune reconstitution inflammatory syndrome: a case report and literature review

et al. 2021

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Background Cytomegalovirus (CMV) retinitis is a common opportunistic infection in patients with acquired immunodeficiency syndrome. The common funduscopic manifestations are haemorrhagic necrotising variety and granular variety. Frosted branch angiitis (FBA), as a special form, when it occurred after antiretroviral therapy(ART), could possibly be associated with immune reconstitution. We report a case of FBA secondary to CMV infection-associated unmasking immune reconstitution inflammatory syndrome (IRIS). Case presentation A 27-year-old man with human immunodeficiency virus infection developed FBA after 35 days of ART. The left Aqueous humour (AqH) tested positive for CMV DNA, and the patient was diagnosed with CMV retinitis. The degree of intraocular inflammation was reflected by increased levels of interleukin (IL)-6 and IL-8 in AqH. After anti-CMV treatment and continuous ART for several months, his FBA and vision significantly improved. CMV DNA became undetectable in the left AqH, and the IL-6 and IL-8 levels in AqH decreased. Conclusion FBA could be a sign of CMV-associated unmasking IRIS. Anti-CMV treatment alone or combination with steroid treatment may be administered, depending on the changes in CMV DNA load and immunologic profile of AqH.

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Section: Discussionmentioning

confidence: 99%

Frosted branch angiitis due to cytomegalovirus-associated unmasking immune reconstitution inflammatory syndrome: a case report and literature review

et al. 2021

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“…IL-10 also has direct inhibitory effects on many CD4 T cell subtypes, inducing anergy, nonresponsiveness, and a reduction of cytotoxicity ( 16 , 17 ). IL-10 secretion correlates with a higher viral load during CMV reactivations in sepsis patients, in lower respiratory tract samples from critically ill patients, in HIV positive patients with CMV retinitis, and in solid organ transplant (SOT) recipients ( 14 , 18 , 19 ). Interestingly, the increase of IL-10 in SOT recipients is closely linked to a suppression of CMV-specific T cell responses ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Human Cytomegalovirus pUL11, a CD45 Ligand, Disrupts CD4 T Cell Control of Viral Spread in Epithelial Cells

Osanyinlusi

Zischke

Jacobs

et al. 2022

mBio

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“…Human immunodeficiency virus (HIV) is a lentivirus that infects cells of the human immune system, causing its dysfunction ( 1 ). In 2017, an estimated 36.9 million people worldwide had HIV infection, according to the World Health Organization ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Vogt-Koyanagi-Harada Syndrome Mimicking Acute Angle-Closure Glaucoma in a Patient Infected With Human Immunodeficiency Virus

Bai

Hua

2022

Front. Med.

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Vogt-Koyanagi-Harada disease (VKH) is a rare multisystemic inflammatory autoimmune disorder. Glaucoma secondary to VKH frequently occurs during the recurrent phase of anterior uveitis; however, acute angle-closure glaucoma (ACG) secondary to both VKH and human immunodeficiency virus (HIV) infection has rarely been reported. We describe a case of secondary acute ACG involving VKH, characterized by sudden vision loss, moderately elevated intraocular pressure (IOP), shallow anterior chamber, and fully or partially closed angle, in an HIV-infected patient. Both VKH and HIV infection contributed to the occurrence of ACG due to the leakage and forward rotation of the ciliary body, as well as choroidal effusion. The deterioration of IOP and serous macular detachment were observed after initial corticosteroid therapy. Visual acuity and IOP were improved with subretinal fluid absorption after continued corticosteroid therapy. Understanding the response of IOP and serous macular detachment after corticosteroid therapy is important for clinical practice.

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Cytokine Profiles in Aqueous Humor and Plasma of HIV-infected Individuals with Ocular Syphilis or Cytomegalovirus Retinitis

Cited by 6 publications

References 30 publications

Frosted branch angiitis due to cytomegalovirus-associated unmasking immune reconstitution inflammatory syndrome: a case report and literature review

Frosted branch angiitis due to cytomegalovirus-associated unmasking immune reconstitution inflammatory syndrome: a case report and literature review

Human Cytomegalovirus pUL11, a CD45 Ligand, Disrupts CD4 T Cell Control of Viral Spread in Epithelial Cells

Case Report: Vogt-Koyanagi-Harada Syndrome Mimicking Acute Angle-Closure Glaucoma in a Patient Infected With Human Immunodeficiency Virus

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