Cytokine Profiles in Japanese Patients with Chronic Rhinosinusitis

Sejima, Takayuki; Holtappels, Gabriële; Kikuchi, Hisashi; Imayoshi, Shoichiro; Ichimura, Keiichi; Bachert, Claus

doi:10.2332/allergolint.10-oa-0290

Cited by 45 publications

(41 citation statements)

References 26 publications

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“…It is widely accepted that the cytokine expression in the paranasal mucosa of CRSwNP patients differs from that of CRSsNP patients [6, 12, 13]. In fact, nasal polyp tissue, when compared with adjacent inflammatory nasal mucosa, was shown to express higher levels of IL-5 and lower levels of TGF-β mRNA.…”

Section: Discussionmentioning

confidence: 99%

“…The cytokine profile of the ethmoid sinus mucosa and nasal polyps in ECRS or chronic rhinosinusitis with nasal polyp (CRSwNP) patients has been reported previously. Ethmoid sinus mucosa of CRSwNP patients showed significantly increased expression of interleukin (IL)-5, eosinophil-cationic protein, immunoglobulin E (IgE), and Staphylococcus enterotoxin (SAE)-IgE compared with chronic rhinosinusitis without nasal polyp (CRSsNP) patients [5, 6]. Ethmoid sinus mucosa of ECRS patients also showed significantly elevated expression of inducible nitric oxide synthase (iNOS) and IL-5 [7, 8].…”

Section: Introductionmentioning

confidence: 99%

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IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

Kubota

Takeno

Taruya

et al. 2017

Journal of Otolaryngology - Head & Neck Surgery

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BackgroundEosinophilic chronic frontal sinusitis is difficult to treat compared with non-eosinophilic sinusitis because of recurring inflammation and polyp formation in the frontal recess after the post-operative follow-up period. Studying inflammatory mediators in the frontal recess of eosinophilic chronic rhinosinusitis (ECRS) patients and non-eosinophilic chronic rhinosinusitis (non-ECRS) patients may lead to a better understanding of the pathogenesis of chronic frontal sinusitis.MethodsHomogenates of sinonasal mucosa from 20 non-ECRS patients and 36 ECRS patients were measured for levels of transforming growth factor (TGF)-β, interleukin (IL)-5, IL-6, and inducible nitric oxide synthase (iNOS) using real-time RT-PCR and TaqMan gene expression assays. Sinonasal mucosal specimens were obtained from the frontal recess, ethmoid sinus, and nasal polyp separately.ResultsThe expression of IL-5 was significantly elevated in all sinonasal regions tested in the ECRS group, but absent in non-ECRS patients. Furthermore, the ECRS patients showed significantly increased levels of IL-5 in the frontal recess mucosa compared with ethmoid sinus mucosa. IL-6 was also significantly increased in the frontal recess mucosa compared with ethmoid sinus mucosa and nasal polyps in these patients. There were no significant differences in the levels of TGF-β or iNOS between the ECRS and non-ECRS groups in any sinonasal region tested.ConclusionsThis study is the first to characterize the cytokine milieu in the frontal recess of ECRS patients. We should keep these cytokine profiles in mind when we treat ECRS patients with frontal sinusitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

Kubota

Takeno

Taruya

et al. 2017

Journal of Otolaryngology - Head & Neck Surgery

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“…Chronic rhinosinusitis with nasal polyps patients have higher mucosal IL-5 protein levels compared with chronic rhinosinusitis without nasal polyps patients. 12 Moreover, in chronic rhinosinusitis with nasal polyps patients, IL-5 protein levels are reported to be higher in allergic nasal polyps compared with non-allergic nasal polyps. 13 The present study found a significant decrease in blood eosinophils in eosinophilic chronic rhinosinusitis patients after surgery, along with a reduction in serum IL-5 level.…”

Section: Discussionmentioning

confidence: 99%

Reduction of blood eosinophil counts in eosinophilic chronic rhinosinusitis after surgery

et al. 2016

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Objective: This study aimed to predict eosinophilic chronic rhinosinusitis prognosis by investigating changes in the blood eosinophil count and other disease biomarkers after surgery.Methods: Blood eosinophil numbers and serum interleukin-5 levels were measured in 22 eosinophilic chronic rhinosinusitis patients before and after functional endoscopic sinus surgery, and compared with equivalent measures in non-eosinophilic chronic rhinosinusitis patients and chronic rhinosinusitis without polyps patients. Differences between well-controlled eosinophilic chronic rhinosinusitis patients and those who experienced recurrence were also assessed.Results: Blood eosinophil numbers and serum interleukin-5 level decreased after surgery in eosinophilic chronic rhinosinusitis patients. In this patient group, blood eosinophil counts before surgery were significantly higher in patients who experienced recurrence (825.7 ± 26.1 vs 443.9 ± 76.6 cells/μl, p < 0.05), and decreased significantly after surgery (825.7 ± 26.1 vs 76.7 ± 25.8 cells/μl, p < 0.05).Conclusion: Blood eosinophil numbers may reflect disease severity in eosinophilic chronic rhinosinusitis patients and their prognosis after surgery.

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“…Non-eosinophilic inflammation is common in Chinese CRSwNP patients (28). The difference in endotypes is not associated with only racial differences; in a previous study, the cytokine profiles in Japanese patients with CRSwNP were found to be similar to those of European patients with CRS (29).…”

mentioning

confidence: 99%

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

Cheng

Wang

2016

Experimental and Therapeutic Medicine

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Abstract. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA. The results indicated that 15 (22.1%) patients had systemic allergies. On the basis of the ECP/MPO ratio, the patients were divided into an eosinophilic CRSwNP group (n=18) and a non-eosinophilic CRSwNP group (n=56). The total ECP/MPO ratio was 0.572, with a notable bias toward neutrophilic inflammation. The supernatant ECP and MPO levels were elevated in the CRSwNP group compared with the control group, but no significant difference in the serum total IgE and ECP levels were observed between the CRSwNP and control groups. In addition, the non-eosinophilic and eosinophilic CRSwNP groups showed significant elevations in supernatant total IgE, SEA and SEB levels compared with the control group. Thus, it may be concluded that allergy is a common pathogenesis of CRSwNP, and neutrophilic inflammation is present in most Chinese CRSwNP patients. Additionally, local indicators reflect the inflammatory status more accurately than do serum indicators. SEs may act as an infection factor rather than as a superantigen in Chinese non-eosinophilic CRSwNP patients. Thus, long-term antibiotic therapy may be an option for Chinese non-eosinophilic CRSwNP patients.

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Cytokine Profiles in Japanese Patients with Chronic Rhinosinusitis

Abstract: This study is thought to be the first one that showed the cytokine profiles in Japanese CRSs/wNP similar to those of European CRS. Based on mediator profiles, we suggest that CRSsNP and CRSwNP are distinct disease entities within the group of chronic sinus diseases.

Cited by 45 publications

References 26 publications

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients

Reduction of blood eosinophil counts in eosinophilic chronic rhinosinusitis after surgery

Different roles of Staphylococcus aureus enterotoxin in different subtypes of nasal polyps

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