2022
DOI: 10.3389/fimmu.2022.910428
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Cytokine Receptor-Like Factor 3 (CRLF3) Contributes to Early Zebrafish Hematopoiesis

Abstract: Cytokine receptor-like factor 3 (CRLF3) is an ancient protein conserved across metazoans that contains an archetypal cytokine receptor homology domain (CHD). This domain is found in cytokine receptors present in bilateria, including higher vertebrates, that play key roles in a variety of developmental and homeostatic processes, particularly relating to blood and immune cells. However, understanding of CRLF3 itself remains very limited. This study aimed to investigate this evolutionarily significant protein by … Show more

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Cited by 5 publications
(4 citation statements)
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“…Apart from this, studies on PC12 cells and iPSC-derived cerebral organoids indicated that CRLF3 regulates the development and differentiation of neurons ( Wegscheid et al, 2021 ). However, concrete functions of CRLF3 remained unknown until its regulatory role in vertebrate hematopoiesis and particularly in mammalian thrombopoiesis were recently reported ( Bennett et al, 2022 ; Taznin et al, 2022 ), though without discovering the identity of its ligand. Insect CRLF3 initiates anti-apoptotic neuroprotective mechanisms upon activation with both human Epo and EV-3 ( Hahn et al, 2017 , 2019 ).…”
Section: Discussionmentioning
confidence: 99%
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“…Apart from this, studies on PC12 cells and iPSC-derived cerebral organoids indicated that CRLF3 regulates the development and differentiation of neurons ( Wegscheid et al, 2021 ). However, concrete functions of CRLF3 remained unknown until its regulatory role in vertebrate hematopoiesis and particularly in mammalian thrombopoiesis were recently reported ( Bennett et al, 2022 ; Taznin et al, 2022 ), though without discovering the identity of its ligand. Insect CRLF3 initiates anti-apoptotic neuroprotective mechanisms upon activation with both human Epo and EV-3 ( Hahn et al, 2017 , 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…Their receptors (EpoR, TpoR, and GCSFR) belong to the class I family of cytokine type I receptors that possess the extracellular cytokine receptor homology domain and an WSXWS motif ( Boulay et al, 2003 ; Liongue and Ward, 2007 ; Hahn et al, 2019 ). Another member of this hematopoietic cytokine receptor family is the orphan cytokine receptor-like factor 3 (CRLF3) which was recently implicated in zebrafish hematopoiesis ( Taznin et al, 2022 ) and mammalian thrombopoiesis ( Bennett et al, 2022 ). Human CRLF3 contains the characteristic cytokine receptor motif (WSXWS), a single-pass transmembrane region and a Janus kinase docking site and is expressed in various tissues including the nervous system ( Boulay et al, 2003 ; Hahn et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
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