Cytokine regulation during the formation of the fetal–maternal interface: Focus on cell–cell adhesion and remodelling of the extra-cellular matrix

McEwan, Miranda; Lins, Roger J.; Munro, Sheryl; Vincent, Zoë; Ponnampalam, Anna P.; Mitchell, Murray D.

doi:10.1016/j.cytogfr.2009.05.004

Cited by 56 publications

(40 citation statements)

References 139 publications

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“…integrin alpha(IIb) beta (3)] facilitate the anchoring of the trophoblast to fibrin. 3 While integrin alpha(5) beta (1) improves the attachment to fibronectin of maternal origin, other integrins, such as integrin alpha(4) beta (4), are downregulated during the implantation process. 4 However, integrin expression is also present on endometrial cells, particularly integrin alpha(v) beta(3) and alpha(4) beta(1).…”

Section: Extracellular Matrix (Ecm)mentioning

confidence: 99%

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REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

Fitzgerald

Germeyer

Huppertz

et al. 2010

American J Rep Immunol

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Citation Fitzgerald JS, Germeyer A, Huppertz B, Jeschke U, Knöfler M, Moser G, Scholz C, Sonderegger S, Toth B, Markert UR. Governing the invasive trophoblast: current aspects on intra‐ and extracellular regulation. Am J Reprod Immunol 2010This review summarizes several aspects especially of regulating factors governing trophoblast invasion. Those include the composition of the extracellular matrix containing a variety of matrix metalloproeinases and their inhibitors, but also intracellular signals. Furthermore, a newly described trophoblast subtype, the endoglandular trophoblast, is presented. Its presence may provide a possible mechanism for opening and connecting uterine glands into the intervillous space. Amongst others, two intracellular signalling pathways are crucial for regulation of trophoblast functions and development: Wnt‐ and signal transducer and activator of transcription (STAT)3 signalling. Wnt signalling promotes implantation, placentation and trophoblast differentiation. Several Wnt‐dependent cascades and regulatory mechanisms display different functions in trophoblast cells. The STAT3 signalling system is fundamental for induction and regulation of invasiveness in physiological trophoblastic cells, but also in tumours. The role of galectins (Gal) in trophoblast regulation and placenta development comes increasingly into focus. The Gal‐ 1–4, 7–10 and 12–14 have been detected in humans. Detailed information is only available for Gal‐1, ‐2, ‐3, ‐4, ‐9 and ‐12 in endometrium and decidua. Gal‐1, ‐3 and ‐13 (‐14) have been detected and studied in trophoblast cells.

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Section: Extracellular Matrix (Ecm)mentioning

confidence: 99%

“…1 During the implantation process, trophoblast cells express mediators facilitating attachment and degradation of the ECM to be able to invade the endometrium and reach the maternal blood supply. 2 Along with other wellknown mediators such as hormones, growth factors and cytokines, several integrins [e.g.…”

Section: Extracellular Matrix (Ecm)mentioning

confidence: 99%

REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

Fitzgerald

Germeyer

Huppertz

et al. 2010

American J Rep Immunol

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“…E-cadherin was abundantly expressed in anestrus and in the proliferative stages of the bitch estrous cycle (proestrus and estrus), but its immunolabeling decreased during progesterone dominance, in particular in full diestrus, when progesterone levels are high. A similar down-regulation of E-cadherin expression during the progesterone phase of the cycle was reported in ewes [13] and in humans [37,45]. However, a small increase in E-cadherin mRNA was observed following exogenous progesterone administration to ovariectomized bitches [24].…”

Section: Discussionmentioning

confidence: 73%

“…Moreover, it has been proposed that E-cadherin/catenin complexes may play a role in initial attachment of the embryo during implantation [45], besides the maintenance of the endometrial histoarchitecture [37].…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium

et al. 2016

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Putative changes in E-cadherin and β-catenin during implantation in dogs are of interest to study, as they are both relevant for epithelial integrity. E-cadherin and β-catenin were immunolocalised in the canine cyclic and early pregnant endometrium, using monoclonal antibodies. Both molecules were detected in all types of endometrial epithelia (surface, superficial glandular and deep glandular epithelia) at all stages of the estrous cycle and in early placental structures. E-cadherin depicted a gradient of immunoreaction, intensity apparently being lowest in the surface epithelium to progressively increase towards the deepness of the endometrial glands, regardless of the stage of estrous cycle. The overall immunostaining was, however, weaker at diestrus. In pregnant samples trophoblast immunolabeling was stronger than in the endometrial surface epithelium; in the latter, the cytoplasmic pattern predominated over the membranous, as was also seen in the giant decidual cells in the labyrinth. In the early placenta, only trophoblast cells and lacunae retained membrane signals. β-catenin membrane labeling appeared relatively constant through the cycle, although a tendency towards a decrease in intensity was detected at the secretory stages. In addition, a dislocation of the immunoreaction to the cytoplasm was observed in both the surface and the glandular epithelia in particular stages of the cycle. In early pregnancy, a loss of the membranous pattern was observed in the surface epithelium and labyrinth, but neither on trophoblast nor in lacunae. The results showed the existence of a softening of adherens junctional complex in progestagen-dominated stages favoring embryo-maternal interactions and endometrial invasion during implantation.

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“…As citocinas IL1 e IL6 regulam a implantação e permitem a invasão dos trofoblastos, regulada pela metaloprotease colagenase tipo IV (Mcewan et al, 2009). A IL6 é uma citocina produzida por diversos tipos celulares, e tem função pró-inflamatória, mas também apresenta propriedades anti-inflamatórias.…”

Section: Marcadores Do Processo Inflamatóriounclassified

Avaliação da taxa de metilação do DNA em região promotora e de vitaminas e citocinas em mulheres com história de abortos recorrentes

Monteiro¹

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Cytokine regulation during the formation of the fetal–maternal interface: Focus on cell–cell adhesion and remodelling of the extra-cellular matrix

Cited by 56 publications

References 139 publications

REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium

Avaliação da taxa de metilação do DNA em região promotora e de vitaminas e citocinas em mulheres com história de abortos recorrentes

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