Cytokine response over the course of COVID-19 infection in pregnant women

Rosen, Daniel B.; Murphy, Elisabeth A.; Gejman, Ron S.; Capili, Allyson; Friedlander, Rachel L.; Rand, Sophie; Cagino, Kristen; Glynn, Shannon; Matthews, Kathy C.; Kubiak, Jeff M.; Yee, Jim; Prabhu, Malavika; Riley, Laura E.; Yang, Yunyun

doi:10.1016/j.cyto.2022.155894

Cited by 11 publications

(12 citation statements)

References 54 publications

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“…IL-18 is known as a pro-inflammatory cytokine involved in host defence against infections and regulating innate and acquired immune responses (Ihim et al, 2022). Our results are in agreement with other studies showing correlations of IL-18 serum levels with other markers of inflammation and disease severity (Rosen et al, 2022; Satis et al, 2021; Trifonova et al, 2023).…”

Section: Discussionsupporting

confidence: 94%

“…HGF produced by stromal and mesenchymal cells regulates epithelial cell proliferation, motility, morphogenesis, and angiogenesis (Gupta et al, 2022). HGF is a pleiotropic cytokine with anti-inflammatory properties that plays a key role in lung tissue repair and can modulate the adaptive immune response (Perreau et al, 2021;Sanchez-de Prada et al, 2022). Increased HGF production induced by lung injury promotes tissue repair (Gupta et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

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Plasma of COVID-19 patients does not alter electrical resistance of human endothelial blood-brain barrierin vitro

Pociūtė,

Kriaučiūnaitė,

Kaušylė

et al. 2023

Preprint

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The pandemic of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) instigated the most serious global health crisis. Clinical presentation of COVID-19 frequently includes severe neurological and neuropsychiatric symptoms. However, it is presently unknown whether and to which extent pathological impairment of blood-brain barrier (BBB) contributes to the development of neuropathology during COVID-19 progression. In the present study we used human induced pluripotent stem cells-derived brain endothelial cells (iBECs) to study the effects of blood plasma derived from COVID-19 patients on the BBB integrity in vitro. We also performed a comprehensive analysis of the cytokine and chemokine profiles in the plasma of COVID-19 patients, healthy and recovered individuals. We found significantly increased levels of interferon γ-induced protein 10 kDa (IP-10), hepatocyte growth factor (HGF), and interleukin-18 (IL-18) in the plasma of COVID-19 patients. However, blood plasma from COVID-19 patients did not affect transendothelial electrical resistance (TEER) in iBEC monolayers. Our results demonstrate that COVID-19-associated blood plasma inflammatory factors do not impair BBB integrity directly and suggest that pathological remodelling of BBB during COVID-19 may occur through indirect mechanisms.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Plasma of COVID-19 patients does not alter electrical resistance of human endothelial blood-brain barrierin vitro

Pociūtė,

Kriaučiūnaitė,

Kaušylė

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…These cytokines are known to be associated with the COVID cytokine storm ( Wang et al, 2021 ). In addition to IP-10, significantly higher IFN γ and IL-6 together with significantly lower IL-2, IL-10, and IL-17 levels have been observed in pregnant individuals with COVID-19 infection ( Rosen et al, 2022 ). Significantly higher IFN γ and IL-6 together have been reported to have positive correlations with disease severity in pregnant individuals with COVID-19.…”

Section: Resultsmentioning

confidence: 99%

Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls

Sabharwal

Demos

Snyder‐Cappione

et al. 2023

Journal of Reproductive Immunology

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“…A rapid cellular and humoral immune response is evoked during infection, increasing the possibility of suffering from adverse pregnancy outcomes. Patients infected with influenza ( Uchide et al, 2012 ), COVID-19 ( Rosen et al, 2022 ), Zika virus ( Rabelo et al, 2020 ), dengue virus ( Nunes et al, 2019 ), Chlamydia trachomatis of the reproductive tract ( Faris et al, 2019 ), HIV ( Akoto et al, 2021 ; Morrison et al, 2018 ), Plasmodium falciparum ( Chêne et al, 2014 ; Dobaño et al, 2018 ), and latent tuberculosis ( Indrati et al, 2022 ) had elevated levels of MIP1b, GROa, IL-8, RANTES, and IP10, but reduced levels of Eotaxin, MCP-1 ( Requena et al, 2015 ), associated with the inflammation in the placenta. The serum cytokine expression levels, which were associated with the type of infection, could provide predictive information about pathogen infection, mother-to-child-vertical transmission ( Kumar et al, 2012 ; Schnittman et al, 2021 ), immunity protection of host ( Amaral et al, 2020 ), and the risk of adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

Associations of circulation levels of cytokines with birthweight, preterm birth, spontaneous miscarriages, and stillbirth: A Mendelian randomization analysis

et al. 2023

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Background: The association between immune imbalances and adverse pregnancy outcomes has been extensive investigated by observational studies, but remain unclear. Thus, this study aimed to establish the causality of the circulation levels of cytokines on adverse pregnancy outcomes, such as offspring’s birthweight (BW), preterm birth (PTB), spontaneous miscarriage (SM), and stillbirth (SB).Methods: Two-sample Mendelian randomization (MR) analysis was employed to investigate potential causal relations between 41 cytokines and pregnancy outcomes on the basis of previously published GWAS datasets. Multivariable MR (MVMR) analysis was implemented to investigate the effect of the composition of cytokine networks on the pregnancy outcomes. Potential risk factors were further estimated to explore the potential mediators.Results: Genetic correlation analysis based on large GWAS data sources revealed that genetically predicted MIP1b (β = −0.027, S.E. = 0.010, p = 0.009) and MCSF (β = −0.024, S.E. = 0.011, p = 0.029) were associated with reduced offspring’s BW, MCP1 (OR: 0.90, 95% CI: 0.83–0.97, p = 0.007) was associated with reduced SM risk, SCF (β = −0.014, S.E. = 0.005, p = 0.012) associated with decreased number of SB in MVMR. The univariable MR showed that GROa (OR: 0.92, 95% CI: 0.87–0.97, p = 0.004) was associated with decreased PTB risk. Except for the MCSF-BW association, all above associations surpassed the Bonferroni corrected threshold. The MVMR results revealed that MIF, SDF1a, MIP1b, MCSF and IP10 composed cytokine networks, associated with offspring’s BW. Risk factors analysis indicated that the above causal associations might be mediated by smoking behaviors.Conclusion: These findings suggest the causal associations of several cytokines with adverse pregnancy outcomes, which were potentially mediated by smoking and obesity. Some of the results did not been corrected through multiple tests and larger samples verification is required in further studies.

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Cytokine response over the course of COVID-19 infection in pregnant women

Cited by 11 publications

References 54 publications

Plasma of COVID-19 patients does not alter electrical resistance of human endothelial blood-brain barrierin vitro

Plasma of COVID-19 patients does not alter electrical resistance of human endothelial blood-brain barrierin vitro

Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls

Associations of circulation levels of cytokines with birthweight, preterm birth, spontaneous miscarriages, and stillbirth: A Mendelian randomization analysis

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