Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome

Abstract

Hantaan virus (HTNV) infection of the human body causes a severe acute infectious disease known as hemorrhagic fever renal syndrome (HFRS). The aim of this study was to correlate patient cytokine profiles to HFRS severity. In this study, we discuss the clinical significance of evaluating HFRS treatment outcomes using cytokine information. The levels of 18 cytokines were quantitatively determined in three groups: 34 HTNV IgM+ cases, 63 HTNV IgM- negative cases, and 78 healthy volunteers. The level of 14 serum cytokines were higher in the patient group than that in the healthy control group. In the 34 HTNV IgM+ patient sera, a set of 27 cytokines was further assessed. The cytokines of TNF-β, IL-1ra, and IL-6 were detected at higher level in the IgM+ group than that in the IgM- group. The deterioration of HFRS was accompanied with multiple cytokines increased, such as IL-1ra, IL-12p70, IL-10, IP-10, IL-17, IL-2, and IL-6. Our data indicate that serum cytokine levels are associated with the progression of HFRS.

RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection

“…RIG-I, also known as DDX58, was reported to inhibit HTNV replication by facilitating HTNV-induced IFNβ production (Ma et al, 2017). HTNV infection enhanced the production of multiple cytokines, including interleukin (IL) 6 (Jiang et al, 2008;Yu et al, 2014;Guo et al, 2017). Besides, we previously demonstrated that myxovirus resistance 2 (MX2, also known as MXB) served as a potential inhibitor in HTNV infection (Li et al, 2019).…”

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus‐associated syndromes

“…Elevated IL‐6 levels in plasma have been associated with more severe HFRS . Elevated levels of IL‐6 and other cytokines such as IL‐8, IL‐10, TNF and IFN‐γ have also been detected in Dobrava virus‐infected and Hantaan virus‐infected HFRS patients and in HPS patients indicating that elevated levels of these cytokines are a general consequence of human hantavirus infection.…”

RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication

“…Hantaan orthohantavirus (HTNV) is the main causative agent of hemorrhagic fever with renal syndrome (HFRS) in humans, and is the most common etiology of hemorrhagic fevers in Asia. Human HTNV infection has a case-fatality rate as high as 10% [1,2]. HFRS is characterized by elevated levels of proinflammatory cytokines and endothelial cell activation that leads to vascular leakage, thus linking HTNV infection and HFRS with underlying innate immune activation and inflammatory disease.…”