Cytokine responses and myocardial injury in coronary artery bypass grafting

Wei, Minxin; Kuukasjärvi, Pekka; Laurikka, Jari; Kaukinen, S.; Iisalo, Pekka; Laine, Seppo; Laippala, Pékka; Metsänoja, Riina; Tarkka, Matti

doi:10.1080/00365510151097700

Cited by 38 publications

(4 citation statements)

References 4 publications

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“…As a result of these changes, animals treated with ND demonstrated increased blood pressure that reached hypertensive levels. These mechanisms are related to the ability of ND to produce a reduction of the anti-inflammatory cytokine (IL-10) and augmentation of the pro-inflammatory cytokines (IL-6 and TNF-a) causing cardiac remodeling and injury [ 63 , 64 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

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Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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“…15 Wei et al reported that plasma levels of IL-6, IL-8, and IL-10 at 5 minutes after crossclamp release correlated with myocardial injury, indicated by creatine kinase-MB levels at 6 hours. 7 We previously have found that elevated plasma levels of IL-6, IL-8, and IL-10 at 4 hours after reperfusion in lung transplantation correlated with progressive injury in the recipient allograft. 8 Thus, the early biomarker profile can identify patients more likely to progress to clinically apparent organ injury.…”

Section: Discussionmentioning

confidence: 90%

“…6 A correlation between the magnitude of cytokine response and severity of myocardial injury has been demonstrated. 7 In lung transplant patients, it has been shown that the magnitude of the early inflammatory response is associated with the severity of lung injury following transplantation. 8 Multiplex cytokine assays now allow measurement of 22 biomarkers simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Early Blood Biomarkers Predict Organ Injury and Resource Utilization Following Complex Cardiac Surgery

Kim

Arnaoutakis

Martin

et al. 2011

Journal of Surgical Research

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Background Patients undergoing complex cardiac surgery (thoracic aorta and valve) are at risk for organ failure and increased resource utilization. Neutrophil gelatinase-associated lipocalin (NGAL) has been found to be an early biomarker for renal injury. Multiplex cytokine immunoassays allow the evaluation of the early inflammatory response. We examined the relationship between early biomarker appearance (NGAL and multiplex cytokines) and organ injury and resource utilization. Materials and Methods NGAL and multiplex cytokine immunoassays were performed at baseline, 1, 6, and 24 hours following surgery on 38 patients undergoing thoracic aorta and valve operations. The mean age was 65 yrs with 26 males and 12 females. Acute kidney injury (AKIN definition), pulmonary failure (>24 hrs intubation), and intensive care unit and hospital stays were examined. Results One hour following complex cardiac surgery, the quartile of patients with the greatest IL-6 response had higher serum NGAL levels compared to the lowest quartile (347 vs. 145 ng/mL, p=0.002), and 70% of these patients progressed to clinical kidney injury. Six hours following surgery, the quartile of patients with the greatest IL-10 response had higher serum NGAL compared to the lowest quartile (271 vs. 160, p=0.04), more pulmonary failure (60% vs 10%, p=0.01), and longer ICU and hospital stays (p=0.001). Conclusions Patients with early elevated biomarkers of inflammation exhibited higher NGAL, more pulmonary failure, and greater resource utilization. Earlier identification of patients at risk for organ injury may allow for earlier intervention and reduce resource utilization.

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“…It is known that systemic inflammatory response plays a major role in perioperative complications. Interleukin (IL)-1b, IL-6, IL-8, and tumor necrosis factor-α (TNF-α) are produced in the acute phase of the inflammatory response, and high-sensitivity C-reactive protein (hs-CRP) has been shown to correlate with multi-organ failure [8,9,10]. We aimed to investigate the changes in renal function after on- and off-pump CABG and their association with hs-CRP and TNF-α for the first time.…”

Section: Introductionmentioning

confidence: 99%

On- versus Off-Pump Coronary Artery Bypass Grafting: No Difference in Early Postoperative Kidney Function Based on TNF-α or C-Reactive Protein

Nezami

Djavadzadegan²,

Tabatabaie-Adl³

et al. 2012

Cardiorenal Med

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Background/Aims: There are controversial data about renal function following off-pump coronary artery bypass grafting (CABG). The present study aimed to evaluate renal function changes 24 h after on- and off-pump CABG, as well as renal function correlated with high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α). Methods: Ninety patients with coronary artery disease referred to our center for CABG from July 2006 to November 2007 were enrolled in the study. Patients were equally and randomly divided in two groups, on- and off-pump. Serum levels of creatinine (Cr), blood urea nitrogen, creatinine clearance (CrCl), hs-CRP, and TNF-α were determined immediately before and 24 h after surgery. Results: Cr and CrCl changes after surgery were not significantly different between the two groups; however, blood urea nitrogen levels after surgery were significantly higher in the on-pump group (p = 0.035). No statistically significant difference was noted between the two groups in terms of changes in levels of hs-CRP and TNF-α (p = 0.350 and 0.805, respectively). The changes in CrCl levels had no significant correlation with hs-CRP and TNF-α. Conclusions: The early Cr and CrCl levels after surgery are not significantly different in on- and off-pump groups. The early renal function after on- or off-pump CABG is not correlated with the levels of inflammatory markers including hs-CRP and TNF-α.

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Cytokine responses and myocardial injury in coronary artery bypass grafting

Cited by 38 publications

References 4 publications

Nandrolone Decanoate: Use, Abuse and Side Effects

Nandrolone Decanoate: Use, Abuse and Side Effects

Early Blood Biomarkers Predict Organ Injury and Resource Utilization Following Complex Cardiac Surgery

On- versus Off-Pump Coronary Artery Bypass Grafting: No Difference in Early Postoperative Kidney Function Based on TNF-α or C-Reactive Protein

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