Cytokines and cecal microbiome modulations conferred by a dual vaccine in Salmonella-infected layers

Jan, Tong-Rong; Lin, Chen-Si; Wang, Shengyao; Yang, Wen‐Hsien

doi:10.1016/j.psj.2022.102373

Cited by 2 publications

(3 citation statements)

References 54 publications

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“…Additionally, the Firmicutes phylum was enriched while the abundance of the Lactobacillus genus was not altered when comparing recombinant protein-vaccinated chicks to those of the PBS-vaccinated control [85]. Similar results were observed when candidate and commercial non-typhoidal Salmonella vaccines were applied to broiler [86,87] and egg-type chickens [68,88]. Park et al [86] observed that various candidate Salmonella vaccines did not affect critical populations in broiler cecal microbiota, including genera such as Ruminococcus (short-chain fatty acid generation), Faecalibacterium (secretion of anti-inflammatory metabolites [89]), and Lactobacillus (lactic acid secretion).…”

Section: Vaccine Administration and Its Influence On Gut Microbiome S...supporting

confidence: 65%

“…Jan et al [88] also evaluated the ceca microbiota status in SPF chicks and commercial egg-type pullets following vaccination with a commercial Salmonella vaccine and a live Salmonella challenge. When compared to non-vaccinated control groups, the cecal microbiota composition of 30-day-old vaccinated, non-challenged SPF chicks was dominated by Faecalibacterium prausnitzii, Blautia hominis, and Subdoligranulum variabile species while the cecal microbiota composition of 27-week-old vaccinated, non-challenged commercial pullets were dominated by Subdoligranulum variabile, Negativibacillus massiliensis, and Mediterraneibacter glycyrrhizinilyticus [88]. Previously, genera like Faecalibacterium and Subdoligranulum were detected in the cecal pouch contents of broiler chickens [92], and their contribution to the human microbiota is considered beneficial [93,94].…”

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

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Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Beck,

Zhao,

Erf

2024

Applied Sciences

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At the turn of the 21st century, the importance of maintaining a balanced microbiome was brought to the forefront of the microbiology, immunology, and physiology research fields. Exploring the complex interactions between vaccine administration, mucosal microbiome, oral tolerance, and enteric inflammation in health and disease is challenging since environmental factors (such as diet and sanitation) have major influences on gut microbiota composition. High enteric pathogen load has been shown to contribute to dampened cell-mediated and humoral immune responses to vaccines in human case studies, either through elevated enteric inflammation or increased tolerance to environmental microbes. Although antibiotic and probiotic interventions have been evaluated in human health as well as research animal models, effective measures to mediate vaccine hyporesponsiveness are still ill-defined. Research in this field is becoming increasingly important for managing flock health in commercial poultry production, especially as antibiotic-free production is more prevalent and vaccination programs remain extensive during the first weeks of a bird’s life. By understanding the cellular interactions between commensal microbiota, vaccine antigens, and the host immune system (particularly in avian models), advancements in bacterial and viral vaccine immunogenicity could lead to improved flock health in meat-type and egg-type chickens in the future.

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Section: Vaccine Administration and Its Influence On Gut Microbiome S...supporting

confidence: 65%

Section: Vaccine Administration and Its Influence On Gut Microbiome S...mentioning

confidence: 99%

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Beck,

Zhao,

Erf

2024

Applied Sciences

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“…enteritidis and S . Typhimurium serovars) vaccine in specific pathogen-free layer chickens (< 16 days old) did not significantly affect the alpha diversity of the caecal microbiota ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

A live attenuated Salmonella Typhimurium vaccine dose and diluent have minimal effects on the caecal microbiota of layer chickens

Khan,

McWhorter,

Andrews

et al. 2024

Front. Vet. Sci.

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Among the Salmonella reduction strategies in poultry production, one option is to use a Salmonella vaccine. The aim of vaccinating layer flocks is to reduce the shedding of wild-type Salmonella in the poultry environment, thereby reducing the contamination of poultry products (eggs and meat). Nutritive diluent and a higher dose of vaccine may enhance its colonization potential in the gut of chickens. In this study, a commercially available live attenuated vaccine (Vaxsafe® ST) was reconstituted in different media and delivered orally to day-old chicks at three different doses (107, 108, and 109 CFU/chick). Gut colonization of the vaccine strain and the effects of vaccination on gut microbiota were assessed in commercial-layer chickens. The vaccine diluent and dosage minimally affected microbiota alpha diversity. Microbiota beta diversity was significantly different (P < 0.05) based on the vaccine diluent and dose, which indicated that the vaccinated and unvaccinated chickens had different gut microbial communities. Differences were noted in the abundance of several genera, including Blautia, Colidextribacter, Dickeya, Enterococcus, Lactobacillus, Pediococcus, and Sellimonas. The abundance of Colidextribacter was significantly lower in chickens that received vaccine reconstituted in Marek's and water diluents, while Lactobacillus abundance was significantly lower in the water group. The highest vaccine dose (109 CFU/chick) did not significantly alter (P > 0.05) the abundance of microbial genera. Chicken age affected the microbiota composition more significantly than the vaccine dose and diluent. The abundance of Lactobacillus, Blautia, Caproiciproducens, Pediococcus, and Colidextribacter was significantly higher on day 14 compared with day 7 post-vaccination. The Salmonella Typhimurium vaccine load in the caeca was not significantly affected by diluent and vaccine dose; however, it was significantly lower (P < 0.0001) on day 14 compared with day 7 post-vaccination. Overall, the S. Typhimurium vaccine minimally affected the gut microbiota structure of layer chicks, whereas changes in microbiota were more significant with chicken age.

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Cytokines and cecal microbiome modulations conferred by a dual vaccine in Salmonella-infected layers

Cited by 2 publications

References 54 publications

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

Vaccine Immunogenicity versus Gastrointestinal Microbiome Status: Implications for Poultry Production

A live attenuated Salmonella Typhimurium vaccine dose and diluent have minimal effects on the caecal microbiota of layer chickens

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