Cytokines and pathological sleep

Kapsimalis, Fotis; Basta, Maria; Varouchakis, Georgios; Gourgoulianis, Konstantinos; Vgontzas, Alexandros N.; Kryger, Meir H.

doi:10.1016/j.sleep.2007.08.019

Cited by 135 publications

(95 citation statements)

References 105 publications

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“…T H 2 cells therefore produce cytokines such as interleukins (IL) 4, 6, and 10. [17][18][19] Many other types of cells, including neurons in the brain and the periphery, as well as lymphoid tissue, have surface receptors for cytokines. The activity of one cytokine may overlap with the activity of another cytokine, including the synthesis and secretion of other cytokines.…”

Section: Cytokines and Sleepmentioning

confidence: 99%

“…In addition, cytokines are characterized by rapid utilization and degradation, quick binding to cellular receptors, and the effect of natural inhibitors. 18 Many cytokines are associated with sleep in animals and humans, including ILs 1, 2, 4, 6, 8, 10, 13, and 18; IFNs α, β, and γ; transforming growth factor; and TNF. 19,20 Table 2 is a summary of the effect of these cytokines on sleep.…”

Section: Cytokines and Sleepmentioning

confidence: 99%

“…Neurons in the hippocampus, hypothalamus, brain stem, and cortex have receptors for these cytokines. 18,20,[23][24][25] Administration of the cytokines causes an increase in NREM sleep in several species in lower doses and a decrease in higher doses. 20 If an animal is given a substance that suppresses or antagonizes the action of the cytokine, such as an antibody to or a soluble receptor for the cytokine, the level of NREM sleep is increased.…”

Section: Cytokines and Sleepmentioning

confidence: 99%

“…Based on Bollinger et al, 3 Nader et al, 12 and Hong et al and cortisol-inhibit sleep 17,18 and stimulate wakefulness, 17 whereas SWS inhibits activity of the HPA axis and the secretion of cortisol.…”

Section: Hpa Axis Sleep and Immune Functionmentioning

confidence: 99%

“…18 For example, sleep deprivation increased secretion of IL-6, 32 TNF-α, 32 IL-1, 33 and IL-2. 33 However, the direction of the response (whether the infection increases or decreases various immune functions) varies widely.…”

Section: Sleep Deprivation and Immune Functionmentioning

confidence: 99%

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Sleep and Immune Function

Ganz

2012

Critical Care Nurse

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the sleeper is unaware of the surroundings but can be easily aroused. Stage 3 is the first stage of deep or slow-wave sleep (SWS), which has both fast and slow brain waves. Stage 4, the second phase of SWS, consists mostly of slow waves. Stages 3 and 4 are considered the deepest stages of sleep, when waking the sleeper is difficult. SWS is considered a time of energy conservation and renewal. 10,11 It is an anabolic state in which physiological repair occurs.6 SWS has been widely studied in association with immune function. The next phase of sleep is rapid-eye movement (REM) sleep, in which dreaming occurs. 10The cycle of NREM sleep followed by REM sleep repeats 5 to 6 times per night for a period of 90 minutes per cycle. The relative amount of time spent in NREM and REM sleep changes during the night. NREM sleep takes up more time at the beginning of the night, and REM sleep occupies more time in the final sleep cycle. 11 The total amount and percentage of time spent in each cycle are species specific, but NREM sleep accounts for most of sleep in all animal species and in humans.2 These cycles are part of the daily sleep-wake cycle.

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Section: Cytokines and Sleepmentioning

confidence: 99%

Section: Cytokines and Sleepmentioning

confidence: 99%

Section: Cytokines and Sleepmentioning

confidence: 99%

Section: Hpa Axis Sleep and Immune Functionmentioning

confidence: 99%

Section: Sleep Deprivation and Immune Functionmentioning

confidence: 99%

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Sleep and Immune Function

Ganz

2012

Critical Care Nurse

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Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise

Zielinski

Gerashchenko

2015

Diet and Exercise in Cognitive Function and Neurological Diseases

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Genetic dysregulation in recurrent respiratory papillomatosis

et al. 2014

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Objectives/Hypothesis Recurrent respiratory papillomatosis (RRP) is a devastating disease, caused by infection of the upper aerodigestive tract with human papillomavirus types 6 and 11. There is no cure for RRP, and surgical removal is the mainstay of treatment. The purpose of this project was to compare genes of cell cycle, apoptosis, and inflammatory cytokines in laryngeal papilloma versus normal tissue for a better understanding of the molecular mechanisms of the disease to discover novel therapies. Study Design Basic science research study. Methods Papilloma tissue was obtained from patients requiring surgical debridement. For comparison, normal mucosa was obtained from the excised uvula of patients undergoing uvulopalatopharyngoplasty. Total RNA was extracted from both groups and then probed using customized reverse transcriptase real time polymerase chain reaction gene arrays. Results The custom arrays examine expression of 84 separate genes within the cell cycle, apoptosis, and inflammatory cytokine pathways. Our findings based on 11 papilloma samples run in comparison to normal mucosa shows that the MCL–1 gene of the apoptosis pathway is significantly downregulated. cytokine genes IL1-A, IL-8, IL-18, and IL-31 are also significantly dysregulated. Conclusions Genes of cell cycle and apoptosis are generally upregulated and downregulated, respectively, as expected in papilloma tissue, with MCL-1 achieving significance when compared to normal tissue. The finding of particular interest is that inflammatory cytokine genes were significantly downregulated, including IL1-A, IL-18, and IL-31. This finding may explain why patients infected with the virus are unable to mediate a T-cell immune clearance of their disease.

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Cytokines and pathological sleep

Cited by 135 publications

References 105 publications

Sleep and Immune Function

Sleep and Immune Function

Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise

Genetic dysregulation in recurrent respiratory papillomatosis

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