Cytokines and statin therapy in chronic obstructive pulmonary disease patients

Marević, Sanja; Petrik, József; Sanja, Popovic Grle; Čepelak, Ivana; Grgić, Ivo; Gorenec, Lana; Stjepanović, Gordana; Laškaj, Renata; Snjezana, Zidovec Lepej

doi:10.1080/00365513.2018.1514464

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…COPD patients receiving statins have a lower frequency of COPD exacerbations, hospitalizations, and antibiotic prescriptions than patients not receiving statins [15]. Significantly decreased concentrations of IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12p70, and TNF-α were found in COPD patients receiving statin therapy in comparison with COPD patients not receiving statin therapy (p < 0.05) [16]. It has been demonstrated that metformin and pioglitazone have pleiotropic effects and can be effective for COPD treatment in patients with type 2 diabetes, since they also have anticytokine action [17].…”

Section: Discussionmentioning

confidence: 93%

“…Currently, anticytokine therapy is regarded as a promising therapeutic approach for treatment of COPD. The efficacy of direct anticytokine medications, as well as multieffect preparations possessing anticytokine potential, is being actively studied [12][13][14][15][16][17][18][19][20][21][22][23]. Statins, HMG-CoA inhibitors, are widely known as preparations that have multiple effects, including anticytokine and anti-inflammatory potential [13,14].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Kirichenko

Sobenin

Markina

et al. 2020

Biology

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Chronic obstructive pulmonary disease (COPD) is a multifactorial disease, in which systemic inflammation plays a key role. This 6-month randomized double-blinded placebo-controlled study evaluates the possible effect of natural preparation Inflaminat on clinical symptoms of COPD, indicators of respiratory function, and exacerbation frequency in 60 patients with moderate severity of COPD. Inflaminat is a combination of natural ingredients black elder (Sambucus nigra L.) berries, violet (Viola tricolor L.) herb, and calendula (Calendula officinalis L.) flowers. The preparation has been previously demonstrated to possess anticytokine and anti-inflammatory effects in experimental studies. In present study, COPD dynamics were evaluated by means of BCSS (Breathlessness, Cough, and Sputum Scale) and spirometry tests. It was shown that 6-months Inflaminat administration led to significant decrease of BCSS points from 3.0 ± 0.6 to 1.9 ± 0.7, (p = 0.002) as well as significant increase of FEV1 from 66 ± 18% to 73 ± 17%, (p = 0.042); there were no beneficial dynamics in placebo group. Side effects associated with preparation administration were not identified. The results of the study suggest that Inflaminat may be employed in treatment of patients with moderate severity of COPD, since it has a positive effect on COPD symptoms according BCSS and indicators of respiratory function FEV1.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Kirichenko

Sobenin

Markina

et al. 2020

Biology

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“…Prior studies examining statins have has mixed results concerning benefits for COPD patients. Statin treatment is demonstrated to decrease inflammatory markers including CRP, Il‐6, and TNF‐alpha in COPD patients 22,23 . A recent meta‐analysis revealed increased FEV 1 and FEV 1 /FVC in addition to reduced rates of acute COPD exacerbations, suggesting that tangible clinical improvements occur with statin use 24 .…”

Section: Discussionmentioning

confidence: 99%

Suppression of cigarette smoke induced MMP1 expression by selective serotonin re‐uptake inhibitors

et al. 2021

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Globally, COPD remains a major cause of disability and death. In the United States alone, it is estimated that approximately 14 million people suffer from the disease. Given the high disease burden and requirement for chronic, long‐term medical care associated with COPD, it is essential that new disease modifying agents are developed to complement the symptomatic therapeutics currently available. In the present report, we have identified a potentially novel therapeutic agent through the use of a high throughput screen based on the knowledge that cigarette smoke induces the proteolytic enzyme MMP1 leading to destruction of the lung in COPD. A construct utilizing the cigarette responsive promoter element of MMP‐1 was conjugated to a luciferase reporter and utilized in an in vitro assay to screen the NIH Molecular Libraries Small Molecule Repository to identify putative targets that suppressed luciferase expression in response to cigarette smoke extract (CSE). Selective serotonin reuptake inhibitors potently inhibited luciferase expression and were further validated. SSRI treatment suppressed MMP‐1 production in small airway epithelial cells exposed to (CSE) in vitro as well as in smoke exposed rabbits. In addition, SSRI treatment inhibited inflammatory cytokine production while rescuing cigarette smoke induced downregulation in vivo of the anti‐inflammatory lipid transporter ABCA1, previously shown by our laboratory to be lung protective. Importantly, SSRI treatment prevented lung destruction in smoke exposed rabbits as measured by morphometry. These studies support further investigation into SSRIs as a novel therapeutic for COPD may be warranted.

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“…Moreover, it has been found to reduce adhesion molecules and some cytokines including IL-8, IL-6, and MCP-1 [44]. Due to the ability of the statin group to reduce inflammatory cytokine production, statin therapy has been applied as an alternative in some infectious diseases to prevent overuse-related antibiotic resistance, e.g., in intestinal Salmonella infections [45], Pseudomonas pneumonia [46], and chronic obstructive pulmonary disease (COPD) [47].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment

et al. 2020

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The role of interleukin-8 (IL-8), a pivotal chemokine in atherogenesis and coronary heart disease (CHD) development, is diverse and remains unclear. This cross-sectional study investigates the association of the IL-8 expression in hyperlipidemia (H) and CHD patients who have been treated with statin cholesterol-lowering drugs while undergoing coronary artery bypass grafting treatment. Fifty-five Thai volunteers including 13 normal (N), 24 H, and 18 CHD patients were enrolled for the investigation. All the CHD patients had been treated continuously with statin cholesterol-lowering medications since the disease was diagnosed and were undergoing coronary bypass grafting approximately one month later. Therefore, the CHD group was representative of a pathogenesis improvement in CHD. The IL8 mRNA expression was determined by real-time quantitative PCR in the peripheral blood mononuclear cells from heparinized blood. The plasma IL-8 levels were assessed by enzyme-linked immunosorbent assay. The result shows that the IL8 mRNA expression in the H group tended to increase; however, in the CHD group, there was a significant decrease (p=0.0111) compared to the N group. The IL8 mRNA expression and the plasma levels in the CHD group were significantly lower than those in the H group (p<0.05). A significant negative correlation between the IL8 mRNA (r = −0.499) or plasma IL-8 (r = −0.3875) expression and CHD progression was observed (p<0.05). In conclusion, the transcriptomic and the phenotypic IL-8 expression decreased significantly in the Thai CHD patients who had continuously received statin-group medications compared to the H and N group participants. Therefore, IL-8 should serve as a feasible marker and could be used to evaluate the therapeutic effects of statins and illustrate the pathology of CHD treatment.

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Cytokines and statin therapy in chronic obstructive pulmonary disease patients

Cited by 6 publications

References 31 publications

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Clinical Effectiveness of a Combination of Black Elder Berries, Violet Herb, and Calendula Flowers in Chronic Obstructive Pulmonary Disease: The Results of a Double-Blinded Placebo-Controlled Study

Suppression of cigarette smoke induced MMP1 expression by selective serotonin re‐uptake inhibitors

Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment

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