Cytokines and the Innate Immune Response at the Materno-Fetal Interface

AIM: To assess the level of expression of TLR2, TLR4, TLR7 genes in the placenta and fetal membranes during full-term physiological pregnancy, without signs of onset of labor. MATERIALS AND METHODS: The study was carried out at the premises of City Clinical Hospital No. 1 named after N.I. Pirogov (Samara), and included 15 pregnant women at 37-41 weeks of gestation without somatic pathology, exacerbation of chronic and acute inflammatory diseases, obstetric complications (placental insufficiency, preeclampsia). All patients were delivered by elective caesarean section due to fetal malposition. The level of expression of TLR2, TLR4, TLR7 genes was determined by reverse transcription and real-time PCR (RT-PCR) on the basis of the laboratory of NPO DNA-Technology using a set of reagents Proba NK. RESULTS: The data on the features of TLR2, TLR4, TLR7 expression in the placenta and membranes during full-term pregnancy were obtained. Direct correlations were found between the production of TLR2, TLR4, TLR7 of the fetal membranes and TLR2 of the placenta. The expression of placental TLR4 and TLR7 was not associated with the production of the TLRs. Significant differences were revealed in pregnant women with inflammatory and involutive-dystrophic changes in the placenta and the level of TLR4 expression. CONCLUSIONS: The expression of the Toll-like receptors (TLRs) in the tissues of the fetoplacental complex occurs uniformly during physiological pregnancy. There are positive correlations between the expression of TLR2, TLR4, TLR7 of the fetal membranes and TLR2 of the placenta, as well as its mass. The most significant indicator of the inflammatory process is the placental expression of TLR4.

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Cytokines and the Innate Immune Response at the Materno-Fetal Interface

Cited by 2 publications

References 217 publications

Peculiarities of local mRNA gene expression of pro- and anti-inflammatory cytokines in term pregnancy

Peculiarities of local mRNA gene expression of pro- and anti-inflammatory cytokines in term pregnancy

Gene expression of the congenital immunity in tissues of the placenta and fetal membranes in full-term pregnancy

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